Effect of Subthalamic Nucleus Deep Brain Stimulation Treatment on Non-motor Symptoms and Sleep Quality in Parkinson’s Disease Patients

Yıl 2023, Cilt: 7 Sayı: 1, 59 - 65, 21.06.2023

Nazan Şimşek Erdem , Gokce Yagmur Gunes Gencer , Sehür Sibel Özkaynak , Tanju Uçar

https://doi.org/10.30565/medalanya.1221314

Cited By: 1

Öz

Aim: To evaluate the effect of subthalamic nucleus deep brain stimulation (STN-DBS) on non-motor symptoms (NMS), sleep quality, and excessive daytime sleepiness in patients with Parkinson’s Disease (PD).

Method: Sixteen PD patients, who had undergone bilateral STN-DBS surgery were enrolled. The patients were assessed at the baseline and 12 months after surgery using the Unified Parkinson's Disease Rating Scale (UPDRS), Parkinson's Disease Questionnaire (PDQ-39), Beck Depression Inventory-II (BDI), Hospital Anxiety and Depression Scale (HADS), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and Non-Motor Symptom Questionnaire (NMS-Quest).

Results: The mean age of the patients at the time of surgery was 53.5±3.6 years. There were significant improvements in the levodopa-equivalent daily dose, UPDRS-part-II, UPDRS-part-III, and UPDRS-part-IV at 12 months post-DBS surgery. The NMS-Quest total score at baseline was correlated with the disease duration of the patients (p=0.005 R:0.66). The PSQI score at baseline was significantly associated with a high total UPDRS and HADS score (p=0.03, p=0.004 respectively). There were no significant differences in terms of NMS-Quest total and subdomains thereof and PSQI total score and subdomains thereof, UPDRS-part I, BDI-II and HADS scores between baseline and 12 months post-DBS surgery (p>0.05 for all of them).

Conclusion: STN-DBS surgery did not change subjective sleep quality, excessive daytime sleepiness, and NMS although it improved motor symptoms, motor fluctuations, and the health-related quality of life

Anahtar Kelimeler

subthalamic nucleus deep brain stimulation (STN-DBS), sleep quality, non-motor symptoms, excessive daytime sleepiness

Parkinson Hastalarında Subtalamik Çekirdek Derin Beyin Stimülasyonu Tedavisinin Non-motor Semptomlara ve Uyku Kalitesine Etkisi

Öz

Amaç: Parkinson Hastalığı (PH) olan hastalarda subtalamik nukleus derin beyin stimülasyonunun (STN-DBS) non- motor semptomlar (NMS), uyku kalitesi ve gündüz aşırı uykululuk üzerine etkisini değerlendirmek.

Yöntem: Bilateral STN-DBS cerrahisi geçirmiş 16 PH hastası çalışmaya alındı. Hastalar ameliyat öncesi ve ameliyattan 12 ay sonra Birleşik Parkinson Hastalığı Derecelendirme Ölçeği (BPHDÖ), Parkinson Hastalığı Anketi (PDQ-39), Beck Depresyon Envanteri-II (BDI), Hastane Anksiyete ve Depresyon Ölçeği (HADS), Pittsburgh Uyku Kalitesi İndeksi (PSQI), Epworth Uykululuk Ölçeği (ESS) ve Non-motor Semptom Anketi (NMS-Quest) kullanılarak değerlendirildi.

Bulgular: Hastaların ameliyat anındaki ortalama yaşı 53,5±3,6 idi. DBS ameliyatından 12 ay sonra levodopa eşdeğeri günlük dozunda, BPHDÖ-bölüm-II, BPHDÖ-bölüm-III ve BPHDÖ-bölüm-IV'te anlamlı iyileşmeler oldu. Başlangıçtaki NMS-Quest toplam puanı, hastaların hastalık süresi ile koreleydi (p=0,005 R:0,66). Başlangıçtaki PSQI skoru, yüksek BPHDÖ toplam skor ve HADS skoru ile anlamlı şekilde ilişkiliydi (sırasıyla p=0.03, p=0.004). Başlangıçtaki ve DBS cerrahisinden 12 ay sonraki NMS-Quest toplam ve alt alanları, PSQI toplam puanı ve alt alanları, BPHDÖ-bölüm-I, BDI-II ve HADS puanları arasında anlamlı fark yoktu (p>0,05 tümü için ).

Sonuç: STN-DBS cerrahisi motor semptomları, motor dalgalanmaları ve sağlıkla ilişkili yaşam kalitesini iyileştirmesine rağmen gündüz aşırı uykululuk halini, subjektif uyku kalitesini ve NMS'yi değiştirmedi.

Anahtar Kelimeler

subtalamik nukleus derin beyin stimülasyonu (STN-DBS), uyku kalitesi, non- semptomlar, gündüz aşırı uykululuk hali

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