Can Vitamin D Deficiency Predict Coronary Artery Disease?

Yıl 2018, Cilt: 6 Sayı: 2, 45 - 52, 12.09.2018

Şeref Alpsoy , Aydın Akyüz , Demet Özkaramanli Gür , Birol Topçu , Hasan Değirmenci

Öz

Anahtar Kelimeler

25-hydroxyvitamin D, Coronary artery disease, Hhigh-density lipoprotein cholesterol, C-reactive protein

Vitamin D Eksikliği Koroner Arter Hastalığı İçin Ön Görüdürücü Müdür?

Öz

Amaç: D vitamininin ve koroner
arter hastalığının (KAH) ilişkisiyle ilgili ortaya çıkan verilere dayanarak,
KAH'da D vitamini ile C-reaktif protein (CRP) ile temsil edilen inflamasyon ve
serum lipid profili arasında  ilişki
bulunup bulunmadığını araştırdık.

Materyal ve Metod: Yeni KAH tanısı  konmuş 115 hasta ve 62 sağlıklı birey
çalışmaya alındı. Kan lipidleri, CRP ve D vitamini düzeyleri ölçüldü ve hasta
ve kontrol gruplarının değerleri karşılaştırıldı.

Bulgular: Hasta grubunda düşük
dansiteli lipoprotein kolesterol (DDL-K), CRP ve trigliserit düzeyleri yüksek,
vitamin D ve yüksek dansiteli lipoprotein kolesterol (YDL-K) düşüktü.Vitamin D
ile YDL-K arasında pozitif korelasyon(r=0.328; p<0.001), vitamin D ile CRP arasında
negatif korelasyon (r=-0.484; p<0.001) vardı. Multivariate lojistik
regresyon analizinde, sigara (p=0.001,
OR = 5.301; 95% CI = 2.215 – 12.687), hipertansiyon varlığı (p=0.040, OR =
2.355; 95% CI=1.039 – 5.336), DDL-K düzeyi (p=0.048, OR =1.021, 95% CI=1.000 –
1.042) ve vitamin D düzeyi (p=0.001, OR = 0.937, 95% CI = 0.902 – 0.973) KAH
belirleyicisi olarak bulundular.

 

Sonuç: Azalmış D vitamini
seviyeleri, KAH'da düşük YDL-K ve yüksek CRP seviyeleri ile ilişkilidir.
Sigara, hipertansiyon, DDL-K ve D vitamini, KAH'ın belirleyicisidirler. 

Anahtar Kelimeler

25-hidroksi Vitamin D, Koroner arter hastalığı, Yüksek dansiteli lipoprotein kolesterol, C-reaktif protein

Kaynakça

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