Characterization of the Essential Oil and Anticandidal Evaluation of Thymus pallasicus Hayek & Velen. from Turkey

Yıl 2019, Cilt: 6 Sayı: 4, 1 - 5, 26.12.2019

Gülderen Yılmaz , Betül Demirci , Zeki Aytaç , Fatih Demirci

Öz

Thymus L. of the Lamiaceae with 220
ssp. is concentrated in the Mediterranean region. Thymus species are well known as “Kekik” in Turkish and are used as
herbal tea and spices, according to recent records, the genus is represented with
40 ssp. where 17 species are endemic to Turkey. 
The study material Thymus pallasicus is one of the endemic species
for Turkey, where the essential oil was obtained from the air dried aerial parts
by hydrodistillation subsequently analyzed by GC-FID and GC-MS, respectively. The
main component was identified as thymol (55.5 %) along with the monoterpenes
p-cymene (19.9 %), γ-terpinene (7.2%), carvacrol (5 %), and 1,8-cineole (%1.4).
The essential oil was also evaluated for its anticandidal activity against five
different standard human pathogenic strains, according to a modified in vitro
CSLI micro dilution method. The minimum inhibitory activity of the essential
oil was 250-500 microgram/mL against the tested Candida sp. suggesting rather weak inhibitory activity when
compared to the standard antifungal fluconazole (0.5-16 microgram/mL). As Thymus species are known for their
antimicrobial activities it is suggested that other clinical and pathogenic
strains should be further evaluated.

Anahtar Kelimeler

Thymus pallasicus, Lamiaceae, essential oil composition

Kaynakça

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