PROBIOTICS’ EFFECT ON NUTRITIONAL STATUS, APPETITE HORMONES, AND INFLAMMATION IN PRE-OBESE WOMEN

Yıl 2024, , 73 - 80, 04.06.2024

İzzet Ülker , Hilal Yıldıran , Mujde Akturk

https://doi.org/10.26650/JARHS2024-1347787

Öz

Objective: Obesity is one of the most common health problems in the world. The following methods are currently used to treat obesity: medical nutrition therapy, behavioral therapy, medical treatment, and surgical therapy. Discussions are still ongoing regarding whether changing the plasma levels of the hormones that regulate satiety and appetite can be used as a new add-on therapy to pre-existing obesity treatments to decrease food consumption. One possibility for changing the levels of the hormones that control hunger and satiety involves the use of probiotics. This study has been planned and conducted to examine the effects of probiotics on appetite, inflammation, and nutritional status in overweight individuals.

Materials and Methods: The study includes 35 overweight females aged 19-30 years old to who a questionnaire form had been applied prior to the study. Probiotics were given to these individuals for 8 weeks. Food consumption records and anthropometric measurements were taken and a body composition analysis conducted three times during the study. Inflammatory markers such as CRP, TNF-α, and IL-6 and the hormone analyses (i.e., leptin, adiponectin, cholecystokinin, ghrelin, GLP-1, and PYY) were evaluated at the beginning and end of the study using the ELISA method.

Results: The women were asked about their physical activity status, and their appetite hormones and inflammatory markers were analyzed both at the beginning and end of the study. When taken together, the study found the individuals’ anthropometric measurements, inflammatory markers, and hunger hormone levels to have decreased significantly and their satiety hormone levels to have increased significantly after the use of probiotics (p<0.05). However, no significant changes occurred regarding their energy, macronutrients, fiber intake, or physical activity levels (p>0.05).

Conclusion: The study clearly shows an appropriate probiotic strain to be able to significantly affect anthropometric measurements, inflammatory markers, and appetite hormones in overweight individuals without any other intervention.

Anahtar Kelimeler

Obesity, probiotics, nutritional status, hormones, inflammatory markers

Proje Numarası

47/2019-08

PROBİYOTİKLERİN PRE-OBEZ KADINLARDA BESLENME DURUMU, AÇLIKTOKLUK HORMONLARI VE İNFLAMASYON DURUMU ÜZERİNE ETKİSİ

Öz

Amaç: Obezite dünyadaki en yaygın sağlık sorunlarından birisidir. Obezite tedavisinde güncel yöntemler; tıbbi beslenme tedavisi, davranış terapisi, tıbbi tedavi ve cerrahi tedavidir. Mevcut obezite tedavilerine yeni bir ek tedavi olarak açlık tokluk hormonlarının plazma düzeylerinin değiştirilmesinin besin tüketimini azaltıp azaltmayacağı halen tartışılmaktadır. Açlığı ve tokluğu kontrol eden hormonların düzeylerini değiştirme yöntemlerinden birisi probiyotik kullanımıdır. Bu çalışma hafif şişman bireylerde probiyotiklerin iştah, inflamasyon ve beslenme durumu üzerindeki etkilerini incelemek amacıyla planlanmış ve yürütülmüştür.

Gereç ve Yöntem: Bu çalışmaya yaşları 19-30 arasında değişen 35 hafif şişman kadın dahil edilmiştir ve çalışma öncesinde anket formu uygulanmıştır. Probiyotikler katılımcılara 8 hafta boyunca verilmiştir. Çalışma sırasında 3 kez besin tüketim kayıtları, antropometrik ölçümler ve vücut kompozisyonu analizi yapılmıştır. CRP, TNF-α ve IL-6 gibi inflamatuar belirteçler ve hormon analizleri (Leptin, Adiponektin, Kolesistokinin, Ghrelin, GLP-1, PYY) ELISA yöntemiyle çalışmanın başlangıcında ve sonunda değerlendirilmiştir.

Bulgular: Çalışmanın başında ve sonunda fiziksel aktivite durumu sorgulanmış olup, açlık tokluk hormonları ve inflamatuar belirteçler değerlendirilmiştir. Çalışmanın sonunda başlangıç durumuna göre antropometrik ölçümlerde, inflamatuar belirteçlerde ve açlık hormon düzeylerinin önemli ölçüde azaldığını ancak probiyotik kullanımı sonrasında tokluk hormonu düzeylerinin istatistiksel olarak anlamlı arttığını tespit edilmiştir (p<0,05). Ancak enerji, makrobesin, lif alımı ve fiziksel aktivite düzeyinde istatistiksel olarak fark olmadığı tespit edilmiştir (p>0,05).

Sonuç: Çalışmamız, uygun probiyotik suşunun kilolu bireylerde başka herhangi bir müdahaleye gerek kalmadan antropometrik ölçümleri, inflamatuar belirteçleri ve iştah hormonlarını önemli ölçüde etkileyebileceğini açıkça göstermektedir.

Anahtar Kelimeler

Obezite, probiyotikler, beslenme durumu, hormonlar, inflamatuar belirteçler

Proje Numarası

47/2019-08

Kaynakça

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