The clinical and prognostic value of the neutrophil lymphocyte ratio, the platelet lymphocyte ratio and mean platelet volume in tinnitus patients

Yıl 2021, Cilt: 38 Sayı: 3, 251 - 254, 01.05.2021

Ayşe Çeçen , Özgür Kemal , Uğur Yıldırım , Esra Kavaz , Özlem Terzi

Öz

Objectives: There are high number of studies about the relationship between inflammation and tinnitus. The aim of this study was to evaluate the prognostic importance of the use of the neutrophil-lymphocyte ratio (NLR), the platelet lymphocyte ratio (PLR), and the mean platelet volume (MPV) in patients with tinnitus.
Methodology: This prospective study included 74 patients and 65 healthy control group. The severity of the tinnitus was classified using the Tinnitus Handicap Index (THI). The neutrophil and lymphocyte counts, NLR, PLR and MPV values were recorded and compared between the groups.
Results: MPV, and MCV median values were determined statistically significantly higher in the patient group than in the control group (p:0.001, p:0.000). No statistically significant difference was determined between the groups in respect of the NLR and PLR (p>0.05). The mean THI score was calculated as 51.5±21.1 (range, 12.0- 90.0). No statistically significant correlations were determined between the THI and NLR and PLR (r:0.03, p:0.75, and r:0.04, p:0.70).
Conclusion: The MPV and MCV values were higher in tinnitus patients than in the control group. However, NLR and PLR were not determined to have any statistically significant relationship with tinnitus or the THI scores.

Anahtar Kelimeler

neutrophil-lymphocyte ratio,, tinnitus, platelet-lymphocyte ratio, mean platelet volume

Kaynakça

• References 1. Jonas T. SD, Byron J. Bailey's Head and Neck Surgery. Vol 5. USA: Lippincott Williams & Wilkins; 2013.
• 2. Kemal O, Muderris T, Basar F, Kutlar G, Gul F. Prognostic value of mean platelet volume on tinnitus. J Laryngol Otol. 2016;130(2):162-165.
• 3. Aydoğdu İ YG, Kumral TL, Saltürk Z , Aydoğdu Z, İnan M, Uyar Y. Ani İşitme Kaybı Olan Hastalarda Yeni Prognostik Parametreler: Nötrofil/Lenfosit Oranı ve Platelet/Lenfosit Oranı. Okmeydanı Tıp Dergisi 2017;33(1):1-5.
• 4. Sarikaya Y, Bayraktar C, Karatas M, et al. Increased mean platelet volume in patients with idiopathic subjective tinnitus. Eur Arch Otorhinolaryngol. 2016;273(11):3533-3536.
• 5. Ozbay I, Kahraman C, Balikci HH, et al. Neutrophil-to-lymphocyte ratio in patients with severe tinnitus: prospective, controlled clinical study. J Laryngol Otol. 2015;129(6):544-547.
• 6. Ulusoy B, Bozdemir K, Akyol M, Mise HI, Kutluhan A, Korkmaz MH. Investigation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and mean platelet volume in patients with tinnitus. J Laryngol Otol. 2018;132(2):129-132.
• 7. Kemal O KY, Atmaca S, Koyuncu M, Bel A, Yucel I, Unal R. The value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in salivary gland tumors. B-ENT. 2019;15(1):33-37.
• 8. Meikle MB, Henry JA, Griest SE, et al. The tinnitus functional index: development of a new clinical measure for chronic, intrusive tinnitus. Ear Hear. 2012;33(2):153-176.
• 9. Newman CW, Jacobson GP, Spitzer JB. Development of the Tinnitus Handicap Inventory. Arch Otolaryngol Head Neck Surg. 1996;122(2):143-148.
• 10. Egilmez OK, Kalcioglu MT, Kokten N. [Questionnaire methods used in the psychosomatic evaluation of tinnitus]. Kulak Burun Bogaz Ihtis Derg. 2014;24(5):303-310.
• 11. Zahorec R. Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102(1):5-14.
• 12. Seo YJ, Jeong JH, Choi JY, Moon IS. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss. Dis Markers. 2014;2014:702807.
• 13. Yersal O, Odabasi E, Ozdemir O, Kemal Y. Prognostic significance of pre-treatment neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with glioblastoma. Mol Clin Oncol. 2018;9(4):453-458.
• 14. Bayram A YM, Doğan M, Güneri E, Özcan I. Assessment of neutrophil-to lymphocyte ratio, platelet-to lymphocyte ratio and mean platelet volume in patients with tinnitus. ENT Updates 2015:103-106.
• 15. Bucak A, Ulu S, Oruc S, et al. Neutrophil-to-lymphocyte ratio as a novel-potential marker for predicting prognosis of Bell palsy. Laryngoscope. 2014;124(7):1678-1681.
• 16. Ulu S, Ulu MS, Ahsen A, Yucedag F, Aycicek A, Celik S. Increased levels of mean platelet volume: a possible relationship with idiopathic sudden hearing loss. Eur Arch Otorhinolaryngol. 2013;270(11):2875-2878.
• 17. Karli R, Alacam H, Unal R, Kucuk H, Aksoy A, Ayhan E. Mean platelet volume: is it a predictive parameter in the diagnosis of sudden sensorineural hearing loss? Indian J Otolaryngol Head Neck Surg. 2013;65(4):350-353. 18. Blaha M, Kostal M, Drsata J, Chrobok V, Lanska M, Zak P. Does mean platelet volume really increase in sudden sensorial hearing loss? Eur Arch Otorhinolaryngol. 2015;272(9):2575-2578.