Is it possible that biochemical markers in first-trimester screening test predict gestational diabetes mellitus?

Yıl 2024, Cilt: 17 Sayı: 1, 119 - 129, 30.04.2024

Yusuf Dal , Sebnem Karagun , Fatih Akkuş , Hakan Aytan , Ayhan Coskun

Öz

Aim: Early diagnosis and treatment are critical to minimize the complications of gestational diabetes mellitus (GDM). Therefore, the present study aimed to determine whether first-trimester screening test biochemical markers could be an early predictive model for GDM. Method: This retrospective study was performed by accessing the electronic media data of 116 pregnant women who underwent first-trimester screening tests at the 11th-14th weeks of gestation and were diagnosed with GDM at the 24th-28th weeks and 65 pregnant women who did not receive this diagnosis. Demographic characteristics of GDM and control groups, first-trimester screening test biochemical markers, oral glucose tolerance test (OGTT), and hemoglobin A1c values were recorded, and intergroup comparison was made. Results: There was no statistically significant difference between the groups regarding first-trimester biochemical markers (p>0.05). A negative correlation was determined between pregnancy-associated plasma protein A (PAPP-A) and free beta- human chorionic gonadotropin (β-HCG) multiple of median (MoM) values and OGTT fasting value (p<0.05). Conclusion: In this study, we concluded that first-trimester biochemical markers could not predict the development of GDM.

Anahtar Kelimeler

Gestational diabetes mellitus, first-trimester screening test, pregnancy-associated plasma protein A, human chorionic gonadotropin, oral glucose tolerance test

Birinci trimester tarama testindeki biyokimyasal belirteçlerin gestasyonel diabetes mellitusu öngörmesi mümkün mü?

Öz

Amaç: Gestasyonel diabetes mellitus (GDM) komplikasyonlarını en aza indirmek için erken tanı ve tedavi önemlidir. Bu nedenle bu çalışmada birinci trimester tarama testi biyokimyasal belirteçlerinin GDM için erken öngörü modeli olup olamayacağını belirlemeyi hedefledik. Yöntem: Bu retrospektif çalışma 11-14. gebelik haftasında birinci trimester tarama testi yapılan ve 24-28. gebelik haftasında GDM tanısı konulan 116 gebe ile bu tanıyı almayan 65 gebenin elektronik ortamda verilerine ulaşılarak yapıldı. GDM ve kontrol grubunun demografik özellikleri ile birlikte birinci trimester tarama testi biyokimyasal belirteçleri, oral glukoz tolerans testi (OGTT) ve hemoglobin A1c değerleri kaydedildi ve gruplar arası karşılaştırması yapıldı. Bulgular: Gruplar arasında birinci trimester biyokimyasal belirteçleri arasında istatistiksel olarak anlamlı bir fark yoktu (p>0.05). Gebelikle ilişkili plazma protein A (PAPP-A) ve serbest beta- insan koryonik gonadotropin (β-hCG) medyan kat sayısı (MoM) değerleri ile OGTT açlık değeri arasında negatif yönde bir korelasyon saptandı (p<0.05). Sonuç: Çalışmamızda birinci trimester biyokimyasal belirteçlerinin, gelişecek GDM’ yi öngöremeyeceği sonucuna vardık.

Anahtar Kelimeler

Gestasyonel diabetes mellitus, birinci trimester tarama testi, gebelikle ilişkili plazma protein A, insan koryonik gonadotropin, oral glukoz tolerans testi

Kaynakça

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