Clinical and pathological characteristics of triple-negative breast cancer patients: A single-center experience

Yıl 2019, Cilt: 12 Sayı: 3, 478 - 488, 31.12.2019

Aydan Akdeniz , Özden Özen Altundağ

https://doi.org/10.26559/mersinsbd.539828

Öz

Aim: Triple negative
breast cancer in which estrogen, progesterone receptors and c-erbB2
overexpression are negative, seems to have different clinical course and
recurrence pattern. We retrospectively evaluated clinical demographic and
pathological characteristics of triple negative breast cancers and investigated
the association of these characteristics with OS and PFS, and also we aimed to
identify prognostic factors, chemotherapy effects, survival rates, and the
factors that effect survival rates. 

Method: 59 patients with triple negative breast
cancer patients followed in Başkent University Hospital between 1997-2009 were
evoluated retrospectively. Results: The median age of
patients was 49. Median follow-up duration was 27 months (0.27-132 months). Two
patients died during the follow-up. Invasive ductal carcinoma pathology was
reported in 38 patients, invasive lobular in 3 patients, medullary in 5
patients. Almost half of the patients had LVI. 79% of patients had a T2
disease. 30% of patients’ tumor histological grade was III. Cancer history in
the family was present in 95% of patients. Almost half of the patients had
stage II disease. Adjuvant chemotherapy was given to 43 patients. Relapses were
observed in 15 patients.The most common metastatic site was lung. Patients
having high grade tumor, >3 (+) lymph nodes, younger age have higher chance
of relapse during follow-up. Conclusions:
In accordance with the literature, our triple negative breast cancer patients
showed more aggressive characteristics. Although median follow-up is short,
one-fourth of the patients having recurrence support natue of the triple
negative breast cancer patients. In our study, triple negative patients had
younger age at diagnosis, high grade tumors and more tendency to metastasize to
visceral organs.

Anahtar Kelimeler

Estrogen receptors, progesteron receptors, cerbB2 receptor

Üçlü negatif meme kanserlerinin klinik ve demografik verileri-tek merkez deneyimi

Öz

Giriş: Östrojen
progesteron ve c-erbB2 ekspresyonu negatif olan üçlü negatif meme kanserleri,
diğer meme kanser türlerine göre daha kötü prognoza sahiptir. Bu çalışmada üçlü
negatif meme kanserlerinin klinik demografik ve patolojik karakteristikleri ve
bu karakteristiklerin genel sağkalım ve progresyonsuz sağkalımla olan ilişkisi
retrospektif olarak incelenerek prognostik faktörler, kemoterapi etkinlikleri
ve sağkalım oranları ile sağkalıma etki eden faktörlerin
belirlenmesi amaçlanmıştır. Yöntem: Başkent Üniversitesi Hastanesinde 1997-2009 arasında takipli
üçlü negatif meme kanserli hasta retrospektif olarak incelendi. Bulgular: Hastaların median yaşları 49
idi. Median takip süresi 27 ay idi (0.27-132 ay). İki hasta takip sırasında ex
oldu. 38 hastada invaziv duktal karsinom, üç hastada invaziv lobuler karsinom,
beş hastada meduller karsinom saptandı. Hastaların neredeyse yarısında lenf
nodu invazyonu vardı. %79 hastanın T2 hastalığı vardı. Hastaların %30 unun
tümör histolojik derece III, ve neredeyse yarısında evre II hastalık vardı. %95
inde ailede kanser öyküsü mevcuttu. Adjuvan kemoterapi 43 hastaya verildi. 15
hastada relaps gözlendi. En sık metastaz akciğere idi. Yüksek dereceli tümörü
olan, üçden fazla lenf nodu tutulan, ve genç yaşta olanların takiplerde daha
fazla relaps olduğu görüldü. Tartışma:
Literatürle uyumlu bir şekilde, bizim üçlü negatif meme kanserli hastalarımız
da agresif karakteristikliydi. Median takip süresi kısa olmasına rağmen üçlü
negatif meme kanserli hastaların doğasını destekleyecek şekilde ¼ hastada
rekürrens izlendi. Çalışmamızda hastalarımız daha genç yaşta tanı almış, yüksek
dereceli tümörlü ve visseral organlara metastaz yapma eğilimleri daha fazla idi. 

Anahtar Kelimeler

östrojen reseptöü, progesteron reseptörü, cerbB2 reseptörü

Kaynakça

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