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Investigation of Age- and Gender-Related Changes in Anatomical Variables of the Cerebellum in Healthy Adults Using MR Imaging

Yıl 2025, Cilt: 7 Sayı: 1, 234 - 239, 15.01.2025
https://doi.org/10.37990/medr.1595432

Öz

Aim: The aging process and gender are thought to cause changes in anatomical regions of the brain. The present study was designed to present age- and gender-related changes in the morphometric characteristics of the cerebellum, which is known to be mainly responsible for the coordination of the skeletal system and balance.
Material and Method: Brain magnetic resonance (MR) images of healthy individuals aged 25-55 years were analyzed. MCRae line (MCL), Klaus index (KI), clivus length (LC), supraocciput length (LSO), diameter of the posterior cranial fossa (PDFC), height of the posterior cranial fossa (PHFC), lateral diameter of the cerebellum (LDC), cerebellum height (HCL), cerebellum width (WCL), cerebrum height (HC), anterior dural angle of the cerebellum (ADAC), angle of the cerebellar clivus (ACC), anteroposterior diameter of the right cerebellar hemisphere (RCHD) and anteroposterior diameter of the left cerebellar hemisphere (LCHD) variables were measured.
Results: It has been determined that the difference between the groups for age, MCL, LSO, PHFC, HCL variables is statistically significant. The difference between genders is statistically significant for KI, LC, PHFC, LDC, WCL, HC, RCHD, LCHD variables in the first group, MCL, KI, LDC, HC, LCHD variables in the second group, LC, LDC, HCL, WCL, HC, ACC, LCHD variables in the third group.
Conclusion: Overall, the results show that aging and gender cause changes in cerebellum morphometry in healthy individuals for the Bolu (Türkiye) population.

Kaynakça

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  • Taşdemir R, Uysal İİ, Durduran SS. Effects of age and sex on cerebellum and ventral pons volume- MRI study. Exp Appl Med Sci. 2020;1:45-51.
  • Tiemeier H, Lenroot RK, Greenstein DK, et al. Cerebellum development during childhood and adolescence: a longitudinal morphometric MRI study. Neuroimage. 2010;49:63-70.
  • Kim JH, Park JW, Tae WS, Rhyu IJ. Cerebral cortex changes in basketball players. J Korean Med Sci. 2022;21:37:e86.
  • Rudolph S, Badura A, Lutzu S, et al. Cognitive-affective functions of the cerebellum. J Neurosci. 2023; 43:7554-64.
  • Diedrichsen J, King M, Hernandez-Castillo C, et al. Universal transform or multiple functionality? Understanding the contribution of the human cerebellum across task domains. Neuron. 2019;102:918-28.
  • Zang Y, De Schutter E. Recent data on the cerebellum require new models and theories. Current Opinion in Neurobiology. 2023;82:102765.
  • Zhai H, Fan W, Xiao Y, et al. Voxel based morphometry of grey matter structures in Parkinson’s Disease with wearing of. Brain Imaging Behav. 2023;17:725-37.
  • Liu HY, Lee PL, Chou KH, et al. The cerebellum is associated with 2-year prognosis in patients with high-frequency migraine. J Headache Pain. 2020;21:29.
  • Syaifullah AH, Shiino A, Fujiyoshi A, et al. Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men. Alcohol. 2021;90:57-65.
  • Durazzo TC, Mon A, Pennington D, et al. Interactive effects of chronic cigarette smoking and age on brain volumes in controls and alcohol-dependent individuals in early abstinence. Addict Biol. 2012;19:132-43.
  • Hänggi J, Langer N, Lutz K, et al. Structural brain correlates associated with professional handball playing. PLoS One. 2015;10:e0124222.
  • Park IS, Han JW, Lee KJ, et al. Evaluation of morphological plasticity in the cerebella of basketball players with MRI. J Korean Med Sci. 2006;21:342-6.
  • Iskusnykh IY, Zakharova AA, Kryl'skii ED, Popova TN. Aging, neurodegenerative disorders, and cerebellum. Int J Mol Sci. 2024;25:1018.
  • Wei Y, Jiang H, Shi Y, et al. Age-related alterations in the retinal microvasculature, microcirculation, and microstructure. Invest Ophthalmol Vis Sci. 2017;58:3804-17. Erratum in: Invest Ophthalmol Vis Sci. 2017;58:4247.
  • Karaca O, Demirtas D, Ozcan E, et al. Volumetric evaluation of substantia nigra in major depressive disorder using atlas-based method. Med Records. 2024;6:190-5.
  • Johnstone T, van Reekum CM, Oakes TR, Davidson RJ. The voice of emotion: an FMRI study of neural responses to angry and happy vocal expressions. Soc Cogn Affect Neurosci. 2006;1:242-9.
  • Baykan AH, Karabaş SA, Doğan Z, et al. Assessment of age- and sex-dependent changes of cerebellum volume in healthy individuals using magnetic resonance imaging. J Surg Med. 2019;3:481-4.
  • Sang F, Chen Y, Chen K, et al. Sex differences in cortical morphometry and white matter microstructure during brain aging and their relationships to cognition. Cereb Cortex. 2021;31:5253-62.
  • Stalter J, Yogeswaran V, Vogel W, et al. The impact of aging on morphometric changes in the cerebellum: a voxel-based morphometry study. Front Aging Neurosci. 2023;15:1078448.
  • Wang Y, Teng Y, Liu T, et al. Morphological changes in the cerebellum during aging: evidence from convolutional neural networks and shape analysis. Front Aging Neurosci. 2024;16:1359320.
  • Gao Y, Tang Y, Zhang H, et al. Sex differences of cerebellum and cerebrum: evidence from graph convolutional network. Interdiscip Sci. 2022;14:532-44.
  • Hayretdağ Örs C, Tiryakioğlu NO, Varol T. Examination of age related volume changes in brain by magnetic resonance imaging method. IGUSABDER. 2018;5:407-20.
  • Han S, An Y, Carass A. et al. Longitudinal analysis of regional cerebellum volumes during normal aging. Neuroimage. 2020;220:117062.
  • Uwisengeyimana JD, Nguchu BA, Wang Y, et al. Cognitive function and cerebellar morphometric changes relate to abnormal intra-cerebellar and cerebro-cerebellum functional connectivity in old adults. Exp Gerontol. 2020;140:111060.
  • Sied Ahmed HOM, Hassan HA, Ayad CE. Norms for cerebellum in Sudanese –a morphometric MRI based study. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS). 2017;16:24-31.
  • Öksüzler M, Polat S, Çay Eİ, Göker P. The relationship of the posterior cranial fossa with age and sex. Int J Morphol. 2021;39:1371-82.
  • Pavithra A.S., Premavathy D. Estimation of McRae line, McGregor line, and Chamberlain line in South Indian dry skull. Drug Invention Today. 2019;12:848-50.
  • Taştemur Y, Sabanciogullari V, Salk I. et al. The relationship of the posterior cranial fossa, the cerebrum and cerebellum morphometry with tonsiller herniation. Iran J Radiol. 2017;14:e24436.
  • Alkoç OA, Songur A, Eser O, et al. Stereological and morphometric analysis of MRI Chiari malformation type-1. J Korean Neurosurg Soc. 2015;58:454-61.
  • Vurallı D, Öksüzler M. Radiological determination of fossa cranii posterior morphometry in Chiari malformation type I. Cukurova Med J. 2022;47:1067-72.
Yıl 2025, Cilt: 7 Sayı: 1, 234 - 239, 15.01.2025
https://doi.org/10.37990/medr.1595432

Öz

Kaynakça

  • Dekeyzer S, Vanden Bossche S, De Cocker L. Anything but little: a pictorial review on anatomy and pathology of the cerebellum. Clin Neuroradiol. 2023;33:907-29.
  • Taşdemir R, Uysal İİ, Durduran SS. Effects of age and sex on cerebellum and ventral pons volume- MRI study. Exp Appl Med Sci. 2020;1:45-51.
  • Tiemeier H, Lenroot RK, Greenstein DK, et al. Cerebellum development during childhood and adolescence: a longitudinal morphometric MRI study. Neuroimage. 2010;49:63-70.
  • Kim JH, Park JW, Tae WS, Rhyu IJ. Cerebral cortex changes in basketball players. J Korean Med Sci. 2022;21:37:e86.
  • Rudolph S, Badura A, Lutzu S, et al. Cognitive-affective functions of the cerebellum. J Neurosci. 2023; 43:7554-64.
  • Diedrichsen J, King M, Hernandez-Castillo C, et al. Universal transform or multiple functionality? Understanding the contribution of the human cerebellum across task domains. Neuron. 2019;102:918-28.
  • Zang Y, De Schutter E. Recent data on the cerebellum require new models and theories. Current Opinion in Neurobiology. 2023;82:102765.
  • Zhai H, Fan W, Xiao Y, et al. Voxel based morphometry of grey matter structures in Parkinson’s Disease with wearing of. Brain Imaging Behav. 2023;17:725-37.
  • Liu HY, Lee PL, Chou KH, et al. The cerebellum is associated with 2-year prognosis in patients with high-frequency migraine. J Headache Pain. 2020;21:29.
  • Syaifullah AH, Shiino A, Fujiyoshi A, et al. Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men. Alcohol. 2021;90:57-65.
  • Durazzo TC, Mon A, Pennington D, et al. Interactive effects of chronic cigarette smoking and age on brain volumes in controls and alcohol-dependent individuals in early abstinence. Addict Biol. 2012;19:132-43.
  • Hänggi J, Langer N, Lutz K, et al. Structural brain correlates associated with professional handball playing. PLoS One. 2015;10:e0124222.
  • Park IS, Han JW, Lee KJ, et al. Evaluation of morphological plasticity in the cerebella of basketball players with MRI. J Korean Med Sci. 2006;21:342-6.
  • Iskusnykh IY, Zakharova AA, Kryl'skii ED, Popova TN. Aging, neurodegenerative disorders, and cerebellum. Int J Mol Sci. 2024;25:1018.
  • Wei Y, Jiang H, Shi Y, et al. Age-related alterations in the retinal microvasculature, microcirculation, and microstructure. Invest Ophthalmol Vis Sci. 2017;58:3804-17. Erratum in: Invest Ophthalmol Vis Sci. 2017;58:4247.
  • Karaca O, Demirtas D, Ozcan E, et al. Volumetric evaluation of substantia nigra in major depressive disorder using atlas-based method. Med Records. 2024;6:190-5.
  • Johnstone T, van Reekum CM, Oakes TR, Davidson RJ. The voice of emotion: an FMRI study of neural responses to angry and happy vocal expressions. Soc Cogn Affect Neurosci. 2006;1:242-9.
  • Baykan AH, Karabaş SA, Doğan Z, et al. Assessment of age- and sex-dependent changes of cerebellum volume in healthy individuals using magnetic resonance imaging. J Surg Med. 2019;3:481-4.
  • Sang F, Chen Y, Chen K, et al. Sex differences in cortical morphometry and white matter microstructure during brain aging and their relationships to cognition. Cereb Cortex. 2021;31:5253-62.
  • Stalter J, Yogeswaran V, Vogel W, et al. The impact of aging on morphometric changes in the cerebellum: a voxel-based morphometry study. Front Aging Neurosci. 2023;15:1078448.
  • Wang Y, Teng Y, Liu T, et al. Morphological changes in the cerebellum during aging: evidence from convolutional neural networks and shape analysis. Front Aging Neurosci. 2024;16:1359320.
  • Gao Y, Tang Y, Zhang H, et al. Sex differences of cerebellum and cerebrum: evidence from graph convolutional network. Interdiscip Sci. 2022;14:532-44.
  • Hayretdağ Örs C, Tiryakioğlu NO, Varol T. Examination of age related volume changes in brain by magnetic resonance imaging method. IGUSABDER. 2018;5:407-20.
  • Han S, An Y, Carass A. et al. Longitudinal analysis of regional cerebellum volumes during normal aging. Neuroimage. 2020;220:117062.
  • Uwisengeyimana JD, Nguchu BA, Wang Y, et al. Cognitive function and cerebellar morphometric changes relate to abnormal intra-cerebellar and cerebro-cerebellum functional connectivity in old adults. Exp Gerontol. 2020;140:111060.
  • Sied Ahmed HOM, Hassan HA, Ayad CE. Norms for cerebellum in Sudanese –a morphometric MRI based study. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS). 2017;16:24-31.
  • Öksüzler M, Polat S, Çay Eİ, Göker P. The relationship of the posterior cranial fossa with age and sex. Int J Morphol. 2021;39:1371-82.
  • Pavithra A.S., Premavathy D. Estimation of McRae line, McGregor line, and Chamberlain line in South Indian dry skull. Drug Invention Today. 2019;12:848-50.
  • Taştemur Y, Sabanciogullari V, Salk I. et al. The relationship of the posterior cranial fossa, the cerebrum and cerebellum morphometry with tonsiller herniation. Iran J Radiol. 2017;14:e24436.
  • Alkoç OA, Songur A, Eser O, et al. Stereological and morphometric analysis of MRI Chiari malformation type-1. J Korean Neurosurg Soc. 2015;58:454-61.
  • Vurallı D, Öksüzler M. Radiological determination of fossa cranii posterior morphometry in Chiari malformation type I. Cukurova Med J. 2022;47:1067-72.
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Anatomi
Bölüm Özgün Makaleler
Yazarlar

Gülçin Ray 0000-0002-0417-1806

Abdullah Ray 0000-0002-8124-6402

İbrahim Kürtül 0000-0002-9218-6468

Saadet Erdem 0000-0001-5631-3493

Basel Malaysheh 0009-0004-4017-7211

Yayımlanma Tarihi 15 Ocak 2025
Gönderilme Tarihi 6 Aralık 2024
Kabul Tarihi 3 Ocak 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 7 Sayı: 1

Kaynak Göster

AMA Ray G, Ray A, Kürtül İ, Erdem S, Malaysheh B. Investigation of Age- and Gender-Related Changes in Anatomical Variables of the Cerebellum in Healthy Adults Using MR Imaging. Med Records. Ocak 2025;7(1):234-239. doi:10.37990/medr.1595432

 Chief Editors

Assoc. Prof. Zülal Öner
Address: İzmir Bakırçay University, Department of Anatomy, İzmir, Turkey

Assoc. Prof. Deniz Şenol
Address: Düzce University, Department of Anatomy, Düzce, Turkey

Editors
Assoc. Prof. Serkan Öner
İzmir Bakırçay University, Department of Radiology, İzmir, Türkiye

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