Kan Grubu Farklılıkları Larinks Kanseri Gelişiminde Belirleyici Bir Faktör Olabilir Mi?

Yıl 2022, Cilt: 44 Sayı: 2, 204 - 210, 28.02.2022

Hasan Çanakcı

https://doi.org/10.20515/otd.951140

Öz

Literatürde larinks kanseri ve kan grupları arasındaki ilişkinin araştırıldığı çalışmalarda tartışmalı sonuçlar mevcuttur. Çalışmamızın amacı kan grubu farklılıkları ve larinks kanser gelişim evreleri arasındaki olası ilişkinin incelenmesidir. Çalışmamıza 3. Basamak bir sağlık kuruluşunda Kulak Burun Boğaz Hastalıkları ve Baş Boyun Cerrahisi Kliniği’nde 01 Ocak 2014- 31 Ekim 2020 yılları arasında, larinks patolojisi ön tanısı ile direkt laringoskopi altında biyopsi operasyonu geçirmiş olan 251 hastanın dosyaları geriye dönük olarak incelenmiştir. Hastaların yaş, cinsiyet, kan grubu verileri ve histopatolojik tanıları değerlendirilmiştir. Hastalar histopatolojik tanılarına göre % 32,65 oranında benign (n:64), %38,78 oranında premalign (n:76) ve %28,57 oranında malign (n:56) laringeal lezyon olarak gruplandırılmıştır. Gruplar yaş açısından karşılaştırıldığında yaş ortalaması malign laringeal lezyon grubunda premalign laringeal lezyon grubundan, premalign laringeal lezyon grubunda da benign laringeal lezyon grubundan anlamlı şekilde yüksektir (p<0,001). Cinsiyet dağılımına bakıldığında erkek cinsiyet oranı malign laringeal lezyon grubunda premalign laringeal lezyon grubundan, premalign lezyon grubunda da benign laringeal lezyon grubundan anlamlı şekilde yüksektir (p<0,001). Gruplar arasında kan grupları açısından kıyaslama yapıldığında A kan grubu taşıyan hasta oranı malign laringeal lezyon ve premalign laringeal lezyon gruplarında benign laringeal lezyon grubuna göre anlamlı bir şekilde yüksek bulunmuştur (sırasıyla p=0,005, p=0,025). Diğer kan grupları dağılımında istatistiksel açsından anlamlı bir fark saptanmamıştır. Bu bulgularla larinks kanseri gelişimi sürecinde ya da tanılı hastaların takiplerinde A kan grubuna sahip bireylerin malignleşme potansiyellerinin daha fazla olabilme ihtimali sebebiyle yakın takip edilmesinin faydalı olacağını düşünmekteyiz.

Anahtar Kelimeler

Larinks kanseri, Kan grubu, Displazi, Risk faktörü

Destekleyen Kurum

Destekleyen kurum bulunmamaktadır.

Can Abo Blood Groupıng Be A Rısk Factor For Laryngeal Cancer?

Öz

There are controversial results in studies investigating the relationship between laryngeal cancer and blood group in the literature. The aim of our study is to examine the possible relationship between blood group and laryngeal cancer. 251 cases who had undergone direct laryngoscopy and biopsy with the diagnosis of laryngeal pathology, in the Department of Otorhinolaryngology and Head and Neck Surgery of a 3rd level healthcare institution in the period between January 01,2014 and October 31,2020 were analyzed. The age, gender, blood group and histopathological diagnosis of the cases were evaluated. According to their histopathological diagnosis, the cases were grouped as benign (32,65%, n:64), premalignant (38.78%, n:76) and malignant laryngeal lesion (28.57%, n:56). When the groups were compared in terms of age, the mean age was significantly higher in the malignant laryngeal lesion group than in the premalignant group and in the premalignant laryngeal lesion group than in the benign group (p<0.001). Considering the gender distribution, male sex ratio was significantly higher in the malignant laryngeal lesion group than in the premalignant group, and in the premalignant lesion group compared to the benign group (p<0.001). When the blood groups were compared between the groups, the rate of te cases with blood group A was found to be significantly higher in the malignant laryngeal lesion and premalignant laryngeal lesion groups compared to the benign laryngeal lesion group (p=0.005, p=0.025, respectively). No statistically significant difference was found in the distribution of other blood groups. As a result, we think that the close follow up of the cases diagnosed premalign laryngeal lesions or laryngeal cancer with blood group A would be useful because of the high potential of the canserization of the cases wth the blood group A suffer from the laryngeal lesions.

Anahtar Kelimeler

Larynx cancer; blood group; dysplasia; risc factors.

Kaynakça

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