Prematüre Retinopatisi ile Serum İnsülin Benzeri Büyüme Faktörü-1 Düzeyleri Arasındaki İlişki

Yıl 2008, Cilt: 6 Sayı: 3, 47 - 52, 01.12.2008

Merih Çetinkaya , Nilgün Köksal Hilal Özkan Ahmet Tuncer Özmen

Öz

Amaç: Bu çalışmanın amacı serum insülin benzeri büyüme faktörü-I IGF-I ileprematüre retinopatisi ROP arasında ilişki olup olmadığının belirlenmesidir. Gereç ve Yöntem: Bu prospektif çalışmaya Kasım 2006 ile Mayıs 2007 arasında 34gestasyonel haftadan küçük olarak doğan toplam 33 bebek dahil edildi. Prematüre retinopatisi ROP , uluslararası ROP sınıflandırmasına göre sınıflandırıldı. SerumIGF-I düzeyleri doğumdan hemen sonra çalışılmaya başlandı ve olgular taburcuedilene kadar haftalık olarak çalışılmaya devam edildi. Bulgular: Çalışmaya alınan 33 bebekten %36’sında ROP saptandı. Düşük doğumağırlığı ve daha küçük gestasyonel yaş daha yüksek ROP gelişimi oranı ile ilişkiliidi. ROP grubundaki ortalama serum IGF-1 düzeylerinin ROP olmayan gruba göreistatistiksel olarak anlamlı düşük olduğu bulundu p=0,03 . Haftalık ölçülen serumIGF-1 düzeyleri ile ROP gelişimi arasında ise istatistiksel olarak anlamlı ilişki saptanmadı p>0,05 . Tartışma: Sonuç olarak, preterm bebeklerdeki düşük ortalama IGF-1 düzeyleriROP gelişimi oranı ile ilişkili bulunmuştur

Anahtar Kelimeler

Prematüre retinopatisi, insülin benzeri büyüme faktörü-1, prematürite

The Relationship Between Serum Insulin-Like Growth Factor-1 Levels and Retinopathy of Prematurity

Öz

Aim: The aim of this study was to investigate the association between serum insulin like growth factor I IGF-I and retinopathy of prematurity ROP . Materials and Method: We prospectively studied the newborn infants born at apostmenstrual age of

Anahtar Kelimeler

Retinopathy of prematurity, insülin like growth factor 1, prematurity

Kaynakça

• 1. Wheatley CM, Dickinson JL, Mackey DA, Craig JE, Sale MM. Retinopathy of prematurity: recent advances in our understanding. Archives of Disease in Childhood Fetal and Neonatal Edition 2002; 87: 78-82.
• 2. Terry TL. Extreme prematurty and fibroblastic overgrowth of persistant vascular sheat behind each crystalline lens. Am J Ophtalmol 1942; 25: 203-4.
• 3. Smith LE. Pathogenesis of retinopathy of prematurity. Growth Horm IGF Res 2004; 14: 140-4.
• 4. Cryotherapy for Retinopathy of Prematurity Cooperative Group. Multicenter trial of retinopathy of prematurity: Preliminary results. Arch Opthalmol 1988; 106: 471-9.
• 5. Karkhaneh R, Mousavi SZ, Riazi-Esfahani M, et al. Incidence and risk factors of retinopathy of prematurity in a tertiary eye hospital in Tehran. Br J Ophthalmol 2008; 26: 10-5.
• 6. Phelps DL. Retinopathy of Prematurity: History, Classification, and Pathophysiology Neo Reviews 2001; 2: 153-66.
• 7. Friling R, Axer-Siegel R, Hersocovici Z, Weinberger D, Sirota L, Snir M. Retinopathy of prematurity in assisted versus natural conception and singleton versus multiple births. Ophthalmology 2007; 114: 321-4.
• 8. Niwald A, Piotrowski A, Gralek M. Analysis of some of the possible neonatal risk factors of development of retinopathy of prematurity. Klin Oczna 2008; 110: 31-4.
• 9. Hunter DJ, Mukai S, Hirose T. Advanced retinopathy of prematurity. In: Albert DM, Jacobiec FA (eds). Principles and Practice of Ophthalmology. Philadelphia: WB Saunders; 1994: 782-91.
• 10. Ashton N, Ward B, Serpell G. Effect of oxygen on developing retinal vessels with particular reference to the problem of retrolental fibroplasia. Br J Ophthalmol 1954; 38: 397-432.
• 11. Pau H. Retinopathy of prematurity: clinic and pathogenesis. Disproportion between apoptosis of vitreal and proliferation of retinal vascularization. Ophthalmologica 2008; 222: 220-4.
• 12. Smith LE, Wesolowski E, McLellan A, Kostyk SK, D'Amato R, Sullivan R, D'Amore PA. Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci 1994; 35: 101-11.
• 13. Penn JS, Tolman BL, Henry MM. Oxygen-induced retinopathy in the rat: relationship of retinal nonperfusion to subsequent neovascularization. Invest Ophthalmol Vis Sci 1994; 35: 3429-35.
• 14. McLeod DS, Crone SN, Lutty GA. Vasoproliferation in the neonatal dog model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci 1996; 37: 1322-33.
• 15. Aiello LP, Pierce EA, Foley ED, et al. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci 1995; 92: 10457-61.
• 16. Robinson GS, Pierce EA, Rook SL, Foley E, Webb R, Smith LE. Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy. Proc Natl Acad Sci 1996; 93: 4851-6.
• 17. Pierce EA, Foley ED, Smith LE. Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity. Arch Ophthalmol 1996; 114: 1219-28.
• 18. Kwinta P, Bik-Multanowski M, Mitkowska Z, Tomasik T, Pietrzyk JJ The clinical role of vascular endothelial growth factor (VEGF) system in the pathogenesis of retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol 2008; 246: 1467-75.
• 19. Ozaki H, Seo MS, Ozaki K, et al. Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization. Am J Pathol 2000; 156: 697-707.
• 20. Bennett A, Wilson DM, Liu F, Nagashima R, Rosenfeld RG, Hintz RL. Levels of insulin-like growth factors I and II in human cord blood. J Clin Endocrinol Metab 1983; 57: 609-12.
• 21. Giudice LC, de Zegher F, Gargosky SE, et al. Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth. J Clin Endocrinol Metab 1995; 80: 1548-55.
• 22. Lineham JD, Smith RM, Dahlenburg GW, King RA, Haslam RR, Stuart MC, Faull L. Circulating insulin-like growth factor I levels in newborn premature and full-term infants followed longitudinally. Early Hum Dev 1986; 13: 37-46.
• 23. Smith WJ, Underwood LE, Keyes L, Clemmons DR. Use of insulin-like growth factor I (IGF-I) and IGF-binding protein measurements to monitor feeding of premature infants. J Clin Endocrinol Metab 1997; 82: 3982-8.
• 24. Bona G, Aquili C, Ravanini P, et al. Growth hormone, insulin-like growth factor-I and somatostatin in human fetus, newborn, mother plasma and amniotic fluid. Panminerva Med 1994; 36: 5-12.
• 25. Hellstrom A, Engstrom E, Hard AL, et al. Postnatal serum insulin-like growth factor I deficiency is associated with retinopathy of prematurity and other complications of premature birth. Pediatrics 2003; 112: 1016-20.
• 26. Shennan AT, Dunn MS, Ohlsson A, Lennox K, Hoskins EM. Abnormal pulmonary outcomes in premature infants: predictions from oxygen requirement in the neonatal period. Pediatrics 1988; 82: 527-32.
• 27. Burstein J, Papile LA, Burstein R. Intraventricular hemorrhage and hydrocephalus in premature newborns: a prospective study with CT. AJR Am J Roentgenol 1979;132:631-5.
• 28. Hellstrom A, Perruzzi C, Ju M, et al. Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity. Proc Natl Acad Sci 2001; 98: 5804-8.
• 29. Hikino S, Ihara K, Yamamoto J, et al. Physical growth and retinopathy in preterm infants: involvement of IGF-I and GH. Pediatr Res 2001; 50: 732-6.
• 30. D’Amore PA. Mechanisms of retinal and choroidal neovascularization. Invest Ophthalmol Vis Sci 1994; 35: 3974-9.
• 31. Kwak N, Okamoto N, Wood JM, Campochiaro PA. VEGF is major stimulator in model of choroidal neovascularization. Invest Ophthalmol Vis Sci 2000; 41: 3158-64.
• 32. Kliffen M, Sharma HS, Mooy CM, Kerkvliet S, de Jong PT. Increased expression of angiogenic growth factors in age-related maculopathy. Br J Ophthalmol 1997; 81: 154-62.
• 33. King GL, Goodman AD, Buzney S, Moses A, Kahn CR. Receptors and growth –promiting effects of insulin and insulin-like growth factors on cells from bovine retinal capillaries and aorta. J Clin Invest 1985; 75: 1028-36.
• 34. Englert JA, Saunders RA, Purohit D, Hulsey TC, Ebeling M. The effect of anemia on retinopathy of prematurity in extremely low birth weight infants. J Perinatol 2001; 21: 21-6.
• 35. Brooks SE, Marcus DM, Gillis D, Pirie E, Johnson MH, Bhatia J. The effect of blood transfusion protocol on retinopathy of prematurity: Aprospectve randomized study. Pediatrics 2000; 106: 379-80.
• 36. Watts P, Adams GG, Thomas RM, Bunce C. Intraventricular haemorrhage and stage 3 retinopathy of prematurity. Br J Ophthalmol 2000; 84: 596-9.
• 37. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 1978; 92: 529-34.
• 38. Hungerford J, Stewart A, Hope P. Ocular sequelae of preterm birth and their relation to ultrasound evidence of cerebral damage. Br J Ophthalmol 1986; 70: 463-8.
• 39. Procianoy RS, Garcia-Prats JA, Hittner HM, Adams JM, Rudolph AJ. An association between retinopathy of prematurity and intraventricular hemorrhage in very low birth weight infants. Acta Paediatr Scand 1981; 70: 473-7.
• 40. Brown DR, Biglan AW, Stretavsky MM. Retinopathy of prematurity: the relationship with intraventricular hemorrhage and bronchopulmonary dysplasia. J Pediatr Ophthalmol Strabismus 1990; 27: 268-71