Yara İyileşmesi ve Oksidatif Stres

Yıl 2014, Cilt: 18 Sayı: 3, 153 - 158, 12.09.2014

Halil Aksoy , Özlem Bingöl Özakpınar

Öz

Aerobik hücrelerin normal metabolik yolaklarında bulunan

çeşitli enzimler ile travma, enfeksiyon, reperfüzyon ve

inflamasyon gibi çevresel faktörler reaktif oksijen türlerini

(ROT) oluşturur. Bu radikaller bir veya birden fazla

eşleşmemiş elektron içeren moleküller olup, yüksek kimyasal

aktivitelerinden dolayı hücresel makromoleküllerin hasarına

neden olurlar. Son yıllarda oksidatif stresin hem savunma

sisteminde hem de yara iyileşmesinde de rol aldığı birçok

çalışmada ortaya konmuştur. Diğer taraftan, yara

iyileşmesinde büyük bir role sahip olan ROT’un etki

mekanizmasıtam olarak aydılatıamamışı. Bu nedenle,

ROT’un oluşmu ve oluşn bu üülerin detoksifikasyonu

yara iyileşesinde büü öem kazanmaktadı. Bu da tedavi

içn yeni yötemlerin gelişesine öemli katkıar

sağayacaktı. Bu çlışada, yara iyileşesinde rolüolan

çştli antioksidan moleküler ile ROT’ un detoksifiye

enzimleri anlatıacaktı.

Anahtar Kelimeler: Antioksidan, oksidatif stres, reaktif

oksijen türleri, yara iyileşmesi

Anahtar Kelimeler

Antioksidan, oksidatif stres, reaktif oksijen türleri, yara iyileşmesi

Kaynakça

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