Antrasiklin ve taksan rezistant metastatik meme kanseri tedavisinde eribulin mesilat etkinlik ve tolerabilitesi. Tek merkez deneyimi.

Yıl 2019, Cilt: 11 Sayı: 1, 10 - 14, 31.03.2019

Çağlayan Geredeli

https://doi.org/10.21601/ortadogutipdergisi.409706

Öz

Amaç: Mikrotübül
inhibitörü olan eribulin mesilat antrasiklin ve taksana rezistant metastatik
meme kanserli hastalarda kullanımı kabul edilmiştir. Amaç eribulin mesilatın
etkinliğini araştırmak.
Gereç ve Yöntemler: Retrospektif
çalışmada İstanbul Okmeydanı eğitim ve araştırma hastanesi tıbbi onkoloji
kliniğinde metastatik meme kanseri nedeniyle tedavi görmekte olan ve öncesinde
antrasiklin ve taksan dahil olmak üzere en az 2 seri kemoterapi almış olan
hastalar alındı.
Bulgular: Çalışmaya toplam 25 hasta
alındı. Median yaş 54,9 (range 36-73) idi. median takip süresi 11.6 aydı.
Hastaların %68 ER pozitif, %68 Pr pozitif, %8,3 HER2 pozitif ve %6,2 triple
negatifti. Hastalardan %78 inde karaciğer, %64 ünde kemik,%36sında akciğer
metastazı mevcuttu. Eribuli seri sayısı 4,4 (min3-max6) idi. Eribulin kür
sayısı 6,6 (min 1-max 33) idi. Median PFS 6,6 (0-26) ay olup median OS 17
(0-30) aydı. %8 inde tam yanıt (2 hasta), %12 (3hasta) sinde parsiyel yanıt,%52
(13 hasta) stabil yanıt ve %28 (7 hasta ) progresif hastalık mevcuttu. Hastaların
hormon reseptör durumu ve HER2 durumuna göre sağ kalımda farklılık yoktu(P=0,187).
Hastalardaki metastaz bölgelerine göre de sağ kalım da farklılık tespit
edilmedi(P=0,875). %12 (3 hasta ) hastada grade 3-4 hematolojik toksisite ve
%4( 1 hasta )hastada grade 3-4 nöropati görülmüşken %40 (10 hasta ) hastada
grade 1-2 hematolojik toksisite, %24 (6hasta ) hastada grade 1-2 nöropati
görülmüştür.
Sonuç: Eribulin mesilat antrasiklin
ve taksan rezistans önceden çoklu seri kemoterapi almış metastatik meme kanserli
hastaların tedavisinde 3. Seri ve daha sonraki serilerde etkin ve tolerabl
bulunmuştur.

Anahtar Kelimeler

metastatik meme kanseri, kemoterapi, eribulin mesilat

Efficacy and tolerability of eribulin mesylate in the treatment of anthracycline and taksan resistance to metastatic breast cancer. Single central experience

Öz

Aim: The
microtubule inhibitor eribulin mesylate anthracycline and taxane resistance
have been accepted for use in patients with metastatic breast cancer. The goal
is to investigate the efficacy of eribulin mesylate.

Material
and Methods: Retrospective study was carried out in Istanbul
Okmeydanı educational and research hospital medical oncology clinic patients
who were treated for metastatic breast cancer and who had received at least 2
serial chemotherapy including anthracycline and taksan.
Results: A total of 25 patients were
included in the study. Median age was 54.9 (range 36-73). Median follow-up time
is 11.6 months. 68% of the patients were ER positive, 68% were Pr positive,
8.3% were HER2 positive and 6.2% were triple negative. 78% of the patients had
liver, 64% had bone, and 36% had lung metastases. The treatement line number
was 4.4 (min3-max6). The number of cycles of Eribulin was 6.6 (min 1-max 33).
Median PFS is 6.6 (0-26) months and median OS is 17 (0-30). There were 8%
complete response (2 patients), 12% (3 patients) partial response, 52% (13
patients) stable response and 28% (7 patients) progressive disease. there was no
difference in survival according to patients' hormone receptor status and HER2
status (P = 0.187). There was no difference in survival according to the
metastatic sites in the patients (P = 0.875). Grade 3 to 4 hematologic toxicity
in 12% (3 patients) and grade 3-4 neuropathy in 4% (1 patient) in the
patient,40% (10 patients) grade 1-2 hematologic toxicity in the patient, grade 1-2
neuropathies were seen
 Conclusion: Eribulin mesylate have been
found to be effective and tolerable in line 3 and more than subsequent line in
the treatment of patients with metastatic breast cancer who anthracycline and
taksan resistance and previously received multiple line chemotherapy.

Anahtar Kelimeler

metastatic breast cancer, chemotherapy, eribulin mesylate

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