Mean platelet volume to lymphocyte ratio: A novel marker for idiopathic sudden sensorineural hearing loss

Ceyhun Aksakal; Ahmet Mutlu

doi:10.37696/nkmj.656479

Araştırma Makalesi

Ortalama trombosit hacminin lenfosit sayısına oranı: İdiopatik ani sensörinöral işitme kaybında yeni bir belirteç

Yıl 2020, Cilt: 8 Sayı: 2, 163 - 169, 23.08.2020

Ceyhun Aksakal , Ahmet Mutlu

https://doi.org/10.37696/nkmj.656479

Öz

Objective: To investigate the value of mean platelet volume (MPV) to lymphocyte ratio (MPVLR), a novel marker, in determining the prognosis of sudden sensorineural hearing loss (SSNHL).
Material and Method: This retrospective cross-sectional study study included the patient group consisting of 65 SSNHL and the control group consisting of 50 healthy individuals. 65 patients with SSNHL were divided into two subgroups as 44 recovered patients and 21 unrecovered patients. The SSHNL patients and the control group, and the recovered SSNHL patients and the unrecovered SSNHL patients were compared statistically in terms of MPV, lymphocyte count and MPVLR.
Result(s): The mean MPV value was 9.28 ± 0.99 fL in the patients and 9.25 ±0.82 fL in the control group, and the difference was not statistically significant (p = 0,851). The mean lymphocyte count was 1.90 ± 1.02 in the study group and 2.55± 0.78 in the control group, and the difference was statistically significant (p <0.001). The mean MPVLR value was 6.44 ± 4.14 in the study group and 4.03 ± 1.62 in the control group and the difference was statistically significant (p<0,05).
Conclusion(s): MPVLR is an easily accessible marker and levels are increased by severity of the disease. The lymphocyte count is also declined according to the severity of the disease. These results showed that MPVLR and lymphocyte count can help to predict the SSNHL prognosis. With future studies, the value of MPVLR in the prognosis of SSNHL may be better understood.

Anahtar Kelimeler

mean platelet volume, mean platelet volume to lymphocyte ratio, sudden sensorineural hearing loss

Kaynakça

1. Alimoglu Y, Inci E, Edizer DT, Ozdilek A, Aslan M. Comparison of oral steroid, intratympanic steroid, hyperbaric oxygen and oral steroid + hyperbaric oxygen treatments in idiopathic sudden sensorineural hearing loss cases. Eur Arch Otorhinolaryngol 2011(12);268:1735–1741.
2. Prenzler NK, Schwab B, Kaplan DM , El-Saied S. The role of explorative tympanotomy in patients with sudden sensorineural hearing loss with and without perilymphatic fistula. Am J Otolaryngol. 2018(1); 39:46-49.
3. Durmuş K, Terzi H, Karatas TD, Doğan M, Uysal IÖ, Şencan M, et al. Assessment of Haematological factors involved in development and prognosis of idiopathic sudden sensorineural hearing loss, J. Craniofac Surg. 2016;27(1):85–91.
4. Bulgurcu S, Sahin B, Akgul G, Arslan İB, Çukurova İ. The Effects of Prognostic Factors in Idiopathic Sudden Hearing Loss. Int Arch Otorhinolaryngol. 2018;22(1):33-37.
5. Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis, J Thromb Haemost 2010;8(1):148-56.
6. Hudzik B, Szkodziński J, Lekston A, Gierlotka M, Poloński L, Gąsior M. Mean platelet volume-to-lymphocyte ratio: a novel marker of poor short- and long-term prognosis in patients with diabetes mellitus and acute myocardial infarction. J Diabetes Complications. 2016; 30(6):1097-1102.
7. Karli R, Alacam H, Unal R, Kucuk H, Aksoy A, Ayhan E et al. Mean platelet volume: is it a predictive parameter in the diagnosis of sudden sensorineural hearing loss? Indian J Otolaryngol Head Neck Surg. 2013;65(4):350-353.
8. Kocak HE, Elbistanlı MS, Acıpayam H, Alakras WME, Kıral MN, Kayhan FT. Are neutrophil/lymphocyte and platelet/lymphocyte ratios related with formation of sudden hearing loss and its prognosis? Eur Ann Otorhinolaryngol Head Neck Dis. 2017;134(6):383-386.
9. Siegel LG. The treatment of idiopathic sudden sensorineural hearing loss. Otolaryngol. Clin N. Am. 1975; 8(2): 467-473.
10. Masuda M, Kanzaki S, Minami S, Kikuchi J, Kanzaki J, Sato H, et al. Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol 2012; 33(7):1142–50.
11. Almosnino G, Holm JR, Schwartz SR, Zeitler DM. The Role of Hyperbaric Oxygen as Salvage Therapy for Sudden Sensorineural Hearing Loss. Ann Otol Rhinol Laryngol. 2018; 127(10):672-676.
12. Mosnier I, Stepanian A, Baron G, Bodenez C, Robier A, Meyer B, et al. Cardiovascular and thromboembolic risk factors in idiopathic sudden sensorineural hearing loss: a case---control study. Audiol Neurootol. 2011; 16(1):55-66.
13. Mutlu A, Cam I, Dasli S, Topdag M. Doppler ultrasonography can be useful to determine the etiology of idiopathic sudden sensorineural hearing loss. Auris Nasus Larynx. 2018; 45(3):456-460.
14. Kim JY, Hong JY, Kim DK. Association of Sudden Sensorineural Hearing Loss With Risk of Cardiocerebrovascular Disease: A Study Using Data From the Korea National Health Insurance Service. JAMA Otolaryngol Head Neck Surg. 2018;144(2):129-135.
15. Ullrich D, Aurbach G, Drobik C. A prospective study of hyperlipidemia as a pathogenic factor in sudden hearing loss. Eur Arch Otorhinolaryngol 1992; 249(5):273–276.
16. Ballesteros F, Alobid I, Tassies D, Reverter JC, Scharf RE, Guilemany JM, et al. Is there an overlap between sudden neurosensorial hearing loss and cardiovascular risk factors? Audiol Neurotol 2009;14(3):139–145.
17. Braekkan SK, Mathiesen EB, Njølstad I, Wilsgaard T, Størmer J, Hansen JB. Mean platelet volume is a risk factor for venous thromboembolism: the Tromso Study, Tromso, Norway. J Thromb Haemost 2010; 8(1):157-162.
18. Ulu S, Ulu MS, Ahsen A, Yucedag F, Aycicek A, Celik S. Increased levels of mean platelet volume: a possible relationship with idiopathic sudden hearing loss 2013; 270(11):2875-2878
19. Kurtul A, Acikgoz SK. Usefulness of Mean Platelet Volume-to-Lymphocyte Ratio for Predicting Angiographic No-Reflow and Short-Term Prognosis After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction. Am J Cardiol. 2017; 120(4):534-541.
20. Bittencourt AG, Santos AF, Goffi-Gomez MV, Kutscher K, Tsuji RK, Brito RD et al .Microangiopathy of the inner ear, deafness, and cochlear implantation in a patient with Susac syndrome. Acta Otolaryngol. 2011;131(10):1123-1128.
21. Lin RJ, Krall R, Westerberg BD, Chadha NK, Chau JK. Systematic review and meta-analysis of the risk factors for sudden sensorineural hearing loss in adults. Laryngoscope. 2012; 122(3):624-635.
22. Schulz S, Ritter J, Oertel K, Witt K, Bär KJ, Guntinas-Lichius O. Altered autonomic regulation as a cardiovascular risk marker for patients with sudden sensorineural hearing loss. Otol Neurotol. 2014;35(10):1720-1729.
23. Le Tulzo Y, Pangault C, Gacouin A, Guilloux V, Tribut O, Amiot L et al. Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome. Shock 2002; 18(6):487-494.
24. Kassner SS, Schottler S, Bonaterra GA, Stern-Sträter J, Sommer U, Hormann K et al. Proinflammatory and proadhesive activation of lymphocytes and macrophages in sudden sensorineural hearing loss. Audiol Neurootol 2011; 16(4):254–262.