The effects of exercise on vascular responses in rats with type 1 diabetes

Yıl 2024, Cilt: 9 Sayı: 1, 247 - 253, 12.06.2024

Zihni Can , Cengiz Ünsal

Öz

Diabetes causes dysfunctions and damages in different tissues over time. It has been known that exercise has beneficial effects on the pathologies associated with diabetes. This study was aimed to evaluate the effects of moderate swimming exercise on vascular responses in rats with type 1 diabetes. The groups in the experiment were conducted as diabetes, diabetes exercise, exercise, and control. Streptozotocin (50 mg/kg) was intraperitoneally given to induce type 1 diabetes. The rats in group diabetes exercise and exercise were subjected to a swimming protocol was applied 5 days a week and 1 hour a day for 4 weeks after streptozotocin injection. The initial and final blood glucose levels and weekly body weights were measured. At the end of the study, in vitro thoracic aorta responses were recorded. A reduction in body weight of rats with type 1 diabetes was determined from week 1 to week 4 (p<0.001). Blood glucose levels were significantly (p<0.001) higher in both diabetic groups than those of controls and group exercise. The 4-week swimming exercise had no effect on blood glucose levels of diabetic rats. The responses of the thoracic aorta to norepinephrine and sodium nitroprusside were not different between groups. The control rats showed the highest relaxation response of the thoracic aorta to acetylcholine while this response gradually decreased in groups diabetes exercise, exercise, and diabetes. In conclusion, it was observed that 4-week moderate swimming exercise regimen corrected endothelium-dependent relaxation responses in rats with type 1 diabetes.

Anahtar Kelimeler

acetylcholine, aorta, exercise, phenylephrine, rat, type 1 diabetes

Etik Beyan

The study was approved by the Aydın Adnan Menderes University Animal Experiments Local Ethics Committee (approval number: 64583101/2014/142).

Proje Numarası

VTF-15021.

Teşekkür

This study was presented as an oral presentation at the 42nd National Physiology Congress of Turkish Physiological Sciences Association (Düzce University Congress Center 05-08 September 2016). The abstract of the presentation is published in the Congress Proceedings and ACTA Physiologica Volume 215, Issue S704. In addition, the serum samples obtained from the study were analyzed and presented (Oral Presentation) with the title “The Effect of Swimming Exercise on Lipid Profile and Oxidant-Antioxidant Status in Type I Diabetic Rats” in 10th The 10th International Conference in Physical Education, Sports and Physical Therapy (18-20 November 2016 Fırat University, Faculty of Sport Sciences, Elazig). This chapter was published in “F.Ü. Sağ. Bil. Tıp Derg. 2016; 30 (3): 119-123” as full text.

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