SCUBE-1 as a novel predictor of thromboembolic event

Year 2023, Volume: 40 Issue: 1, 197 - 198, 18.03.2023

Hatice Şeyma Akça

Abstract

SCUBE-1 is a newly identified, secreted cell surface protein that is determined during early embryogenesis. This protein consists of cascading EGF-like repeats following the N-terminal signal peptide sequence, a spacer region, cysteine-rich repeat motifs, and a CUB domain at the C-terminus. These molecules are stored in alpha granules in inactivated platelets, translocated to the platelet surface after activation by thrombin, secreted as small soluble fragments, and incorporated into the thrombus.

Keywords

SCUBE-1, thromboembolic events, myocardial infarction