The relationship between Thyroid Stimulating Hormone - Anti Mullerian Hormone in women infertility

Yıl 2019, Cilt: 12 Sayı: 2, 284 - 292, 30.08.2019

İlker Çalıkoğlu , Gürkan Yazıcı , Güzin Aykal Bahar Taşdelen

https://doi.org/10.26559/mersinsbd.558520

Öz

Objective: Hypothyroidism
may be a risk for infertility, the relationship between increased Thyroid
Stimulating Hormone (TSH) and
ovarian reserve is discussed. Anti-Mullarian Hormone (AMH) is a good predictor of ovarian reserve.
We
investigated the relationship between TSH and AMH levels
in infertile women and the effect of TSH on fertility. Methods: Age, weight, height, additional diseases and treatment
history of patients aged 19-40 years who were admitted to Mersin City Hospital
Gynecology and Obstetrics Clinic between 01.01.2018 and 01.03.2019 were
obtained from hospital records. Women data with similar demographic
characteristics who were healthy, had at least one birth, applies to the same
center for control on the same date were taken from records. Patients with
polycystic ovary, hirsutism, primary amenorrhea, menopausal conditions,
endometriosis, known thyroid disease and treatment, cancer, obese, cachectic
were not included. Serum AMH and TSH levels were recorded. Results: The mean serum AMH and TSH levels of infertile (160) and
fertile (34) women were compared. Mean AMH level in infertil women was
3.01±1.56 and 1.65±1.70ng/ml in fertilizers (p=0.00002). TSH levels in infertil
women were higher (2.91±1.26μIU/mL) than fertilizers (1.76±0.72μIU/mL) and it
was different at the statistical border (p=0.05). AMH-age
(r=-0.34, p=0.01) and AMH-TSH levels were inversely correlated in infertil women
(r=-0.20, p=0.0001). In fertilizers AMH levels were decreased with age
(r=-0.40, p=0.01), but there was no correlation between AMH-TSH levels
(r=-0.17,p=0,31). Conclusion: Our study
suggests negative relation between AMH-TSH levels in infertile women and TSH
elevation should not be overlooked in the etiology of infertility.

Anahtar Kelimeler

Thyroid Stimulating hormone, Anti-Mullarian hormone, infertility

Kadın infertilitesinde Tiroid Stimülan Hormon - Anti Müllerian hormon ilişkisi

Öz

Amaç
Hipotiroidizmin infertilitede risk
faktörü olabileceği, artmış Tiroid Stimulan
Hormon (TSH) düzeyinin over rezerviyle ilişkisi tartışılmaktadır. Anti
Müllerian Hormon (AMH) over rezervini belirlemede iyi bir belirteçtir. İnfertil kadınlarda serum ortalama TSH ile AMH düzeyleri
arasındaki ilişkiyi ve TSH'ın fertiliteye etkisini araştırdık. Yöntem: Mersin Şehir Hastanesi Kadın Hastalıkları Doğum
polikliniğine 01.01.2018-1.03.2019
arasında başvuran, infertilite tanılı, 19-40 yaş kadınların yaş, kilo, boy, ek
hastalık, tedavi öyküleri ve kontrol amacıyla başvuran sağlıklı, en az bir
doğum yapmış, benzer demografik özelliklere sahip kadınların verileri hastane
kayıtlarından alındı. Polikistik Over, hirsutism, amenore, menapozal durumlar,
endometriozis, bilinen tiroid bezi hastalığı olanlar ve tedavi alanlar, kanser
tanılılar, obezler, kaşektikler çalışmadan çıkarıldı. Başvuruda serum AMH
ve TSH düzeyleri bakılmışların değerleri
kaydedildi. Bulgular: İnfertil
(160) ve fertil (34) kadına ait ortalama serum AMH ve TSH düzeyleri karşılaştırıldı. İnfertillerde AMH düzeyi 1.65±1.70 fertillerde 3.01±1.56 ng/ml
olup, istatistiksel farklıydı (p=0.00002). İnfertillerdeki TSH düzeyi (2.20±1.26 μIU/mL) fertillerden
(1.76±0.72 μIU/mL) yüksek olup istatistiksel sınırda farklıydı (p=0.05).
İnfertillerde AMH-yaş (r=-0.34, p=0.01) ve AMH-TSH
düzeyleri ters korele bulundu (r=-0.20, p=0,0001). Fertillerde serum AMH düzeyi yaş ile azalırken (r=-0.40, p=0.01),
AMH-TSH düzeyleri arasında korelasyon
izlenmedi (r=-0.17, p=0.31). Sonuç:
Çalışmamız infertillerde AMH ve TSH düzeyleri
arasındaki negatif ilişkiyi ve infertilite etiyolojisinde TSH yüksekliğinin gözden kaçırılmaması
gerektiğini düşündürmektedir.

Anahtar Kelimeler

Tiroid Stimülan Hormon, Anti Müllerian Hormon, infertilite

Kaynakça

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