Nötrofil/Lenfosit Oranı, RDW, RPR, MPV ve MPR Hemogram İndekslerinin Febril Nöbet Tanısına Katkısı

Yıl 2020, Cilt: 18 Sayı: 3, 346 - 357, 18.12.2020

Turgay Çokyaman , Tolga Kasap

Öz

GİRİŞ ve AMAÇ: Bu çalışmada nötrofil/lenfosit oranı (NLR), kırmızı kan hücresi dağılım genişliği (RDW), RPR, MPR, ortalama trombosit hacmi (MPV), trombosit sayısı (PLT) gibi hemogram indekslerinin febril nöbet (FS) tanısına katkısının ayrıntılı olarak araştırılması amaçlandı.

YÖNTEM ve GEREÇLER: Çalışmaya 91 FS, 116 ateşli hastalık ve 100 sağlıklı kontrol olgusu dahil edildi. Yerine göre uygun istatistiksel analizlerle ikili ve üçlü grup karşılaştırmaları sonucu FS lehine anlamlı hemogram indeksleri tespit edildi ve ROC eğrisi analizine göre FS tanısı için tanı koydurucu sınır değerleri, duyarlılık ve özgüllükleri hesaplandı.

BULGULAR: NLR indeks FK grubunda anlamlı düzeyde yüksekti. FK grubunda median 2,6, ateşli hastalık ve sağlıklı kontrol grubunda sırasıyla 1,6 ve 0,7 bulundu (p<0,001). ROC eğrisi analizinde FK tanısı için NLR indeksinin sınır değerleri, duyarlılık ve özgüllükleri belirlendi. 1/RPR indeksi FK vakalarında istatistiksel olarak anlamlı düzeyde düşük bulundu. FK grubunda 20,5, ateşli hastalık ve sağlıklı kontrol gruplarında sırasıyla 23,3 ve 23,2 bulundu (p=0,003). NLR’ye benzer şekilde RPR indeks içinde ROC eğrisi analizinde FK tanısı için sınır değerleri, duyarlılık ve özgüllükleri hesaplandı.

TARTIŞMA ve SONUÇ: NLR ve 1/RPR indeksleri, FS tanısına katkıda bulunabilecek ucuz ve kolay erişilebilir hemogram parametreleridir. Acil servislerde ve ayaktan tedavi kliniklerinde pratisyen hekim ve pedyiatristler tarafından kolayca kullanılabilirler.

Anahtar Kelimeler

febril nöbet,, hemogram,, çocuk

Contribution of Neutrophil/Lymphocyte Ratio, RDW, RPR, MPV and MPR Indexes to Febrile Seizure Diagnosis

Öz

INTRODUCTION: In this study, it was aimed to investigate in detail the contribution of hemogram indices such as neutrophil/lymphocyteratio (NLR), red blood cell distribution width (RDW), RPR, MPR, mean platelet volume (MPV), and platelet count (PLT) to the diagnosis of febrile seizure (FS).

MATERIALS and METHODS: 91 FS, 116 febrile disease and 100 healthy control cases were included in the study. Significant hemogram indices in favor of FS were determined as a result of double and triple group comparisons with appropriate statistical analyzes, and diagnostic cut-off values, sensitivity and specificity were calculated for FS diagnosis according to receiever operating characteristic (ROC) curve analysis.

RESULTS: NLR index was significantly higher in the FS group. The median was 2.6 in the FS group, 1.6 and 0.7 in the febrile disease and healthy control groups, respectively (p<0.001). In the ROC curve analysis, thecut-off values, sensitivity and specificities of the NLR index for FS diagnosis were determined. The 1/RPR index was found to be statistically significantly lower in FS group. It was found to be 20.5 in the FS group, 23.3 and 23.2 in the febrile disease and healthy control groups, respectively (p=0.003). Similar to the NLR, cut-off values, sensitivity and specificities were calculated for FS diagnosis in the ROC curve analysis within the 1/RPR index.

CONCLUSIONS: NLR and 1/RPR indexes are cheap and easily accessible hemogram parameters that can contribute to the diagnosis of FS. They can be used simply by practitioners and pediatricians in emergency rooms and out patient clinics

Anahtar Kelimeler

febrile seizure,, hemogram,, children

Kaynakça

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