Synthesis of some novel Carbazole derivatives and evaluation of their antimicrobial activity

Yıl 2011, Cilt: 15 Sayı: 3, 105 - 109, 07.03.2014

Zafer Kaplancıklı

Öz

Anahtar Kelimeler

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Bazı yeni karbazol türevlerinin sentezleri ve antimikrobiyal aktivitelerinin araştılılması

Öz

Karbazol ve türevleri, antimikrobiyal aktiviteleri nedeniyle medisinal kimyacıların ilgisini çeken azotlu heterosiklik bileşiklerdir. Bu amaçla yeni karbazol türevleri sentezlendi ve antimikrobiyal aktiviteleri araştırıldı. Başlangıç maddesi olarak 2-kloro-N-(9-etil-9H-karbazol-3-il)asetamid, 3-amino-9-etil-9H-karbazol ile kloroasetil klorürün reaksiyonuyla hazırlandı. 2-Kloro-N-(9-etil-9H-karbazol-3-il)asetamid ile merkapto-heterosikliklerin reaksiyonu ile sonuç bileşikleri elde edildi. Bileşiklerin kimyasal yapıları IR, 1H-NMR, FAB-MS spektroskopik verileri ve elemental analiz ile aydınlatıldı. Bileşiklerin antimikrobiyal aktiviteleri Candida albicans (iki suş), Candida glabrata, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa’a karşı araştırıldı

Anahtar Kelimeler

Karbazol, antimikrobiyal aktivite

Kaynakça

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