Could ozone therapy be used to prevent COVID-19?

Yıl 2022, , 196 - 201, 30.05.2022

Kardelen Gencer-atalay Tulay Sahın

https://doi.org/10.5472/marumj.1121363

Öz

Objective: Ozone therapy has been shown to be beneficial in the prevention and treatment of various viral infections. This study
aimed to investigate the beneficial effect of ozone therapy against coronavirus disease 2019 (COVID-19).

Patients and Methods: A total of 71 individuals who completed at least ten sessions of ozone therapy applied by the method of major
autohemotherapy within the last six months were included and telephone call surveys were made.

Results: Two out of 71 participants were confirmed to have COVID-19. They both had mild symptoms and were discharged from the
hospital in five days. None of the participants with contact or travel history was infected.

Conclusion: Ozone therapy could be preventive against COVID-19. It could be considered as an alternative, easy-to-apply, safe, and
inexpensive method in the fight against COVID-19.

Anahtar Kelimeler

Coronavirus, Ozone, Preventive Medicine

Kaynakça

• [1] Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun 2020; 109:102433.
• [2] Stübinger J, Schneider L. Epidemiology of coronavirus COVID-19: Forecasting the future incidence in different countries. Healthcare (Basel) 2020; 15:8. doi:10.3390/ healthcare8020099.
• [3] Center for Systems Science and Engineering (CSSE). Coronavirus COVID-19 Global Cases. Available online: Https://coronavirus.jhu.edu/map.html (accessed on 01 April 2022).
• [4] Ahn DG, Shin HJ, Kim MH, et al. Current status of epidemiology, diagnosis, therapeutics, and vaccines for novel Coronavirus disease 2019 (COVID-19). J Microbiol Biotechnol 2020; 30:313-24.doi:10.4014/jmb.2003.03011.
• [5] Jirjees F, Saad AK, Al Hano Z, Hatahet T, Al Obaidi H, Dallal Bashi YH. COVID-19 Treatment Guidelines: Do they really reflect best medical practices to manage the pandemic? Infect Dis Rep 2021; 13:259-84.
• [6] Hernández A, Papadakos PJ, Torres A, et al. Two known therapies could be useful as adjuvant therapy in critical patients infected by COVID-19. Rev Esp Anestesiol Reanim 2020;67:245-57. doi:10.1016/j.redar.2020.03.004.
• [7] Rowen RJ. Ozone and oxidation therapies as a solution to the emerging crisis in infectious disease management: a review of current knowledge and experience. Med Gas Res 2019; 9:232-7.doi:10.4103/2045-9912.273962.
• [8] Rowen RJ, Robins H. A plausible “Penny” costing effective treatment for Corona virus – ozone therapy. J Infect Dis Epidemiol 2020; 6:113.doi.org/10.23937/2474-3658/1510113
• [9] Bocci V. Ozone: A new medical drug. 2nd edition. Netherlands: Springer, 2011. doi.org/10.1007/978-90-481-9234-2
• [10] Martínez-Sánchez G, Schwartz A, Donna V D. Potential cytoprotective activity of ozone therapy in SARS-CoV-2/ COVID-19. Antioxidants 2020; 9:389.
• [11] Noori-Zadeh A, Bakhtiyari S, Khooz R, Haghani K, Darabi S. Intra-articular ozone therapy efficiently attenuates pain in knee osteoarthritic subjects: A systematic review and metaanalysis. Complement Ther Med 2019; 42:240-7.doi:10.1016/j. ctim.2018.11.023.
• [12] Carmona L. [Ozone therapy in rheumatic diseases: a systematic review]. Rheumatol Clin 2006; 2:119-23.doi:10.1016/S1699- 258X(06)73032-7.
• [13] Moreno-Fernández A, Macías-García L, Valverde-Moreno R, et al. Autohemotherapy with ozone as a possible effective treatment for Fibromyalgia. Acta Reumatol Port 2019; 44:244- 9.
• [14] Wang YY, Jin YH, Ren XQ, et al. Updating the diagnostic criteria of COVID-19 “suspected case” and “confirmed case” is necessary. Military Med Res 2020; 7:17. doi.org/10.1186/ s40779.020.00245-9
• [15] Vishnevetsky A, Levy M. Rethinking high-risk groups in COVID-19. Mult Scler Relat Disord 2020; 42:102139. doi:10.1016/j.msard.2020.102139.
• [16] Wang B, Li R, Lu Z, Huang Y. Does comorbidity increase the risk of patients with COVID-19?: Evidence from metaanalysis. Aging 2020; 12:6049-57. doi:10.18632/aging.103000.
• [17] Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395:497-506.
• [18] Kunal S, Gupta K, Sharma SM, Pathak V, Mittal S, Tarke C. Cardiovascular system and COVID-19: perspectives from a developing country. Monaldi Arch Chest Dis 2020; 90. doi:10.4081/monaldi.2020.1305.
• [19] Muniyappa R, Gubbi S. COVID-19 pandemic, coronaviruses, and diabetes mellitus. Am J Physiol Endocrinol Metab 2020; 318:736-41.doi:10.1152/ajpendo.00124.2020.
• [20] Samuels JD. Obesity and severe COVID-19 disease: a strong association. Obesity (Silver Spring) 2020;28:1368. doi:10.1002/ oby.22866.
• [21] Diaz-Luis J, Menendez-Cepero S, Diaz-Luis A, Ascanio – Garcia Y. In vitro effect of ozone in phagocytic function of leucocytes in peripheral blood. J Ozone Ther 2015; 1.
• [22] Elvis AM, Ekta JS. Ozone therapy: A clinical review. J Nat Sci Biol Med 2011; 2:66-70. doi: 10.4103/0976-9668.82319.
• [23] Giovanni R, Marianno F, Luigi V. Oxygen-ozone immunoceutical therapy in COVID-19 outbreak. Ozone Ther 2020; 5:9014
• [24] Wang Z, Zhang A, Meng W, et al. Ozone protects the rat lung from ischemia-reperfusion injury by attenuating NLRP3- mediated inflammation, enhancing Nrf2 antioxidant activity and inhibiting apoptosis. Eur J Pharmacol 2018; 835:82-93. doi:10.1016/j.ejphar.2018.07.059.
• [25] Cespedes-Suarez J, Martin-Serrano Y, Carballosa-Peña M, Dager-Carballosa D. The immune response behavior in HIVAIDS patients treated with Ozone therapy for two years. J Ozone Ther 2018; 2:7.
• [26] Cespedes-Suarez J, Martin-Serrano Y, Carballosa- Peña M, Dager-Carballosa D. Response of patients with chronic hepatitis B in one year of treatment with major autohemotherapy. J Ozone Ther 2018; 2:9.
• [27] Zaky S, Kamel S, Hassan M, et al. Preliminary Results of Ozone Therapy as a Possible Treatment for Patients with Chronic Hepatitis C. Journal of alternative and complementary medicine 2011; 17:259-63.
• [28] Rowen R, Robins H, Carew K, Kamara M, Jalloh M. Rapid resolution of hemorrhagic fever (Ebola) in Sierra Leone with ozone therapy. Afr J Infect Dis 2015; 10:49.
• [29] Cattel F, Giordano S, Bertiond C, et al. Ozone therapy in COVID-19: A narrative review. Virus Res 2021; 291:198207.