Elektroeğrilmiş Nanoliflerin İlaç Taşıyıcı Sistem Olarak ve Doku Mühendisliğinde Kullanımı

Year 2017, Volume: 21 Issue: 3, 425 - 435, 18.04.2017

Bürde Süheyla Sunar Canan Hasçiçek

https://doi.org/10.12991/marupj.306787

Abstract

Nanofibers which have a longer length than its diameter

are widely used in many areas i.e. drug delivery systems and

tissue engineering because of their convenient surface area to

volume ratio. Electrospinning is the most common method for

processing nanofibers. The nanofibers that are processed by

electrospinning are called electrospun nanofibers. During the

process, physicochemical properties of electrospun nanofibers

can be affected by different parameters including applied voltage,

solution flow rate, distance between capillary and collector,

polymer physicochemical properties. Drug release properties

of electrospun nanofibers are determined by diffusion and

polymer degradation. Additionally, nanofibers’ types i.e. matrix

types or reservoir types affect drug release properties. Since the

physical properties of nanofibers allow researchers to produce

an artificial extracellular matrix to mimic microenvironments

of tissues, they are used in tissue engineering for regeneration

and production of a new tissue or an organ. Biosimilar

nanofibers, therefore, can be obtained by modifying surfaces

of nanofibers. Findings of our study suggest that because of

their biosimilar character and providing intended drug release

profile, nanofibers have a promising potential in the future of

tissue engineering research.

Keywords

biosimilar, tissue engineering, electrospinning, drug delivery systems

Elektroeğrilmiş Nanoliflerin İlaç Taşıyıcı Sistem Olarak ve Doku Mühendisliğinde Kullanımı

Abstract

Uzunlukları çaplarına kıyasla oldukça fazla olan nanolifler,

sahip oldukları yüksek yüzey/hacim oranı ile ilaç taşıyıcı

sistemler ve doku mühendisliği de dahil olmak üzere birçok

alanda kullanım potansiyeline sahiptir. Farklı yöntemlerle

üretilme imkanı olan nanoliflerin en cazip üretim metodu

elektroeğirme yöntemidir. Bu yöntemle üretilen nanoliflerin

fizikokimyasal özellikleri; uygulanan voltaj, polimer çözeltisinin

akış hızı, kapiller ve kolektör arasındaki mesafe, polimerin

fizikokimyasal özellikleri ve kullanılan çözücü gibi birçok

parametreden etkilenmektedir. Elektroeğrilmiş nanoliflerin

etkin madde salım özellikleri, etkin maddenin difüzyonu ve

taşıyıcı polimerin degredasyonu ile belirlenmektedir. Ayrıca

nanoliflerin etkin madde salım özelliklerini lifin matriks veya

depo yapısında olması, yüzeyinde aktif bileşenlerin bulunması

etkilemektedir. Sahip olduğu fiziksel özellikler nedeniyle

nanolifler, hücrelerin fizyolojik çevresini taklit etmek amacıyla

yapay ekstraselüler matriksler geliştirilerek doku ve organların

rejenerasyonunu ya da üretimini hedefleyen doku mühendisliği

alanında kullanımı için oldukça elverişlidir. Bu amaçla

nanoliflerin yüzey özellikleri değiştirilerek biyobenzer yapılar

elde edilebilmektedir. Nanolifler, etkin maddenin hedeflenen

salım profilini sağlaması ve biyobenzer özellik kazanarak doku

mühendisliğinde kullanımına imkan vermesi ile gelecek vaat

eden sistemlerdir.

Keywords

Biyobenzer, doku mühendisliği, elektroeğirme, ilaç taşıyıcı sistem, nanolif

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