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D Vitamini Seviyesi Preeklampsinin Şiddetini Değiştirir mi? Tek Merkezli Vaka Kontrol Çalışması

Yıl 2022, Cilt: 4 Sayı: 3, 328 - 332, 22.09.2022
https://doi.org/10.37990/medr.1095867

Öz

Amaç: D vitamini eksikliği ile preeklampsinin şiddeti arasındaki ilişkiyi araştırmayı amaçladık.
Materyal Metot: Preeklampsi(PE), şiddetli preeklampsi, eklampsi ve HELLP sendromu (Hemoliz, Yüksek Karaciğer enzimleri, Düşük Trombosit) hastalarında D vitamini serum düzeylerini değerlendirmeyi amaçlayan bir vaka-kontrol çalışması gerçekleştirdik. 18-40 yaşları arasında spontan vajinal doğum veya sezaryen olan toplam 69 hasta çalışmaya dahil edildi.
Bulgular: Hstaların demografik verileri benzer olup şiddetli PE de yaş diğer gruplardan yüksek olarak bulundu. BMI değerlendirildiğinde şiddetli PE de hafif pe ye göre anlamlı olarak yüksek olup diğer gruplarla benzer bulundu. Tüm grupların d vit değeri ortalama 8,75±3,5 olup şiddetli PEi nin ortalaması 6,69±3 olup diğer gruplara göre anlamlı olarak düşük bulundu. Hafif PE de d vitamini seviyesi ortalama 10,99±2.91 olup tüm gruplardan yüksek olup.şiddetli PE ve HELLP sendromlu hastalara göre anlamlı olarak yüksek bulundu.
Sonuç: Gebelikte yeni başlayan hipertansif bozuklukların şiddeti ile D vitamini eksikliği derecesi arasında anlamlı bir ilişki olduğunu düşünmekteyiz. Bunları önlemek ve şiddetini azaltmak içim d vitamini seviyesinin kontrolü ve tedaviye eklenmesinin hastalık seyrini olumlu etkileyeceğini düşünmekteyiz.

Kaynakça

  • 1. Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J. Steroid Biochem. Mol. Biol.2014; 144:138-145. doi: 10.1016/j.jsbmb.2013.11.003
  • 2. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: An endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011; 96(7):1911-1930. doi: 10.1210/jc.2011-0385
  • 3. Bodnar LM , Catov JM, Simhan HN, Holick MF, Powers RW. et al. Maternal vitamin D deficiency increases the risk of preeclampsia. J. Clin. Endocrinol. Metab. 2007; 92(9):3517-3522. doi: 10.1210/jc.2007-0718
  • 4. Santamaria C , Bi WG, Leduc L, Tabatabaei N, Jantchou P. et al. Prenatal vitamin D status and offspring’s growth, adiposity and metabolic health: a systematic review and meta-analysis. Br. J. Nutr. 119(3):310-319. doi: 10.1017/S0007114517003646
  • 5. Aghajafari F, Nagulesapillai T, Ronksley PE, Tough SE, O'Beirne M, et al. Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: Systematic review and meta-analysis of. BMJ. 2013; 1169:1–14. doi: 10.1136/bmj.f1169.
  • 6. Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222.AU American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Obstetrics . Obstet Gynecol. 2020 Jun;135(6):237-260. doi: 10.1097/AOG.2020.
  • 7. AU Waugh JJ, Clark TJ, Divakaran TG, Khan KS, Kilby MD SO. Accuracy of urinalysis dipstick techniques in predicting significant proteinuria in pregnancy. Obstet Gynecol. 2004;103(4): 769-777. doi: 10.1097/01.AOG.0000118311.18958.63
  • 8. Hepner DL, Wilkins-Haug L, Marks PW. Hematologic disease. In Anesthetic and Obstetric Management of High-Risk Pregnancy; Cunningham, F.G., Leveno, K.J., Eds.; Springer: New York, NY, USA, 2004; 309-332.
  • 9.Sibai B, Dekker G, Kupferminc M. Preeclampsia. Lancet 2005; 4;365(9461):785-799. doi: 10.1016/S0140-6736(05)17987-2
  • 10. English FA, Kenny LC, McCarthy FP. Risk factors and effective management of preeclampsia. Integr Blood Press Control. 2015;3;(8):7-12. doi: 10.2147/IBPC.S50641
  • 11.Bartsch E, Medcalf KE, Park AL, Ray JE. Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies. BMJ 2016;19; 353:1753. doi: 10.1136/bmj.i1753
  • 12.Fingar KR , Mabry-Hernandez I, Ngo-Metzger Q , Wolff T , Steiner CA, lixhauser A . Delivery Hospitalizations Involving Preeclampsia and Eclampsia, 2005–2014. HCUP Statistical Brief #222. April 2017
  • 13.Agency for Healthcare Research and Quality, Rockville, MD. www.hcupus.ahrq.gov/reports/statbriefs/sb222-Preeclampsia-Eclampsia-Delivery-Trends.pdf (Accessed on May 18, 2020)
  • 14. Fidan BM, Alkan A,Tosun. Pandemic era: Vitamin D deficiency and insufficiency.2014. https:// doi.org/ 10.4274/tod.94830
  • 15. Kennel KA, Drake MT, Hurley DL.Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc. 2010;85(8):752. doi: 10.4065/mcp.2010.0138.
  • 16. Palacios C,Gonzalez L. Is vitamin D deficiency a major global public health problem?. J. Steroid Biochem. Mol. Biol. 2014;144:138–145. doi: 10.1016/j.jsbmb.2013.11.003
  • 17.Saraf R, Morton S, M Camargo CA, Grant C C. Global summary of maternal and newborn vitamin D status—a systematic review. Matern. Child Nutr. 2016;12:647–668. doi:10.1111/mcn.12210
  • 18.Alagöl F, Shihadeh Y, Boztepe H, Tanakol R, Yarman S, Azizlerli H, et al. Sunlight exposure and vitamin D deficiency in Turkish women. J Endocrinol Invest 2000; 23: 173-177. doi:10.1007/BF03343702
  • 19. Aguilar-Cordero MJ, Cuadrado AL, Villar NM,Ríos AL, Blanco R, , et al. Vitamin D, preeclampsia and prematurity: A systematic review and meta analysis of observational and interventional studies. 2020;87:102707. DOI: 10.1016/j.midw.2020.102707
  • 20. Serrano-Díaz NC , Gamboa-Delgado EM, Domínguez-Urrego CL, Vesga-Varela AL, Serrano-Gómez SE, et al. . Vitamin D and risk of preeclampsia: A systematic review and meta-analysis. Biomedica. 2018;1:43-53. doi: 10.7705/biomedica.v38i0.3683
  • 21. Gala P, Dwarkanath P, Larkin HM, Kurpad A, Mehta S. The role of vitamin D in pre-eclampsia: a systematic review. BMC Pregnancy Childbirth. (2017) 17:231–238. 10.1186/s12884-017-1408-3
  • 22. Baker AM, Haeri S, Camargor CA, Espinola JA, Stuebe AM. A nested case-control study of midgestation vitamin D deficiency and risk of severe preeclampsia. J Clin Endocrinol Metab 2010;95(11):5105-5109. doi: 10.1210/jc.2010-0996
  • 23. Santamaria C, Bi WG, LeduC L, Tabatabaei N, Jantchou P, et al. Prenatal vitamin D status and offspring’s growth, adiposity and metabolic health: a systematic review and meta-analysis. Br. J. Nutr.2018; 119(3):310-319.doi: 10.1017/S0007114517003646
  • 24.V cardi A, Paoletti E, De Nicola L, Mazzaferro S, Russo R, Cozzolino M. Renal anaemia and EPO hyporesponsiveness associated with vitamin D deficiency: The potential role of inflammation. Nephrol Dial Transplant 2013; 28(7):1672-1679. doi: 10.1093/ndt/gft021
  • 25. Shin JY, Shim JY. Low vitamin D levels increase anemia risk in Korean women. Clin Chim Acta 2013;421(5):177-180. doi: 10.1016/j.cca.2013.02.025

Does Vitamin D Status Alter the Severity af Preeclampsia? A Single-Center Case-Control Study

Yıl 2022, Cilt: 4 Sayı: 3, 328 - 332, 22.09.2022
https://doi.org/10.37990/medr.1095867

Öz

Aim: We aimed to investigate the association between vitamin D deficiency and severity of preeclampsia.
Material and Methods: We conducted a case-control study aiming to evaluate vitamin D serum levels in patients with preeclampsia(PE), severe preeclampsia, eclampsia and HELLP syndrome (Hemolysis, Elevated Liver enzymes, Low Platelets). Total number of 69 patients between the ages of 18 and 40 either had a spontaneous vaginal delivery or C-section were included in the study.
Results: The demographic data of the patients were similar, and age was higher in severe PE than in the other groups. When body mass index (BMI) was evaluated, the average BMI of the patients in the severe PE group was found to be significantly higher than PE and similar to the other groups. The average vitamin D levels of all groups was 8.75±3.5 and the mean of severe PE was 6.69±3, which was significantly lower than the other groups. The average vitamin D level in PE was 10.99±2.91, and it was higher than all groups and was significantly higher than patients with severe PE and HELLP syndrome.
Conclusion: We think that there is a significant relationship between the severity of hypertensive disorders that begin during pregnancy and the degree of vitamin D deficiency. We think that the control of vitamin D level and its addition to the treatment will positively affect the course of the disease in order to prevent hypertensive disorders and reduce the severity of disease.

Kaynakça

  • 1. Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J. Steroid Biochem. Mol. Biol.2014; 144:138-145. doi: 10.1016/j.jsbmb.2013.11.003
  • 2. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: An endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011; 96(7):1911-1930. doi: 10.1210/jc.2011-0385
  • 3. Bodnar LM , Catov JM, Simhan HN, Holick MF, Powers RW. et al. Maternal vitamin D deficiency increases the risk of preeclampsia. J. Clin. Endocrinol. Metab. 2007; 92(9):3517-3522. doi: 10.1210/jc.2007-0718
  • 4. Santamaria C , Bi WG, Leduc L, Tabatabaei N, Jantchou P. et al. Prenatal vitamin D status and offspring’s growth, adiposity and metabolic health: a systematic review and meta-analysis. Br. J. Nutr. 119(3):310-319. doi: 10.1017/S0007114517003646
  • 5. Aghajafari F, Nagulesapillai T, Ronksley PE, Tough SE, O'Beirne M, et al. Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: Systematic review and meta-analysis of. BMJ. 2013; 1169:1–14. doi: 10.1136/bmj.f1169.
  • 6. Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222.AU American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Obstetrics . Obstet Gynecol. 2020 Jun;135(6):237-260. doi: 10.1097/AOG.2020.
  • 7. AU Waugh JJ, Clark TJ, Divakaran TG, Khan KS, Kilby MD SO. Accuracy of urinalysis dipstick techniques in predicting significant proteinuria in pregnancy. Obstet Gynecol. 2004;103(4): 769-777. doi: 10.1097/01.AOG.0000118311.18958.63
  • 8. Hepner DL, Wilkins-Haug L, Marks PW. Hematologic disease. In Anesthetic and Obstetric Management of High-Risk Pregnancy; Cunningham, F.G., Leveno, K.J., Eds.; Springer: New York, NY, USA, 2004; 309-332.
  • 9.Sibai B, Dekker G, Kupferminc M. Preeclampsia. Lancet 2005; 4;365(9461):785-799. doi: 10.1016/S0140-6736(05)17987-2
  • 10. English FA, Kenny LC, McCarthy FP. Risk factors and effective management of preeclampsia. Integr Blood Press Control. 2015;3;(8):7-12. doi: 10.2147/IBPC.S50641
  • 11.Bartsch E, Medcalf KE, Park AL, Ray JE. Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies. BMJ 2016;19; 353:1753. doi: 10.1136/bmj.i1753
  • 12.Fingar KR , Mabry-Hernandez I, Ngo-Metzger Q , Wolff T , Steiner CA, lixhauser A . Delivery Hospitalizations Involving Preeclampsia and Eclampsia, 2005–2014. HCUP Statistical Brief #222. April 2017
  • 13.Agency for Healthcare Research and Quality, Rockville, MD. www.hcupus.ahrq.gov/reports/statbriefs/sb222-Preeclampsia-Eclampsia-Delivery-Trends.pdf (Accessed on May 18, 2020)
  • 14. Fidan BM, Alkan A,Tosun. Pandemic era: Vitamin D deficiency and insufficiency.2014. https:// doi.org/ 10.4274/tod.94830
  • 15. Kennel KA, Drake MT, Hurley DL.Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc. 2010;85(8):752. doi: 10.4065/mcp.2010.0138.
  • 16. Palacios C,Gonzalez L. Is vitamin D deficiency a major global public health problem?. J. Steroid Biochem. Mol. Biol. 2014;144:138–145. doi: 10.1016/j.jsbmb.2013.11.003
  • 17.Saraf R, Morton S, M Camargo CA, Grant C C. Global summary of maternal and newborn vitamin D status—a systematic review. Matern. Child Nutr. 2016;12:647–668. doi:10.1111/mcn.12210
  • 18.Alagöl F, Shihadeh Y, Boztepe H, Tanakol R, Yarman S, Azizlerli H, et al. Sunlight exposure and vitamin D deficiency in Turkish women. J Endocrinol Invest 2000; 23: 173-177. doi:10.1007/BF03343702
  • 19. Aguilar-Cordero MJ, Cuadrado AL, Villar NM,Ríos AL, Blanco R, , et al. Vitamin D, preeclampsia and prematurity: A systematic review and meta analysis of observational and interventional studies. 2020;87:102707. DOI: 10.1016/j.midw.2020.102707
  • 20. Serrano-Díaz NC , Gamboa-Delgado EM, Domínguez-Urrego CL, Vesga-Varela AL, Serrano-Gómez SE, et al. . Vitamin D and risk of preeclampsia: A systematic review and meta-analysis. Biomedica. 2018;1:43-53. doi: 10.7705/biomedica.v38i0.3683
  • 21. Gala P, Dwarkanath P, Larkin HM, Kurpad A, Mehta S. The role of vitamin D in pre-eclampsia: a systematic review. BMC Pregnancy Childbirth. (2017) 17:231–238. 10.1186/s12884-017-1408-3
  • 22. Baker AM, Haeri S, Camargor CA, Espinola JA, Stuebe AM. A nested case-control study of midgestation vitamin D deficiency and risk of severe preeclampsia. J Clin Endocrinol Metab 2010;95(11):5105-5109. doi: 10.1210/jc.2010-0996
  • 23. Santamaria C, Bi WG, LeduC L, Tabatabaei N, Jantchou P, et al. Prenatal vitamin D status and offspring’s growth, adiposity and metabolic health: a systematic review and meta-analysis. Br. J. Nutr.2018; 119(3):310-319.doi: 10.1017/S0007114517003646
  • 24.V cardi A, Paoletti E, De Nicola L, Mazzaferro S, Russo R, Cozzolino M. Renal anaemia and EPO hyporesponsiveness associated with vitamin D deficiency: The potential role of inflammation. Nephrol Dial Transplant 2013; 28(7):1672-1679. doi: 10.1093/ndt/gft021
  • 25. Shin JY, Shim JY. Low vitamin D levels increase anemia risk in Korean women. Clin Chim Acta 2013;421(5):177-180. doi: 10.1016/j.cca.2013.02.025
Toplam 25 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Özgün Makaleler
Yazarlar

Duygu Demiröz Aslan 0000-0002-4241-4514

Karolin Ohanoğlu 0000-0002-3223-3293

Mediha Kübra Ceylan 0000-0003-0265-5177

Fatma Ferda Verit 0000-0002-7104-4532

Yayımlanma Tarihi 22 Eylül 2022
Kabul Tarihi 1 Mayıs 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 4 Sayı: 3

Kaynak Göster

AMA Demiröz Aslan D, Ohanoğlu K, Ceylan MK, Verit FF. Does Vitamin D Status Alter the Severity af Preeclampsia? A Single-Center Case-Control Study. Med Records. Eylül 2022;4(3):328-332. doi:10.37990/medr.1095867

 Chief Editors

Assoc. Prof. Zülal Öner
Address: İzmir Bakırçay University, Department of Anatomy, İzmir, Turkey

Assoc. Prof. Deniz Şenol
Address: Düzce University, Department of Anatomy, Düzce, Turkey

E-mail: medrecsjournal@gmail.com

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