KARACİĞER NAKLİ ALICILARINDA LATENT Epstein-Barr VİRÜS VE SİTOMEGALOVİRÜS ENFEKSİYON PROFLAKSİSİ

Yıl 2019, Cilt: 14 Sayı: 2, 104 - 107, 16.04.2019

Gokhan Ertugrul , Mustafa Salih Akin

Öz

İmmünsüpresif
ilaçlar karaciğer nakli alıcısını latent Epstein Barr virüs (EBV) ve
sitomegalovirüs (CMV) enfeksiyonlarının
reaktivasyonuna yatkınlaştırır. Bu hastalara verilen profilaktik tedaviler,
reaktivasyonun önlenmesi için çok önemlidir. Bu çalışmanın amacı, karaciğer
nakli alıcılarında latent EBV ve CMV enfeksiyonlarının profilaksisini
değerlendirmektir. Bu çalışma retrospektiftir. Çalışmada karaciğer nakli
alıcılarının Nisan 2014–Nisan 2017 tarihleri arasında EBV DNA, CMV DNA ve
profilaktik tedavi sonuçları ile incelendi. 170 alıcı hastaya proflaktik tedavi
için Valgansiklovir verilmişti.
48 aylık takipte EBV ve CMV’nin herhangi bir reaktivasyonu tespit edilmedi. Valgansiklovir, karaciğer nakli alıcılarında latent EBV ve
CMV enfeksiyonunun profilaktik tedavisinde başarılı görünmektedir.

Anahtar Kelimeler

Karaciğer Nakli, Latent EBV Enfeksiyonu, CMV Enfeksiyonu, Proflaksi, İmmünsüpresif ilaçlar

Kaynakça

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