Patient Presenting with Cough and Diagnosed as Ewing Sarcoma

Yıl 2025, Sayı: 3, 139 - 144, 14.03.2025

Şeyda Gökalp , Hanife Tuğçe Çağlar , Mustafa Buyukavci , Sevgi Pekcan

https://doi.org/10.70846/nigdetip.1541882

Öz

Ewing sarcoma is the second most common bone sarcoma worldwide. Distant metastases are common, with the most frequent site of metastasis being the lungs. The most important prognostic factor is the presence of metastatic disease at the time of diagnosis. The prognosis of Ewing sarcoma has recently improved with systemic chemotherapy and a multimodality approach. In this article, we present a case of Ewing sarcoma originating from the right 12th rib, diagnosed after pleural metastasis. Notably, surgical resection was not required because the mass disappeared completely in imaging studies performed after chemotherapy.

Anahtar Kelimeler

Child, Ewing Sarcoma, mass, pleural metastasis

Öksürük Şikayeti ile Gelip Ewing Sarkom Tanısı Alan Hasta

Öz

Ewing sarkomu, dünya çapında en sık görülen ikinci kemik sarkomudur. Tanı anında uzak metastazlara sık rastlanılır, en sık metastaz yeri akciğerlerdir ve en önemli prognostik faktör de tanı anındaki metastatik hastalığın varlığıdır. Ewing sarkomunun prognozu, sistemik kemoterapi ve multimodalite yaklaşımı ile son zamanlarda iyileşmiştir. Biz bu makalede sağ 12. kostadan köken almış ve plevra metastazı sonrası tanı almış olan, kemoterapi tedavisi sonrası yapılan görüntülemelerde kitle tamamen kaybolduğu için cerrahi rezeksiyona gerek duyulmayan bir Ewing Sarkomu olgusunu literatürde ender olarak görülmesi nedeniyle sunmak istedik.

Anahtar Kelimeler

Çocuk, Ewing Sarkom, kitle, plevral metastaz

Kaynakça

• Biswas B, Bakhshi S. Management of Ewing sarcoma family of tumors: Current scenario and unmet need. World J Orthop. 2016;7(9):527-38. doi:10.5312/wjo.v7.i9.527.
• Sasi A, Chitikela S, Ganguly S, Biswas B, Pushpam D, Kumar A, et al. Treatment outcomes in patients with Ewing sarcoma of the spine in a resource-challenged setting: 17-year experience from a single center in India. Pediatr Hematol Oncol. 2024;41(3):211-23. doi:10.1080/08880018.2023.2296949.
• Li T, Goldberg RA, Becker B, McCann J. Primary orbital extraskeletal Ewing sarcoma. Arch Ophthalmol. 2003;121(7):1049-52. doi:10.1001/archopht.121.7.1049.
• Haybaeck J, Roessner A. [Malignant round cell tumors: The Ewing sarcoma and beyond]. Pathologe. 2020 Mar;41(2):116-22. doi: 10.1007/s00292-020-00759-y
• Biswas B, Rastogi S, Khan SA, Shukla NK, Deo SV, Agarwala S, et al. Developing a prognostic model for localized Ewing sarcoma family of tumors: A single institutional experience of 224 cases treated with uniform chemotherapy protocol. J Surg Oncol. 2015;111(6):683-9. doi: 10.1002/jso.23861.
• Indelicato DJ, Keole SR, Lagmay JP, Morris CG, Gibbs CP, Scarborough MT, et al. Chest wall Ewing sarcoma family of tumors: long-term outcomes. Int J Radiat Oncol Biol Phys. 2011;81(1):158-66. doi: 10.1016/j.ijrobp.2010.04.066.
• Maheshwari AV, Cheng EY. Ewing sarcoma family of tumors. J Am Acad Orthop Surg. 2010 Feb;18(2):94-107. doi: 10.5435/00124635-201002000-00004.
• Kinsella TJ, Miser JS, Waller B, Venzon D, Glatstein E, Weaver-McClure L, et al. Long-term follow-up of Ewing's sarcoma of bone treated with combined modality therapy. Int J Radiat Oncol Biol Phys. 1991;20(3):389-95. doi: 10.1016/0360-3016(91)90047-8.
• Kutluk MT, Yalçin B, Akyüz C, Varan A, Büyükpamukçu M, et al. Treatment results and prognostic factors in Ewing sarcoma. Pediatr Hematol Oncol. 2004;21(7):597-610. doi: 10.1080/08880010490501006.
• Huang SH, Ko WS, Jen YM, Lee SC, Hwang WS, et al. Intrathoracic extraskeletal Ewing's sarcoma: a case report and review of literature. Zhonghua Yi Xue Za Zhi (Taipei). 1993;51(6):474-8. PMID: 8281497.
• Daugaard S, Kamby C, Sunde LM, Myhre-Jensen O, Schiødt T, et al. Ewing's sarcoma: A retrospective study of histological and immunohistochemical factors and their relation to prognosis. Virchows Arch A Pathol Anat Histopathol. 1989;414(3):243-51. doi: 10.1007/BF00822028.
• Allam K, Sze G. MR of primary extraosseous Ewing sarcoma. AJNR Am J Neuroradiol. 1994;15(2):305-7. PMID: 8192078.
• Koscielniak E, Harms D, Henze G, Jürgens H, Gadner H, Herbst M, et al. Results of treatment for soft tissue sarcoma in childhood and adolescence: a final report of the German Cooperative Soft Tissue Sarcoma Study CWS-86. J Clin Oncol. 1999;17(12):3706-19. doi: 10.1200/JCO.1999.17.12.3706.