Diet induced weight loss reduces mean platelet volume in people with obesity

Yıl 2016, Cilt: 3 Sayı: 2, 98 - 102, 15.02.2016

Huseyin Kurt , Davut Demirkiran

Öz

Objectives: To investigate is there a relationship between obesity parameters, mean platelet volume (MPV) and neutrophil lymphocyte ratio (NLR), and to examine is there a change in MPV and NLR level with weight loss.

Material and Methods: The retrospective study consisted of two groups as the group losing weight after 24 weeks of diet (WLG) and the control group not losing weight (CG). Body mass index (BMI), MPV, NLR and lipid values of each group were recorded at the beginning and at the end of the study.

Results: The study consisted of 186 individuals 94 of whom were in WLG and 92 were in CG. There was a statistically significant positive correlation between the initial value of MPV and BMI in WLG (p <0.05). There was a significant difference existed in the initial and final lipid parameters of WLG (p<0.0001). Changes in initial and final MPV values in WLG and CG were different from each other (p <0.01). The difference between the initial and final MPV values and BMI values in WLG was statistically significant (P <0.001). No significant correlation was found between obesity and weight loss with NLR.

Conclusions: There was a statistically significant correlation between MPV and BMI. MPV levels decreased in obese individuals with weight loss. No correlation existed between BMI and NLR.

Anahtar Kelimeler

Diet, weight loss, mean platelet volume, neutrophil lymphocyte ratio, obesity, body mass index

Diet induced weight loss reduces mean platelet volume in people with obesity

Öz

Kaynakça

• Folsom AR, Aleksic N, Catellier D, Juneja HS, Wu KK. C-reactive protein and incident coronary heart disease in the Atherosclerosis Risk In Communities (ARIC) study. American heart journal. 2002;144(2):233-8.
• Folsom AR, Wu KK, Rosamond WD, Sharrett AR, Chambless LE. Prospective study of hemostatic factors and incidence of coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study. Circulation. 1997;96(4):1102-8.
• Adams KF, Schatzkin A, Harris TB, Kipnis V, Mouw T, Ballard-Barbash R, et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. The New England journal of medicine. 2006;355(8):763-78.
• Waxman A. Prevention of chronic diseases: WHO global strategy on diet, physical activity and health. Food and nutrition bulletin. 2003;24(3):281-4.
• Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2006;113(6):898-918.
• Elgazar-Carmon V, Rudich A, Hadad N, Levy R. Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding. Journal of lipid research. 2008;49(9):1894-903.
• Pecht T, Gutman-Tirosh A, Bashan N, Rudich A. Peripheral blood leucocyte subclasses as potential biomarkers of adipose tissue inflammation and obesity subphenotypes in humans. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2014;15(4):322-37.
• Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 1996;7(2):157-61.
• Cay S, Biyikoglu F, Cihan G, Korkmaz S. Mean platelet volume in the patients with cardiac syndrome X. Journal of thrombosis and thrombolysis. 2005;20(3):175-8.
• Jagroop IA, Clatworthy I, Lewin J, Mikhailidis DP. Shape change in human platelets: measurement with a channelyzer and visualisation by electron microscopy. Platelets. 2000;11(1):28-32.
• Coban E, Ozdogan M, Yazicioglu G, Akcit F. The mean platelet volume in patients with obesity. International journal of clinical practice. 2005;59(8):981-2.
• Talukdar S, Oh da Y, Bandyopadhyay G, Li D, Xu J, McNelis J, et al. Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nature medicine. 2012;18(9):1407-12.
• Dixon JB, O'Brien PE. Obesity and the white blood cell count: changes with sustained weight loss. Obesity surgery. 2006;16(3):251-7.
• Gibson PH, Croal BL, Cuthbertson BH, Small GR, Ifezulike AI, Gibson G, et al. Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting. American heart journal. 2007;154(5):995-1002.
• Gerrior S, Juan W, Basiotis P. An easy approach to calculating estimated energy requirements. Preventing chronic disease. 2006;3(4):A129.
• Davi G, Patrono C. Platelet activation and atherothrombosis. The New England journal of medicine. 2007;357(24):2482-94.
• Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. Journal of thrombosis and haemostasis : JTH. 2010;8(1):148-56.
• Kutlucan A, Bulur S, Kr S, Bulur S, Onder E, Aslantas Y, et al. The relationship between mean platelet volume with metabolic syndrome in obese individuals. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2012;23(5):388-90.
• Tavil Y, Sen N, Yazici HU, Hizal F, Abaci A, Cengel A. Mean platelet volume in patients with metabolic syndrome and its relationship with coronary artery disease. Thrombosis research. 2007;120(2):245-50.
• Toplak H, Wascher TC. Influence of weight reduction on platelet volume: different effects of a hypocaloric diet and a very low calorie diet. European journal of clinical investigation. 1994;24(11):778-80.
• Coban E, Yilmaz A, Sari R. The effect of weight loss on the mean platelet volume in obese patients. Platelets. 2007;18(3):212-6.
• Duffy BK, Gurm HS, Rajagopal V, Gupta R, Ellis SG, Bhatt DL. Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention. The American journal of cardiology. 2006;97(7):993-6.
• Ryder E, Diez-Ewald M, Mosquera J, Fernandez E, Pedreanez A, Vargas R, et al. Association of obesity with leukocyte count in obese individuals without metabolic syndrome. Diabetes & metabolic syndrome. 2014;8(4):197-204.
• Agacayak E, Tunc SY, Sak S, Basaranoglu S, Yuksel H, Turgut A, et al. Levels of Neopterin and other Inflammatory Markers in Obese and Non-Obese Patients with Polycystic Ovary Syndrome. Medical science monitor : international medical journal of experimental and clinical research. 2015;21:2446-55.
• Bahadir A, Baltaci D, Turker Y, Turker Y, Iliev D, Ozturk S, et al. Is the neutrophil-to-lymphocyte ratio indicative of inflammatory state in patients with obesity and metabolic syndrome? Anatolian journal of cardiology. 2015;15(10):816-22.