Do Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio Predict the Hardness of Kidney Stone

Yıl 2021, Cilt: 12 Sayı: 43, 59 - 64, 19.08.2021

Onur Karslı , Murat Üstüner , Ahmed Ömer Halat , Levent Özcan , Fatih Gokalp , Ömer Koraş , Bekir Voyvoda , Ömür Memik

https://doi.org/10.17944/mkutfd.873615

Öz

Objective: The Hounsfield unit (HU) is the most common value to assess the stone formation and a predictive factor for the management success. In this study, it was aimed to investigate the prediction of the hardness of the stone using systemic inflammatory response markers.Methods: 192 patients (61 female and 131 male) patients who underwent conventional percutaneous nephrolithotomy (PCNL) between 2015 and 2020 were reviewed retrospectively. Patients with malignancy and history of preoperative urinary tract infection were excluded from this study. Patients’ neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and HU of the kidney Stone, which was obtained from NCCT, were recorded to data.Results: The mean age was 47.2 ± 14.11 (11-82) years. The average HU value of the patients’ stones was 1135.47 ± 362.19 (348-2096). The location of the stones was grouped as pelvis (n:64, 33.3%), single calyx (n:14, 7.2%), two calyces (n:93, 48.4%) and staghorn (n:21, 10.9%). In subgroup analysis, when divided by stone location, a negative correlation was found between the HU and N/L ratio in the single calyceal stone group, and a positive correlation was found between the HU and N/L ratio for pelvis and staghorn stones. Among these correlations, only the positive correlation between the HU and N/L ratio in the pelvic stone group was statistically significant (r=0.318, p=0.03). Assuming an arbitrary cut-off value for HU below 1000, there was no significant correlation between NLR and HU (r=0.266, p=0.171). However, HU above 1000, there was a significant positive correlation between NLR and HU (r=0.145, p=0.045).Conclusion: The findings suggest that NLR could be used as a biomarker to choose appropriate management and be helpful to anticipate the hardness of kidney stones by predicting the HU value.

Anahtar Kelimeler

Kidney Calculi, Hounsfield Unit, Urolithiasis, Neutrophil

Destekleyen Kurum

None

Trombosit-Lenfosit Oranı ve Nötrofil-Lenfosit Oranı Böbrek Taşının Sertliğini Öngörür mü?

Öz

Amaç: Hounsfield ünitesi (HU), taş oluşumunu değerlendirmek için en yaygın değer ve aynı zamanda yönetim başarısı için öngörücü bir faktördür. Bu çalışmada, sistemik inflamatuar yanıt belirteçleri kullanarak taşın sertliğini tahmin etmeyi amaçladık.Yöntem: 2015 ve 2020 yılları arasında konvansiyonel perkütan nefrolitotomi uygulanan 192 hastaya (61 kadın ve 131 erkek) ait veri retrospektif olarak gözden geçirildi. Malignite, preoperatif idrar kültürü pozitif olan hastalar çalışma dışı bırakıldı. Hastaların nötrofil lenfosit oranı (NLR), trombosit lenfosit oranı (PLR) ve NCCT’den elde edilen böbrek taşı Hounsfield Ünitesi (HU) verilere kaydedildi.Bulgular: Ortalama yaş 47,2 ± 14,11 (11-82) yıldı. Hastaların taşlarının ortalama HU değeri 1135,47 ± 362,19 (348-2096) olarak bulundu. Taşların yeri pelvis (n: 64, %33,3), tek kaliks (n: 14, %7,2), iki kaliks (n: 93, %48,4) ve staghorn (n: 21, %10,9) olarak gruplandı. Alt grup analizinde taş lokalizasyonuna göre, pelvis ve staghorn taşlar için HU ve NLR arasında pozitif bir korelasyon bulundu. Bu korelasyonlar arasında sadece pelvis taş grubunda HU ve NLR arasındaki pozitif korelasyon istatistiksel olarak anlamlıydı (r=0.318, p=0.03). HU için 1000’in altında bir kesme değeri varsayıldığında ise, NLR ve HU arasında anlamlı bir korelasyon yoktu (r=0.266, p=0.171). Bununla birlikte, HU 1000’in üzerinde, NLR ve HU arasında anlamlı bir pozitif korelasyon vardır (r=0.145, p=0.045).Sonuç: Bu çalışma, NLR’nin uygun tedaviyi seçmek için bir biyobelirteç olarak kullanabileceğini ve HU değerini tahmin ederek böbrek taşının sertliğini tahmin etmeye yardımcı olabileceğini gösterdi.

Anahtar Kelimeler

Böbrek Taşı, Hounsfield Ünitesi, Ürolitiyazis, Nötrofil

Kaynakça

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