Effect of Prenatal Citalopram Exposure on Motor and Cognitive Functions of Rats

Yıl 2019, Cilt: 3 Sayı: 3, 213 - 219, 26.10.2019

Ayşenur Zaimoğlu Bahar Akyüz , S. Sırrı Bilge

https://doi.org/10.30565/medalanya.556757

Öz

Aim: Physicians mostly prescribe selective serotonin reuptake inhibitors in the treat-ment of depression in pregnancy. However, there is little information on teratogenic effects of selective serotonin reuptake inhibitors. This study aims to investigate the ef-fects of prenatal exposure to citalopram, one of the most prescribed antidepressants, on developmental characteristics, reflex and motor functions of rat pups.

Materials and Methods: 12-14 weeks old, pregnant Sprague-Dawley rats were used in the experiments. Rats were divided into 3 groups and separated into individual cag-es. When treatment groups received 5 and 20 mg/kg/d citalopram by orogastric ga-vage from gestational days 1 to 18, control group received the same amount of saline (2 ml/kg/d). After birth duration of gestation, number of live and dead pups and gross malformation are evaluated. Eye opening, pinna detachment, incisor eruption, the development of fur and weight gain were monitored as developmental parameters. Markers for reflex development were identified as righting reflex, negative geotaxis and grip response. Motor developments and cognitive functions were established with locomotor activity test, T-maze, holeboard, Y-maze and passive avoidance test.

Results: Developmental parameters, reflex, motor and cognitive development as-sessments of pups were not significantly different in treatment groups compared to control group. 

Conclusion: The results of the study show that prenatal exposure to citalopram has no effect on motor and cognitive functions of rat offspring.

Anahtar Kelimeler

Depression, selective serotonin re-uptake inhibitors, rat, citalopram, teratogenity

Prenatal Sitalopram Maruziyetinin Sıçanların Motor ve Kognitif Fonksiyonları Üzerine Etkisi

Öz

Amaç: Seçici serotonin geri alım inhibitörleri gebelikte depresyon tedavisinde sıklıkla reçete edilmektedirler. Ancak bu gruptaki ilaçların teratojenik etkileriyle alakalı literatürde yeterli bilgi yoktur. Bu çalışmanın amacı; sık reçete edilen antidepresanlardan biri olan sitaloprama prenatal dönemdeki maruziyetin, sıçan yavrularının motor ve kognitif fonksiyonları üzerine etkilerinin araştırılmasıdır. 

Materyal ve Metot: Deneylerde 12-14 haftalık gebe Sprague-Dawley sıçanlar kullanıldı. Sıçanlar üç gruba ayrıldı ve ayrı kafeslerde barındırıldılar. Tedavi gruplarına, 1 ila 18. günler arasında orogastrik gavaj ile 5 ve 20 mg/kg/gün sitalopram, kontrol grubuna ise aynı miktarda tuzlu su (2 ml/kg/gün) verildi. Doğumdan sonra gebelik süresi, canlı ve ölü yavru sayısı ve brüt malformasyon değerlendirildi. Gelişimsel parametre olarak göz açma, kulak kepçesinin ayrılması, kesici diş çıkması, tüylenme ve kilo alımı değerlendirildi. Righting refleks, negatif geotaksi ve grip response refleks gelişimini değerlendirmek için yapıldı. Motor gelişim ve kognitif fonksiyonların değerlendirilmesi için lokomotor aktivite testi, T-maze, holeboard, Y-maze, ve pasif sakınma testleri yapıldı. 

Bulgular: Gelişimsel parametreler, refleks, motor ve kognitif gelişim açısından tedavi grubundaki sıçanlar ile kontrol grubundaki sıçanlar arasında anlamlı bir farklılık meydana gelmedi. 

Sonuç: Bu çalışma ile sitaloprama maruziyetin yavrularda motor ve kognitif fonksiyonlar üzerinde değişikliğe sebep olmadığı gösterildi. 

Anahtar Kelimeler

Depresyon, seçici seratonin geri alım inhibitörleri, sıçan, sitalopram, teratojenite

Kaynakça

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