Comparison of levetiracetam or zonicamide additional treatments in partial epilepsy diseases which karbamazepine monotherapy is not responded

Yıl 2018, Cilt: 10 Sayı: 4, 511 - 515, 01.12.2018

Türkan Acar , Mehmet Fevzi Öztekin Neşe Öztekin

https://doi.org/10.21601/ortadogutipdergisi.365144

Öz

Background and Aims: Partial epilepsy is the most common
type of seizure and in some patients sufficient seizure control may not be
achieved despite monotherapy and even polytherapy. Our aim in this study was to
compare the efficacy and side effects of levetiracetam or zonisamide add-on
treatments in patients without seizure control with carbamazepine monotherapy.

Material and Method: Thirty-two patients aged 18-54 years
who were followed for at least 1 year by carbamazepine monotherapy were
included in the study. Zonisamide was added to 16 of these patients, and
levetiracetam was added to 16 of these patients. Patients were monitored for 3
months to be held at constant titration after the insertion therapy.

Results: The mean age of the group to which zonisamide was added was
33.4 ± 10.6 (7 males, 9 females) while the levetiracetam group had 35.7 ± 11.5
(8 males, 8 females). When 3-month follow-up period was evaluated in terms of
total number of seizures, there was no statistically significant difference
between the two groups in terms of efficacy and side effects (p = 0,377).

Conclusion: Levetiracetam or zonisamide can be used in patients
with partial seizures with similar side effects and fewer side effects in
patients with seizure control.

Anahtar Kelimeler

Levetiracetam, zonisamide, partial epilepsy

Karbamazepin monoterapisine yanıt alınamayan parsiyel epilepsi hastalarında levetiracetam veya zonisamid ek tedavilerinin karşılaştırılması

Öz

Giriş ve Amaç: Parsiyel epilepsi en sık görülen nöbet tipi olup bazı hastalarda
monoterapi ve hatta politerapiye rağmen yeterli nöbet kontrolü
sağlanamayabilir. Bu çalışmadaki amacımız karbamazepin monoterapisi ile nöbet
kontrolü sağlanamamış hastalarda levetirasetam veya zonisamid ekleme
tedavilerinin etkinlik ve yan etki bakımından karşılaştırılması hedeflenmiştir.

Gereç ve Yöntem: 18-54 yaş arası, en az 1 yıldır karbamazepin
monoterapisi ile takip edilen 32 hasta çalışmaya alındı. Bu hastaların 16’sına
zonisamid, 16’sına levetirasetam eklendi. Hastalar ekleme tedavisi sonrası
sabit titrasyonda tutulacak şekilde 3 ay boyunca izlendi.

Bulgular: Zonisamid eklenen grubun yaş ortalaması 33,4±10,6 (7
erkek, 9 kadın)
iken levetirasetam grubunda 35,7±11,5 (8 erkek, 8 kadın) idi. Toplam nöbet
sayıları bakımından 3 aylık izlem süresi değerlendirildiğinde her iki grup arasında
etkinlik ve yan etki bakımından istatistiksel olarak anlamlı fark
saptanmamıştır (p=0,377).

Sonuç: Parsiyel nöbetlerin ekleme tedavilerinde levetirasetam veya zonisamid
benzer oranda etkin olup nöbet kontrolü sağlanamayan hastalarda yan etki profilinin
de az olması nedeniyle kullanılabilir.

Anahtar Kelimeler

Levetirasetam, zonisamid, parsiyel epilepsi

Kaynakça

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