Karbonmonoksit zehirlenmesi

Yıl 2017, Cilt: 9 Sayı: 4, 203 - 206, 07.12.2017

Serkan Tursun , Ayşegül Alpcan , Cihat Şanlı Mehmet Kabalcı

https://doi.org/10.21601/ortadogutipdergisi.361864

Öz

Karbon
monoksit, tatsız, kokusuz ve renklendirici zehirli bir gazdır ve zehirlenmeye
bağlı ölümlerin sebeplerinden biridir . Karbondioksit nedeniyle Amerika’da yılda
yaklaşık 45000 kişi etkilenmektedir. 
Yaygın kullanılan tedavisi normobarik ve hiperbarik oksijen tedavisidir.
Antidotu yoktur. Ayrıca hiperbarik oksijen tedavisi devam eden nörolojik
bulguları azaltmada da faydalıdır

Anahtar Kelimeler

Karbonmonoksit, zehirlenme

Carbonmonoxide poisoning

Öz

Carbon
monoxide, also known as silent killer because it is a tasteless, odorless and
colorless toxic gas, is the most common cause of fatal poisonings. It
is a serious threat to our country as it is in the whole world. In the United
States, 4 out of 45,000 / 500 million people affected by carbon monoxide
poisoning each year die, but this is not clear in our country. There is no
specific antidote. The most common treatment method is normobaric and
hyperbaric oxygen therapy. Hyperbaric oxygen therapy also contributes to the
reduction of neurological findings.

Anahtar Kelimeler

Carbon monoxide, poisoning

Kaynakça

• Huzar TF, George T, Cross JM. Carbon monoxide and cyanide toxicity: etiology, pathophysiology and treatment in inhalation injury. Expert Rev Respir Med 2013; 7:159-170.
• Chavouzis N, Pneumatikos I . Carbon monoxide inhalation poisoning. Pneumon 2014;27(1):16.
• Roughton FJW, Darling RC. The effect of carbon monoxide on oxyhemoglobin dissociation curve. Am J Physiol 1944; 141:17-31.
• Kao LW, Nanagas KA. Toxicity associated with carbon monoxide. Clin Lab Med 2006; 26:99-125.
• Hardy KR, Thom SR. Pathophysiology and treatment of carbon monoxide poisoning. J Toxicol Clin Toxicol 1994; 32:613-629.
• Gozubuyuk AA, Dag H, Kacar A, Karakurt Y, Arica V. Epidemiology, pathophysiology, clinical evaluation, and treatment of carbon monoxide poisoningin child, infant, and fetüs North Clin Istanb. 2017 May 10;4(1):100-107.
• Prockop LD, Chichkova RI. Carbon monoxide intoxication: an updated review. J Neurol Sci 2007; 262:122-130. Ernst A, Zibrak JD. Carbon monoxide poisoning. N Engl J Med. 1998;339:1603–8
• Rucker J & Fisher JA (2006). Carbon monoxide poisoning. In Clinical Critical Care Medicine, ed. Albert RK, Slutsky AS, Ranieri M, Takala J & Torres A, pp. 679–683. Mosby, Philadelphia , PA , USA .
• Weaver LK, Hopkins RO, Chan KJ, Churchill S, Elliott CG, Clemmer TP, et al. Hyperbaric oxygen for acute carbon monoxide poisoning. N Engl J Med. 2002;347:1057–67
• HL Yılmaz. Karbon monoksit zehirlenmesi. cat.cu.edu.tr Erişim tarihi aralık 2017
• Gorman DF, Clayton D, Gilligan JE, Webb RK: A longitudinal study of 100 consecutive admissions for carbon monoxide poisoning to the Royal Adelaide Hospital. Anesth Intens Care 20:311, 1992
• Weaver LK. Clinical practice: carbon monoxide poisoning. N Eng J Med 2009; 369:1217-1225.
• Weaver LK, Valentine KJ, Hopkins RO. Carbon monoxide poisoning: risk factors for cognitive sequelae and the role of hyperbaric oxygen. Am J Respir Crit Care Med 2007; 176:491-497.
• Hampson NB, Piantadosi CA, Thom SR, Weaver LK. Practice recommendations in the diagnosis, management, and prevention of carbon monoxide poisoning. Am J Respir Crit Care Med 2012; 186:1095-1101.
• Thom SR. Dehydrogenase conversion to oxidase and lipid peroxidation in brain after carbon monoxide poisoning. J Appl Physiol 1992; 73:1584-1589.