Nonobstruktif Azospermik Hastalarda Yapılan Mikrocerrahi Testiküler Sperm Ekstraksiyonu Sonuçları ve Bu Sonuçları Etkileyen Faktörlerin Değerlendirilmesi

Yıl 2017, Cilt: 1 Sayı: 3, 122 - 126, 15.12.2017

Murat Uçar , Taylan Oksay , Alper Özorak Sedat Soyupek Abdullah Armağan , Alim Koşar

https://doi.org/10.30565/medalanya.342563

Cited By: 1

Öz

Amaç: Kliniğimizde nonobstruktif azospermi (NOA) tanısıyla mikro-TESE (mikrocerrahi testiküler sperm ekstraksiyonu) uygulanan 71 hastanın sonuçlarını, hormonal özelliklerini ve  bu sonuçların Johnsen skorlarıyla ilişkisini incelemek.

Hastalar ve Yöntem: Kliniğimize 2010-2014 yılları arasında başvuran ve NOA tanısıyla mikro-TESE uygulanan 71 hastanın verilerini retrospektif olarak inceledik. Hastaların yaşı, infertilite süreleri, geçirdiği operasyonlar, ortalama testis volümleri, kan FSH (folikül stimülan hormon), LH (luteinizan hormon), total testosteron ve prolaktin düzeyleri, biyopsi alınan hastaların biyopsi sonuçları ve bunların mikro-TESE başarısı ile ilişkisi değerlendirildi.

Bulgular: Mikro-TESE uygulanan 71 hastanın 25’inde (%35,21) sperm bulunmuş, bunların 6 (%8,45) tanesinde gebelik gelişmiştir. Ortalama testis hacimleri sağ 14,3±3,80 (4-22) cc, sol 13,7±3,41 (4-20) cc olarak bulunmuştur. FSH ve LH değeri arttıkça sperm bulma olasılığı azalmıştır (p<0,05). Total testosteron ve prolaktin düzeyleri ile TESE'de sperm bulma arasında korelasyon saptanmamıştır (p>0,05).

Sonuç: Mikro-TESE’de sperm elde etme başarısı hasta yaşı, geçirilmiş testis operasyonu, testis volümü, hastanın hormonal profili ile değişebilmektedir. Sperm elde etme başarısı histoloji, kan FSH ve LH değerleri ile korele olup, hasta yaşı, infertilite süresi, kan total testosteron, prolaktin değerleri ve testis volümü ile ilişkisi net değildir

Anahtar Kelimeler

İnfertilite, Azospermi, MikroTESE

Microsurgical Testicular Sperm Extraction Results in Nonobstructive Azospermic Disease and Evaluation of the Factors Affecting These Results

Öz

Aim: To investigate the hormonal properties and results of 71 patients, who were diagnosed with nonobstructive azoospermia (NOA) and performed micro-TESE (microsurgical testicular sperm extraction) at  our clinic, and the relationship of these results and  Johnsen scores.

Patients and Method: We retrospectively reviewed the data of 71 patients who came to our clinic and were diagnosed with NOA and got performed micro-TESE between the years of  2010 and 2014. Variables such as age, the duration of infertility, operations underwent, mean testis volumes, blood FSH (follicle stimulated hormone), LH (luteinizing hormone), total testosterone and prolactin levels, results and their relations with sperm retrieval rates were examined.

Results: Sperm were found in 25 (35.21%) of 71 patients, who were performed micro-TESE, and 6 (8.45%) of them have developed pregnancy. Mean testis volumes were found 14.3 ± 3.80 (4-22) cc on the right and 13.7 ± 3,41 (4-20) cc on the left. As FSH and LH values increased, the probability of sperm retrieval rate was decreased (p <0.05). There was no correlation between total testosterone and prolactin levels with sperm retrieval in TESE (p> 0,05).

Conclusion: In micro-TESE, the success of sperm retrieval can be affected by patient age, having testis operation history, testis volume, patient's hormonal profile. Sperm retrieval success correlates with histology, blood FSH and LH values, if there is a relation sperm retrieval success and patient age, duration of infertility, blood total testosterone, prolactin levels and testis volume is unclear.

Anahtar Kelimeler

Infertility, Azospermia, Micro-TESE

Kaynakça

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