Plants Traditionally Used in the Treatment of Burns in Turkey

Yıl 2019, Cilt: 2 Sayı: 1, 15 - 35, 01.02.2019

Fatma Göç , Afife Mat

Öz

Burn is a serious and painful injury, which can be fatal. First aid to burn and its care is of most significance. Plants that are among the many different methods used in the treatment of burn throughout the ages are still being used by people. In this study, Turkey ethnobotanical researches have been examined and found ninety-seven species of plants that people use for burn healing. Researches on burn and wound healing activity of these plants or supportive healing process with pharmacological and biological activities were compiled. There are studies showing that burn healing activities are increased by enhancing wound contraction, cell proliferation, microcirculation and perfusion by demonstrating antimicrobial, anti-inflammatory, antioxidant, antinociceptive, analgesic, and astringent activity of phytochemicals in species especially Hypericum perforatum, Sesamum indicum, Brassica oleracea, Plantago major, Sambucus nigra, Aloe vera. The obtained data indicate that these plants are considered effective in the treatment of burns

Anahtar Kelimeler

Burn, wound, biological activity, etnobotanical use, traditional medicine

Türkiye’de Yanık Tedavisinde Geleneksel Olarak Kullanılan Bitkiler

Öz

Yanık, hayati tehlikelere varabilen ciddi ve acı veren bir yaralanmadır. Yanık yarasına ilk müdahale ve yara bakımı önemlidir. Çağlar boyunca yanık tedavisinde kullanılan birçok farklı yöntem arasında yer alan ve halk arasında yoğun kullanımı olan bitkilerin günümüzde de tedavi amaçlı kullanımı devam etmektedir. Bu çalışmada Türkiye’nin etnobotanik araştırmaları incelenerek halkın yanık tedavisinde kullandığı doksan yedi tür bitki tespit edilmiştir. Bu bitkilerin yanık ve yara iyileştirici aktivitelerinin ya da bu iyileşmeyi destekleyici olabilecek farmakolojik ve biyolojik aktivitelerinin yer aldığı araştırmalar derlenmiştir. Özellikle Hypericum perforatum, Sesamum indicum, Brassica oleracea, Plantago major, Sambucus nigra, Aloe vera gibi bazı türlerin içerdikleri fitokimyasallar sebebiyle antimikrobiyal, antienflamatuvar, antioksidan, antinosiseptif, analjezik, astrenjan aktivite göstermek suretiyle yara kontraksiyonu, hücre proliferasyonu, mikrosirkülasyon ve perfüzyonu arttırarak belirgin yanık iyileştirici aktivitelerinin ortaya konulduğu çalışmalar mevcuttur. Elde edilen veriler, bu bitkilerin yanık tedavisinde etkili kabul edildiklerini göstermektedir.

Anahtar Kelimeler

Yanık, yara, biyolojik aktivite, etnobotanik kullanım, geleneksel tedavi

Kaynakça

• Abdollahi F., Shafaghat A., Salimi F. (2012): Biological activity and a biflavonoit from Hypericum scabrum extracts, Journal of Medicinal Plants Research, 6(11): 2131-2135.
• Ahmadiani A., Fereidoni M., Semnanian S., Kamalinejad M., Saremi S. (1998): Antinociceptive and anti-inflammatory effects of Sambucus ebulus rhizome extract in rats, Journal of ethnopharmacology, 61(3): 229- 235.
• Akhbari M., Batooli H., Kashi F.J. (2012): Composition of essential oil and biological activity of extracts of Viola odorata L. from central Iran, Natural product research, 26(9): 802-809
• Aktan T. (2011): Yenişehir (Bursa) Köylerinin Etnobotanik Özellikleri, Yüksek Lisans Tezi, Celal Bayar Üniversitesi Fen Bilimleri Enstitüsü, Manisa.
• Albayrak S., Aksoy A., Sagdic O., Hamzaoglu E. (2010): Compositions, antioxidant and antimicrobial activities of Helichrysum (Asteraceae) species collected from Turkey, Food Chemistry, 119(1): 114-122.
• Ali-Shtayeh M.S., Yaghmour R.M.R., Faidi Y.R., Salem K., Al-Nuri M.A. (1998): Antimicrobial activity of 20 plants used in folkloric medicine in the Palestinian area, Journal of Ethnopharmacology, 60(3): 265-271.
• Al-Qudah M.A. (2013): Chemical composition and antimicrobial activity of the essential oil of Linum pubescens growing wild in Jordan, Natural product research, 27(12): 1141-1144.
• Al‐Saikhan M.S., Howard L.R., Miller J.C. (1995): Antioxidant activity and total phenolics in different genotypes of potato (Solanum tuberosum L.), Journal of Food Science, 60(2): 341-343.
• Al-Saimary I.E. ve ark. (2002): Effects of some plant extracts and antibiotics on Pseudomonas aeruginosa isolated from various burn cases, Saudi medical journal, 23(7): 802-805
• Altundağ E., Öztürk M. (2011): Ethnomedicinal Studies on The Plant Resources of East Anatolia, Turkey, Procedia Social and Behavioral Sciences, 19: 756-777
• Al-Waili N.S. (2005): Mixture of honey, beeswax and olive oil inhibits growth of Staphylococcus aureus and Candida albicans, Archives of medical research, 36(1): 10-13
• Amarowicz R., Karamac M., Shahidi F. (2003): Antioxidant activity of phenolic fractions of lentil (Lens culinaris), Journal of Food Lipids, 10(1): 1-10.
• Amensour M., Sendra E., Abrini J., Perez-Alvarez J.A., Fernández-López J. (2010): Antioxidant activity and total phenolic compounds of myrtle extracts Actividad antioxidante y contenido de compuestos fenólicos totales en extractos de myrtus, CyTA– Journal of Food, 8(2): 95-101.
• Amini M. ve ark. (2010): Effect of Plantago major on burn wound healing in rat, Journal of Applied Animal Research, 37(1): 53-56.
• Apaydın S. ve ark. (1999): Hypericum triquetrifolium Turra. extract exhibits antinociceptive activity in the mouse, Journal of ethnopharmacology, 67(3): 307- 312.
• Arık M. (2003): Korkut (Muş) İlçesi ve Köylerinin Faydalı Bitkileri, Yüksek Lisans Tezi, Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü, Van.
• Arıtuluk Z. C. (2010): Tefenni (Burdur) İlçesinin Florası ve Halk İlaçları, Yüksek Lisans Tezi, Hacettepe Üniversitesi Sağlık Bilimleri Enstitüsü, Ankara
• Asgary S. ve ark. (2013): Chemical analysis and biological activities of Cupressus sempervirens var. horizontalis essential oils, Pharmaceutical biolog
• Atas A.D., ve ark. (2012): Chemical composition, antioxidant, antimicrobial and antispasmodic activities of the essential oil of Juniperus excelsa subsp. excelsa, Journal of Essential Oil Bearing Plants, 15(3): 476-483.
• Aydın S., Öztürk Y., Beis R., Hüsnü Can Başer K. (1996): Investigation of Origanum onites, Sideritis congesta and Satureja cuneifolia essential oils for analgesic activity, Phytotherapy Research, 10(4): 342- 344.
• Bahadır Ö. ve ark. (2010): Analgesic compounds from Scorzonera latifolia (Fisch. and Mey.) DC, Journal of ethnopharmacology, 131(1): 83-87.
• Bahadır-Acıkara ve ark. (2014): Assessment of Anti- Inflammatory and Free Radical Scavenger Activities of Selected Scorzonera Species and Determination of Active Components, International Journal of Pharmacognosy and Phytochemical Research, 6(1): 59-65.
• Baloch N., Nabi S., Al-Kahraman Y.M. (2013): In vitro Antimicrobial, Insecticidal, Antitumor Activities and Their Phytochemical Estimation of Methanolic Extract and its Fractions of Medicago lupulina Leaves, World Applied Sciences Journal, 23(4): 500-506.
• Barla A., Öztürk M., Kültür Ş., Öksüz S. (2007): Screening of antioxidant activity of three Euphorbia species from Turkey, Fitoterapia, 78(6): 423-425.
• Baydar H., Sağdıç O., Özkan G., Karadoğan T. (2004): Antibacterial activity and composition of essential oils from Origanum, Thymbra and Satureja species with commercial importance in Turkey, Food Control, 15(3): 169-172
• Baytop T. (1984): Türkiye’de Bitkilerle Tedavi (Geçmişte ve Bugün). 2. Baskı. İstanbul: Nobel Tıp Kitabevleri
• Biswas A.R., Ramaswamy S., Bapna J.S. (1991): Analgesic effect of Momordica charantia seed extract in mice and rats, Journal of ethnopharmacology, 31(1): 115-118.
• Bonina F. ve ark. (2000): In‐vitro Antioxidant and In‐vivo Photoprotective Effect of Three Lyophilized Extracts of Sedum telephium L. Leaves, Journal of pharmacy and pharmacology, 52(10): 1279-1285.
• Braca A., Siciliano T., D’Arrigo M., Germanò M.P. (2008): Chemical composition and antimicrobial activity of Momordica charantia seed essential oil, Fitoterapia, 79(2): 123-125.
• Bulut G., Tuzlacı E. (2013): An Ethnobotanical Study of Medicinal Plants in Turgutlu (Manisa/Turkey), Journal of Ethnopharmacology, 149: 633-647
• Bursal E., Köksal E. (2011): Evaluation of reducing power and radical scavenging activities of water and ethanol extracts from sumac (Rhus coriaria L.), Food Research International, 44(7): 2217-2221.
• Cavallito C.J., Bailey J.H., Kirchner F.K. (1945): The antibacterial principle of Arctium minus. Isolation, physical properties and antibacterial action, Journal of the American Chemical Society, 67(6): 948-950
• Ćetković G.S., Djilas S.M., Čanadanović-Brunet, J.M., Tumbas V.T. (2004): Antioxidant properties of marigold extracts, Food Research International, 37(7): 643-650.
• Chandran P.K., Kutta, R. (2008): Effect of Calendula officinalis flower extract on acute phase proteins, antioxidant defense mechanism and granuloma formation during thermal burns, Journal of clinical biochemistry and nutrition, 43(2): 58.
• Chithra P., Sajithlal G.B., Chandrakasan G. (1998): Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats, Molecular and cellular biochemistry, 181(1-2): 71-76.
• Cioaca C., Margineanu C., Cucu V. (1978): The saponins of Hedera helix with antibacterial activity, Pharmazie, 33: 609–610
• Conforti F. ve ark. (2008): In vivo anti-inflammatory and in vitro antioxidant activities of Mediterranean dietary plants, Journal of Ethnopharmacology, 116(1): 144-151.
• Çakılcıoğlu U., Türkoğlu İ., Kürşat M. (2007): Harput (Elâzığ) ve Çevresinin Etnobotanik Özellikleri, Doğu Anadolu Bölgesi Araştırmaları Dergisi, 5(2): 22-28.
• Çetinkale O. (2001): İ.Ü. Cerrahpaşa Fakültesi Sürekli Tıp Eğitimi Etkinlikleri, “Yanık Yarası ve Tedavisi”, Cilt Hastalıkları ve Yara Bakımı Sempozyumu; sayfa 89-103
• Dalar A., Türker M., Konczak I. (2012): Antioxidant capacity and phenolic constituents of Malva neglecta Wallr. and Plantago lanceolata L. from Eastern Anatolia Region of Turkey, Journal of Herbal Medicine, 2(2): 42-51.
• Dawidowicz A.L., Wianowska D., Baraniak B. (2006): The antioxidant properties of alcoholic extracts from Sambucus nigra L. (antioxidant properties of extracts), LWT-Food science and Technology, 39(3): 308-315.
• Demi̇r A., Taban B.M., Aslan M., Yesi̇lada E., Aytac S.A. (2009): Antimicrobial effect of Helichrysum plicatum subsp. plicatum, Pharmaceutical Biology, 47(4): 289-297.
• Demirci S. (2010): Andırın (Kahramanmaraş) İlçesinde Etnobotanik Bir Araştırma, Yüksek Lisans Tezi, İstanbul Üniversitesi, Sağlık Bilimleri Enstitüsü, İstanbul.
• Dığrak M., İlçim A., Hakkı Alma M. (1999): Antimicrobial activities of several parts of Pinus brutia, Juniperus oxycedrus, Abies cilicia, Cedrus libani and Pinus nigra, Phytotherapy Research, 13(7): 584-587.
• Dostbil N., Seçkin H., Atasoy N., Özdek U. (2010): Solanaceae Familyasına Ait Bazı Bitkilerin Antibakteriyal Etkisi, 24. Ulusal Kimya Kongresi, Zonguldak Karaelmas Üniversitesi.
• Dudonné S. ve ark. (2011): Phenolic composition and antioxidant properties of poplar bud (Populus nigra) extract: individual antioxidant contribution of phenolics and transcriptional effect on skin aging, Journal of agricultural and food chemistry, 59(9): 4527-4536.
• Ecevit-Genç G. (2003): Çatalca İlçesinde Etnobotanik Bir Araştırma, Yüksek Lisans Tezi, İstanbul Üniversitesi Sağlık Bilimleri Enstitüsü, İstanbul.
• Efstratiou E. ve ark. (2012): Antimicrobial activity of Calendula officinalis petal extracts against fungi, as well as Gram-negative and Gram-positive clinical pathogens, Complementary Therapies in Clinical Practice, 18(3): 173-176.
• Eidi, A., Moghadam-kia, S., Moghadam, J. Z., Eidi, M., Rezazadeh, S. (2012): Antinociceptive and anti- inflammatory effects of olive oil (Olea europeae L.) in mice. Pharmaceutical biology, 50(3): 332-337.
• Emre-Bulut G. (2008): Bayramiç (Çanakkale) İlçesinde Etnobotanik Araştırmalar, Doktora Tezi, Marmara Üniversitesi Sağlık Bilimleri Enstitüsü, İstanbul.
• Erdemoğlu N., Küpeli E., Yeşilada E. (2003): Anti- inflammatory and antinociceptive activity assessment of plants used as remedy in Turkish folk medicine, Journal of Ethnopharmacology, 89(1): 123-129
• Erdemoğlu N., Turan N.N., Akkol E.K., Sener B., Abacıoglu N. (2009): Estimation of anti- inflammatory, antinociceptive and antioxidant activities on Arctium minus (Hill) Bernh. ssp. minus, Journal of ethnopharmacology, 121(2): 318-323.
• Erdoğan R. (2011): Sarıveliler (Karaman) ve Çevresinde Yetişen Bitkilerin Etnobotanik Özellikleri, Yüksek Lisans Tezi, Selçuk Üniversitesi Fen Bilimleri Enstitüsü, Konya.
• Fakir H., Korkmaz M., Güller B. (2009): Medicinal Plant Diversity of Western Mediterrenean Region in Turkey, Journal of Applied Biological Science, 3(2): 30-40
• Fezai M., Senovilla L., Jemaà M., Ben-Attia M. (2013): Analgesic, anti-inflammatory and anticancer activities of extra virgin olive oil, Journal of lipids, 2013
• Fronza M., Heinzmann B., Hamburger M., Laufer S., Merfort I. (2009): Determination of the wound healing effect of Calendula extracts using the scratch assay with 3T3 fibroblasts, Journal of ethnopharmacology, 126(3): 463-467.
• Gazim Z.C., Rezende C.M., Fraga S.R., Svidzinski T.I.E., Cortez D.A.G. (2008): Antifungal activity of the essential oil from Calendula officinalis L. (Asteraceae) growing in Brazil, Brazilian Journal of Microbiology, 39(1): 61-63.
• Gill N. ve ark. (2010): Evaluation of antioxidant, anti- inflammatory and analgesic potential of Citrullus lanatus seed extract in rodent model, The Internet Journal of Nutrition and Wellness, 9(2).
• Guil-Guerrero J.L., Rebolloso-Fuentes M.M. (2009): Nutrient composition and antioxidant activity of eight tomato (Lycopersicon esculentum) varieties, Journal of Food Composition and Analysis, 22(2): 123-129
• Günbatan T. (2011): Çamlıdere (Ankara) Halk İlaçları, Yüksek Lisans Tezi, Gazi Üniversitesi Sağlık Bilimleri Enstitüsü, Ankara.
• Güneş F., Özhatay N. (2011): An Ethnobotanical Study from Kars (Eastern) Turkey, Biological Diversity and Conservation, 4(1): 30-41
• Güneş S. (2010): Karaisalı (Adana) ve Köylerinde Halkın Kullandığı Doğal Bitkilerin Etnobotanik Yönden İncelenmesi, Yüksek Lisans Tezi, Niğde Üniversitesi Fen Bilimleri Enstitüsü, Niğde.
• Gürdal B. (2010): Marmaris (Muğla) İlçesinde Etnobotanik Bir Araştırma, Yüksek Lisans Tezi, İstanbul Üniversitesi Sağlık Bilimleri Enstitüsü, İstanbul.
• Güvenç A. ve ark. (2005): Antimicrobiological Studies on Turkish Cistus Species, Pharmaceutical biology, 43(2): 178-183.
• Güvenç A., Küpeli Akkol E., Hürkul M.M., Süntar İ., Keleş H. (2012): Wound healing and anti- inflammatory activities of the Michauxia L’Herit (Campanulaceae) species native to Turkey, Journal of ethnopharmacology, 139(2): 401-408.
• Haider S., Nazreen S., Alam M.M., Hamid H., Alam M.S. (2012): Anti-inflammatory and anti- nociceptive activities of Platanus orientalis Linn. and its ulcerogenic risk evaluation, Journal of ethnopharmacology, 143(1): 236-240.
• Hassan L.E.A., Sirat H.M., Yagi S.M.A., Koko W.S., Abdelwahab S.I. (2011): In vitro Antimicrobial activities of chloroformic, hexane and ethanolic extracts of Citrullus lanatus var. citroides (Wild melon), J Med. Plants Res, 5: 1338-1344.
• Hassanzadeh G. ve ark. (2013): Comparing effects of Silver sulfadiazine, Sukralfat ve Brassica oleracea extract on burn wound healing, Life Science Journal, 10(6s)
• Hayouni E.A. ve ark. (2011): Hydroalcoholic extract based-ointment from Punica granatum L. peels with enhanced in vivo healing potential on dermal wounds, Phytomedicine, 18(11): 976-984.
• Hayta Ş., Polat R., Selvi S. (2014): Traditional Uses of Medicinal Plants in Elâzığ (Turkey), Journal of Ethnopharmacology, 154: 613-623
• Hearst C. ve ark. (2010): Antibacterial activity of elder (Sambucus nigra L.) flower or berry against hospital pathogens, Journal of Medicinal Plants Research, 4(17): 1805-1809.
• Heimler D., Isolani L., Vignolini P., Romani A. (2009): Polyphenol content and antiradical activity of Cichorium intybus L. from biodynamic and conventional farming, Food Chemistry, 114(3): 765-770.
• Hemmati A.A., Aghel N., Rashidi I., Gholampur‐ Aghdami A. (2011): Topical grape (Vitis vinifera) seed extract promotes repair of full thickness wound in rabbit, International wound journal, 8(5): 514-520.
• Honda G. ve ark. (1996): Traditional Medicine in Turkey VI. Folk Medicine in West Anatolia: Afyon, Kütahya, Denizli, Muğla, Aydın provinces, Journal of Ethnopharmacology, 53: 75-87
• Hosseinzadeh H., Khoshdel M., Ghorbani M. (2011): Antinociceptive, anti-inflammatory effects and acute toxicity of aqueous and ethanolic extracts of Myrtus communis L. Aerial Parts in mice, Journal of acupuncture and meridian studies, 4(4): 242-247.
• Hupkens P., Boxma H., Dokter J. (1995): Tannic acid as a topical agent in burns: historical considerations and implications for new developments, Burns, 21(1): 57-61
• Hwangbo C., Lee H.S., Park J., Choe J., Lee J.H. (2009): The anti-inflammatory effect of tussilagone, from Tussilago farfara, is mediated by the induction of heme oxygenase-1 in murine macrophages, International immunopharmacology, 9(13): 1578-1584.
• Janovska D., Kubikova K., Kokoska L. (2003): Screening for antimicrobial activity of some medicinal plants species of traditional Chinese medicine, Czech journal of food sciences, 21(3): 107-110.
• Jerković I. ve ark. (2012): Volatile organic compounds from Centaurium erythraea Rafn (Croatia) and the antimicrobial potential of its essential oil, Molecules, 17(2): 2058-2072.
• Kaithwas G., Mukherjee A., Chaurasia A.K., Majumdar D.K. (2011): Antiinflammatory, analgesic and antipyretic activities of Linum usitatissimum L.(flaxseed/linseed) fixed oil, Indian Journal of Experimental Biology, 49: 932-938
• Karun S. Yanıklar, Op. Dr. Sadullah Karun Estetik ve Plastik Cerrahi Uzmanı: http://www. drsadullahkarun.com/Yanıklar-3.aspx (03.03.2015)
• Keklik-Koçoğlu T., Çubukçu B., Özhatay N. (1996): Konya ve Karaman İlleri Halk İlaçları, Geleneksel ve Folklorik İlaçlar Dergisi, 3(1): 1-35
• Khorasani G., Hosseinimehr S.J., Azadbakht M., Zamani A., Mahdavi M.R. (2009): Aloe versus silver sulfadiazine creams for second-degree burns: a randomized controlled study, Surgery today, 39(7): 587-591.
• Khoury M., El Beyrouthy M., Ouaini N., Iriti M., Eparvier V., Stien D. (2014): Chemical Composition and Antimicrobial Activity of the Essential Oil of Juniperus excelsa M. Bieb. Growing Wild in Lebanon, Chemistry & biodiversity, 11(5): 825-830.
• Kızıl G., Kizil M., Yavuz M., Emen S., Hakimoglu, F. (2008): Antioxidant Activities of Ethanol Extracts of Hypericum triquetrifolium and Hypericum scabroides, Pharmaceutical Biology, 46(4): 231-242.
• Kızıl G., Toker Z., Özen H.Ç., Aytekin C. (2004): The antimicrobial activity of essential oils of Hypericum scabrum, Hypericum scabroides and Hypericum triquetrifolium, Phytotherapy Research, 18(4): 339-341
• Kızılarslan Ç. (2008): İzmit Körfezinin Güney Kesiminde Etnobotanik Bir Araştırma, Yüksek Lisans Tezi, İstanbul Üniversitesi Sağlık Bilimleri Enstitüsü, İstanbul.
• Kim M.R. ve ark. (2006): Antioxidative effects of quercetin-glycosides isolated from the flower buds of Tussilago farfara L., Food and chemical toxicology, 44(8): 1299-1307.
• Kimura Y., Sumiyashi M., Sahanaka M. (2007): Effects of Astilbe thunbergii rhizomes on wound healing Part 1. Isolation of promotional effectors from Astilbe thunbergii rhizomes on burn wound healing, Journal of Ethnopharmacology, 109: 72- 77
• Kiran K., Asad M. (2008): Wound healing activity of Sesamum indicum L. seed and oil in rats, Indian journal of experimental biology, 46(11): 777.
• Koçyiğit M. (2005): Yalova İlinde Etnobotanik Bir Araştırma, Yüksek Lisans Tezi, İstanbul Üniversitesi Sağlık Bilimleri Enstitüsü, İstanbul.
• Kolacz N.M., Jaroch M.T., Bear M.L., Hess R.F. (2014): The Effect of Burns & Wounds (B&W) /Burdock Leaf Therapy on Burn-Injured Amish Patients A Pilot Study Measuring Pain Levels, Infection Rates and Healing Times, Journal of Holistic Nursing, 32(4): 327-340.
• Kolaylı S., Küçük M., Duran C., Candan F., Dinçer B. (2003): Chemical and antioxidant properties of Laurocerasus officinalis Roem. (cherry laurel) fruit grown in the Black Sea region, Journal of agricultural and food chemistry, 51(25): 7489
• Koltka K. (2011): Yanık Yaralanmaları: Yanık Derinliği, Fizyopatolojisi ve Yanık Çeşitleri. Türk Yoğun Bakım Derneği Dergisi, 9: 1-6
• Kostic D.A. ve ark. (2010): Phenolic contents, antioxidant and antimicrobial activity of Papaver rhoeas L. extracts from Southeast Serbia, Journal of Medicinal Plants Research, 4(17): 1727-1732.
• Koyuncu O., Yaylacı Ö.K., Tokur S. (2009): Geyve (Sakarya) ve çevresinin etnobotanik açıdan incelenmesi, Ot Sistematik Botanik Dergisi, 16(1): 123-142
• Kumar P., Sharma B., Bakshi N. (2009): Biological activity of alkaloids from Solanum dulcamara L., Natural product research, 23(8): 719-723.
• Kumarasamy Y., Cox P.J., Jaspars M., Nahar L., Sarker S.D. (2002): Screening seeds of Scottish plants for antibacterial activity, J Ethnopharmacol, 83: 73–77.
• Kumari A. ve ark. (2013): Analgesic Activity of Aqueous Extract of Citrullus Lanatus Peels, Advances in Pharmacology and Pharmacy, 1(3): 135-138.
• Kuruüzüm-Uz A., Süleyman H., Çadırcı E., Güvenalp Z., Demirezer L.O. (2012): Investigation on anti- inflammatory and antiulcer activities of Anchusa azurea extracts and their major constituent rosmarinic acid, Zeitschrift fur Naturforschung C, 67(7-8): 360-366
• Küpeli E., Tatli I.I., Akdemir Z.S., Yesilada E. (2007): Bioassay-guided isolation of anti-inflammatory and antinociceptive glycoterpenoids from the flowers of Verbascum lasianthum Boiss. ex Bentham., Journal of ethnopharmacology, 110(3): 444-450.
• Küpeli-Akkol E. ve ark. (2011): Enhancement of wound healing by topical application of Scorzonera species: Determination of the constituents by HPLC with new validated reverse phase method, Journal of ethnopharmacology, 137(2): 1018-1027.
• Küpeli-Akkol E. ve ark. (2009): Exploring the wound healing activity of Arnebia densiflora (Nordm.) Ledeb. by in vivo models, Journal of ethnopharmacology, 124(1): 137-141.
• Lakić N.S., Mimica-Dukić N.M., Isak J.M., Božin B.N. (2010): Antioxidant properties of Galium verum L. (Rubiaceae) extracts, Central European Journal of Biology, 5(3): 331-337.
• Lavagna S.M. ve ark. (2001): Efficacy of Hypericum and Calendula oils in the epithelial reconstruction of surgical wounds in childbirth with caesarean section, Farmaco, 56(5): 451-453.
• Liu C.H. ve ark. (2010): Antioxidant triterpenoids from the stems of Momordica charantia, Food chemistry, 118(3): 751-756.
• Mahboubi M., Haghi G. (2008): Antimicrobial activity and chemical composition of Mentha pulegium L. essential oil, Journal of ethnopharmacology, 119(2): 325-327.
• Mahmood A.A., Phipps M.E. (2006): Wound healing activities of Plantago major leaf extract in rats, International Journal of Tropical Medicine, 1(1): 33-35.
• Manabe M., Takenaka R., Nakasa T., Okinaka O. (2003): Induction of anti-inflammatory responses by dietary Momordica charantia L. (bitter gourd), Bioscience, biotechnology, and biochemistry, 67(12): 2512-2517.
• Marčetić M. ve ark. (2013): Antimicrobial, 121. Nayak B.S. ve ark. (2010): Wound‐healing activity of antioxidant and anti‐inflammatory activity of young shoots of the smoke tree, Cotinus coggygria Scop., Phytotherapy Research, 27(11): 1658-1663.
• Meriç Z.İ., Bitiş L., Birteksöz-Tan S., Özbaş Turan S., Akbuga J. (2014): Antioxidant, antimicrobial and anticarcinogenic activities of Sambucus ebulus L. flowers, fruits and leaves, Marmara Pharmaceutical Journal, 18: 22-25
• Metin A. (2009): Mut (Mersin) ve Çevresinde Yetişen Bitkilerin Etnobotanik Özellikleri, Yüksek Lisans Tezi, Selçuk Üniversitesi Fen Bilimleri Enstitüsü, Konya.
• Miceli A. ve ark. (2014): Antibacterial activity of Borago officinalis and Brassica juncea aqueous extracts evaluated in vitro and in situ using different food model systems, Food Control, 40: 157-164.
• Mogoşanu G.D. ve ark. (2011): The effect of a topical treatment based on Sambuci flos extract in experimental thermal third degree skin burns, Studia Universitatis “Vasile Goldiş” Arad, Seria Ştiinţele Vieţii (Life Sciences Series), 21(4): 701-708.
• Mohajeri G. ve ark. (2010): The effect of dressing with fresh kiwifruit on burn wound healing, Surgery, 148(5): 963-968
• Moulin-Traffort J., Favel A., Elias R., Regli P. (1998): Study of the action of alpha-hederin on the ultrastructure of Candida albicans, Mycoses, 41: 411–416
• Muley B.P., Khadabadi S.S., Banarase N.B. (2009): Phytochemical constituents and pharmacological activities of Calendula officinalis Linn (Asteraceae): A review, Tropical Journal of Pharmaceutical Research, 8(5).
• Mükemre M. (2013): Kanalga, Sırmalı, Dokuzdam Köyleri (Çatak-Van) ve Çevrelerinin Etnobotanik Özellikleri, Yüksek Lisans Tezi, Yüzüncüyıl Üniversitesi Fen Bilimleri Enstitüsü, Van.
• Najmi M., Shariatpanahi Z.V., Tolouei M., Amiri Z. (2014): Effect of oral olive oil on healing of 10–20% total body surface area burn wounds in hospitalized patients, Burns, 41(3): 493-496. 120. Nasar-Abbas S.M., Halkman A.K. (2004): Antimicrobial effect of water extract of sumac (Rhus coriaria L.) on the growth of some food borne bacteria including pathogens, International journal of food microbiology, 97(1): 63-69. the skin of the common grape (Vitis vinifera) variant, cabernet sauvignon, Phytotherapy Research, 24(8): 1151-1157
• Neto C.C. ve ark. (2002): Antibacterial activity of some Peruvian medicinal plants from the Callejon de Huaylas, Journal of ethnopharmacology, 79(1): 133-138.
• Novaković M. ve ark. (2007): Chemical composition, antibacterial and antifungal activity of the essential oils of Cotinus coggygria from Serbia, Journal of the Serbian Chemical Society, 72(11): 1045-1051.
• Nşñez Guillén M.E., da Silva Emim, J.A., Souccar C., Lapa A.J. (1997): Analgesic and Anti-inflammatory Activities of the Aqueous Extract of Plantago major L., Pharmaceutical Biology, 35(2): 99-104
• Ocsel H. ve ark. (2012): Effects of oriental sweet gum storax on porcine wound healing, Journal of Investigative Surgery, 25(4): 262-270.
• Oktayoğlu E.E. (2004): Hypericum montbretii Spach türünün hiperisin miktarı ve biyolojik aktiviteleri yönünden incelenmesi, Yüksek Lisans Tezi, İstanbul Üniversitesi Sağlık Bilimleri Enstitüsü, İstanbul.
• Oomah B.D., Corbé A., Balasubramanian P. (2010): Antioxidant and anti-inflammatory activities of bean (Phaseolus vulgaris L.) hulls, Journal of agricultural and food chemistry, 58(14): 8225-8230.
• Orhan D.D., Hartevioğlu A., Küpeli E., Yesilada E. (2007): In vivo anti-inflammatory and antinociceptive activity of the crude extract and fractions from Rosa canina L. fruits, Journal of ethnopharmacology, 112(2): 394-400.
• Oskay M., Aktaş K., Sarı D., Azeri C. (2007): Asphodelus aestivus (Liliaceae)’un antimikrobiyal etkisinin çukur ve disk diffüzyon yöntemiyle karşılaştırmalı olarak belirlenmesi, Ekoloji, 62: 62-65.
• Özkan A., Erdoğan A. (2011): A comparative evaluation of antioxidant and anticancer activity of essential oil from Origanum onites (Lamiaceae) and its two major phenolic components, Turkish Journal of Biology, 35(6): 735-742
• Özkan G., Sagdiç O., Göktürk Baydar N., Kurumahmutoglu Z. (2004): Antibacterial activities and total phenolic contents of grape pomace extracts, Journal of the Science of Food and Agriculture, 84(14): 1807-1811
• Öztürk B., Apaydin S., Goldeli E., Ince I., Zeybek U. (2002): Hypericum triquetrifolium Turra. extract exhibits antiinflammatory activity in the rat, Journal of Ethnopharmacology, 80(2): 207-209.
• Öztürk N., Korkmaz S., Öztürk Y. (2007): Wound- healing activity of St. John’s Wort (Hypericum perforatum L.) on chicken embryonic fibroblasts, Journal of ethnopharmacology, 111(1): 33-39.
• Paduch R. ve ark. (2008): Lamium album extracts express free radical scavenging and cytotoxic activities, Polish Journal of Environmental Studies, 17(4): 569-580
• Parsaeihmehr A., Chen Y.F., Sargsyan E. (2014): Bioactive Molecules of Herbal Extracts with Anti-Infective and Wound Healing Properties, In Microbiology for Surgical Infections, 205-220.
• Patrick K.F.M., Kumar S., Edwardson P.A.D.
• Hutchinson J.J. (1996): Induction of vascularisation by an aqueous extract of the flowers of Calendula officinalis L. the European marigold, Phytomedicine, 3(1): 11-18.
• Peksel A., Imamoglu S., Altas Kiymaz N., Orhan N. (2013): Antioxidant and radical scavenging activities of Asphodelus aestivus Brot. Extracts, International Journal of Food Properties, 16(6): 1339-1350.
• Pereira J.A. ve ark. (2007): Walnut (Juglans regia L.) leaves: phenolic compounds, antibacterial activity and antioxidant potential of different cultivars, Food and Chemical Toxicology, 45(11): 2287-2295.
• Piana M. (2013): Antiinflammatory effects of Viola tricolor gel in a model of sunburn in rats and the gel stability study, Journal of ethnopharmacology, 150(2): 458-465.
• Polat R., Satıl F. (2012): An Ethnobotanical Survey of Medicinal Plants in Edremit Gulf, Journal of Ethnopharmacology, 139: 626-641
• Rani P., Khullar N. (2004): Antimicrobial evaluation of some medicinal plants for their anti‐enteric potential against multi‐drug resistant Salmonella typhi, Phytotherapy Research, 18(8): 670-673.
• Reichling J., Weseler A., Saller R. (2001): A current review of the antimicrobial activity of Hypericum perforatum L., Pharmacopsychiatry, 34(1): 116-118.
• Rodriguez-Bigas M., Cruz N.I., Suarez A. (1988): Comparative evaluation of Aloe vera in the management of burn wounds in guinea pigs, Plastic and reconstructive surgery, 81(3): 386-389.
• Rosa A.D.S., Bandeira L.G., Monte‐Alto‐Costa 155. Sayar A., Güvensen A., Özdemir F., Öztürk M.
• A., Romana‐Souza B. (2014): Supplementation with olive oil, but not fish oil, improves cutaneous wound healing in stressed mice, Wound Repair and Regeneration, 22(4): 537-547.
• Sağdıç O., Özkan G., Özcan M., Özçelik S. (2005): A study on inhibitory effects of Sığla tree (Liquidambar orientalis Mill. var. orientalis) storax against several bacteria, Phytotherapy Research, 19(6): 549-551.
• Sakar M.K., Tamer A.Ü. (1990): Antimicrobial activity of different extracts from some Hypericum species, Fitoterapia, 61(5): 464-466.
• Salehzadeh A., Asadpour L., Naeemi A.S., Houshmand E. (2014): Antimicrobial Activity 159. Shagal M.H., Modibbo U.U., Liman A.B. (2012): of Methanolic Extracts of Sambucus ebulus and Urtica dioica Against Clinical Isolates of Methicillin Resistant Staphylococcus aureus, African Journal of Traditional, Complementary and Alternative Medicines, 11(5): 38-40.
• Saltan-Çitoğlu G., Altanlar N. (2003): Antimicrobial activity of some plants used in folk medicine, J. Fac. Pharm, Ankara. 32(3): 159-163.
• Saltan-Çitoğlu G., Çoban T., Sever B., Işcan M. (2004): Antioxidant properties of Ballota species growing in Turkey, Journal of ethnopharmacology
• Saraç, D.U. (2013): Rize İli Etnobotanik Özellikleri, Yüksek Lisans Tezi, Karadeniz Teknik Üniversitesi Fen Bilimleri Enstitüsü, Trabzon.
• Saraç N., Şen B. (2014): Antioxidant, mutagenic, antimutagenic activities, and phenolic compounds of Liquidambar orientalis Mill. var. orientalis, Industrial Crops and Products, 53: 60-64.
• Sargın S.A., Akçiçek E., Selvi, S. (2013): An Ethnobotanical Study of Medicinal Plants Used by The Local People of Alaşehir (Manisa) in Turkey, Journal of Ethnopharmacology, 150: 860-874
• Sarı A.O. ve ark. (2010): Ege ve Güney Marmara Bölgelerinde Halk İlacı Olarak Kullanılan Bitkiler, Anadolu J. Of AARI, 20(2): 1-21
• Sarikürkçü C. ve ark. (2012): Screening of the antioxidant activity of the essential oil and methanol extract of Mentha pulegium L. from Turkey, Spectroscopy Letters, 45(5): 352-358. (1995): Muğla İlindeki Bazı Türlerin Etnobotanik Özellikleri, Ot Sist. Bot. Der., 2(1): 151-160
• Sendl A., Wagner H., Mulinacci N., Vincier, F.F. (1993): Anti-inflammatory and immunologically active polysaccharides of Sedum telephium, Phytochemistry, 34(5): 1357-1362.
• Sezik E. ve ark. (1991): Traditional Medicine in Turkey I. Folk Medicine in Northeast Anatolia, Journal of Ethnopharmacology, 35: 191-196
• Sezik E. ve ark. (2001): Traditional Medicine in Turkey X. Folk Medicine in Central sAnatolia, Journal of Ethnopahrmacology,75: 95-115 Pharmacological justification for the ethnomedical use of Datura stramonium stem-bark extract in treatment of diseases caused by some pathogenic bacteria, Int Res Pharm Pharmacol, 2(1): 16-19.
• Shenoy C., Patil M.B., Kumar R., Patil S. (2009): Preliminary phytochemical investigation and wound healing activity of Allium cepa Linn (Liliaceae), International journal of pharmacy and pharmaceutical sciences, 2(2): 167-175. Sonika G., Manubala R., Deepak J. (2010): Comparative studies on anti-inflammatory activity of Coriandrum sativum, Datura stramonium and Azadirachta indica, Asian J Exp Biol Sci, 1(1): 151- 154.
• Süleyman H., Mshvildadze V., Gepdiremen A., Elias R. (2003): Acute and chronic antiinflammatory profile of the ivy plant, Hedera helix, in rats. Phytomedicine, 10: 370-374
• Süntar I.P. ve ark. (2010a): Wound healing potential of Sambucus ebulus L. leaves and isolation of an active component, quercetin 3-O-glucoside, Journal of ethnopharmacology, 129(1): 106-114.
• Süntar I.P. ve ark. (2010b): Investigations on the in vivo wound healing potential of Hypericum perforatum L., Journal of ethnopharmacology, 127(2): 468-477.
• Süntar I. ve ark. (2011a): A novel wound healing ointment: a formulation of Hypericum perforatum oil and sage and oregano essential oils based on traditional Turkish knowledge, Journal of ethnopharmacology, 134(1): 89-96
• Süntar I., Koca U., Keles H., Akkol E. K. (2011b): Wound healing activity of Rubus sanctus Schreber (Rosaceae): preclinical study in animal models, Evidence-Based Complementary and Alternative Medicine, doi:10.1093/ecam/nep137 2009.
• Süntar I., Tumen I., Ustün O., Keleş H., Akkol E.K. (2012a): Appraisal on the wound healing and anti- inflammatory activities of the essential oils obtained from the cones and needles of Pinus species by in vivo and in vitro experimental models, Journal of ethnopharmacology, 139(2): 533-540.
• Süntar İ., Küpeli-Akkol E., Nahar L. Sarker S.D. (2012b): Wound healing and antioxidant properties: do they coexist in plants.?, Free Radicals and Antioxidants, 2(2)
• Tabandeh M.R., Oryan A., Mohammadalipour A. (2014): Polysaccharides of Aloe vera induce MMP-3 and TIMP-2 gene expression during the skin wound repair of rat, International journal of biological macromolecules, 65: 424-430.
• Tabata M. ve ark. (1994): Traditional Medicine in Turkey III. Folk Medicine in East Anatolia, Van and Bitlis Provinces, Journal of Ethnopharmacology, 32: 3-12
• Teoh S.L., Latiff A.A., Das S. (2009): The effect of topical extract of Momordica charantia (bitter gourd) on wound healing in nondiabetic rats and in rats with diabetes induced by streptozotocin, Clinical and experimental dermatology, 34(7): 815-822.
• Termentzi A., Kefalas P., Kokkalou E. (2006): Antioxidant activities of various extracts and fractions of Sorbus domestica fruits at different maturity stages, Food chemistry, 98(4), 599-608.
• Tetik F. (2010). Malatya İlinin Etnobotanik Değeri Olan Bitkiler Üzerine Bir Araştırma, Yüksek Lisans Tezi, Fırat Üniversitesi Fen Bilimleri Enstitüsü, Elâzığ.
• Tian H., Zhang H., Zhan P., Tian F. (2011): Composition and antioxidant and antimicrobial activities of white apricot almond (Amygdalus communis L.) oil, European Journal of Lipid Science and Technology, 113(9): 1138-1144.
• Tomovic M.T. ve ark. (2015): Antioxidant and anti- inflammatory activity of Potentilla reptans L., Acta Poloniae Pharmaceutica-Drug Research, 72(1): 137- 145.
• Tumen I., Süntar I., Keleş H., Küpeli Akkol E. (2012): A therapeutic approach for wound healing by using essential oils of Cupressus and Juniperus species growing in Turkey. Evidence-Based Complementary and Alternative Medicine, doi: 10.1155/2012/728281.
• Tuzlacı E. (2005): Bodrum’da Bitkiler ve Yaşam, İstanbul: İstanbul Güzel Sanatlar Matbaası
• Tuzlacı E. (2016): Türkiye Bitkileri Gelenekel İlaç Rehberi, İstanbul: İstanbul Tıp Kitapevi
• Tuzlacı E., Alparslan İşbilen D.F., Bulut G. (2010): Turkish Folk Medicinal Plants VII: Lalapaşa (Edirne), Marmara Pharmaceutical Journal, 14: 47-52
• Tuzlacı E., Aymaz P.E. (2001): Turkish Folk Medicinal Plants Part IV: Gönen (Balıkesir), Fitoterapia, 72: 323-343
• Tuzlacı E., Doğan A. (2010): Turkish Folk Medicinal Plants IX: Ovacık (Tunceli), Marmara Pharmaceutical Journal, 14: 136-143
• Tuzlacı E., Erol M.K. (1999): Turkish Folk Medicinal Plants Part II: Eğirdir (Isparta), Fitoterapia, 70: 593- 610
• Tuzlacı E., Tolon E. (2000): Turkish Folk Medicinal Plants Part III: Şile (İstanbul), Fitoterapia, 71: 673- 685
• Ugulu İ., Baslar S., İlçek N., Doğan Y. (2009): The Investigation and Quantitative Ethnobotanical Evaluation of Medicinal Plants Used Around İzmir Province Turkey, Journal of Medicinal Plants Research, 3(5): 345-367
• Uysal G. (2008): Köyceğiz (Muğla) İlçesinin Etnobotaniği, Yüksek Lisans Tezi, Muğla Üniversitesi Fen Bilimleri Enstitüsü, Muğla.
• Uysal İ., Avcıoğlu N., Karabacak N. (2008): Çan İlçesinin Köylerinde kullanılan Tıbbi Bitkiler, Çanakkale On Sekiz Mart Üniversitesi Yayınları, 83: 127-142
• Uzun E. ve ark. (2004): Traditional Medicine in Sakarya Province (Turkey) and antimicrobial activities of selected species, Journal of Ethnopharmacology, 95: 287-296
• Ünal E.L. ve ark. (2008): Antimicrobial and
• antioxidant activities of some plants used as remedies in Turkish traditional medicine, Pharmaceutical Biology, 46(3): 207-224.
• Valentão P. ve ark. (2001): Antioxidant activity of Centaurium erythraea infusion evidenced by its superoxide radical scavenging and xanthine oxidase inhibitory activity, Journal of Agricultural and Food Chemistry, 49(7): 3476-3479.
• Valentão P. ve ark. (2002): Antioxidant activity of Hypericum androsaemum infusion: scavenging activity against superoxide radical, hydroxyl radical and hypochlorous acid, Biological and Pharmaceutical Bulletin, 25(10): 1320-1323.
• Vardar-Ünlü G., Silici S., Ünlü M. (2008): Composition and in vitro antimicrobial activity of Populus buds and poplar-type propolis, World Journal of Microbiology and Biotechnology, 24(7): 1011-1017
• Vazquez B., Avila G., Segura D., Escalante B. (1996): Antiinflammatory activity of extracts from Aloe vera gel, Journal of ethnopharmacology, 55(1): 69-75.
• Veličković D.T., Ranđelović N.V., Ristić M.S.
• Šmelcerović A.A., Veličković A.S. (2002): Chemical composition and antimicrobial action of the ethanol extracts of Salvia pratensis L. Salvia glutinosa L. and Salvia aethiopis L., Journal of the Serbian Chemical Society, 67(10): 639-646.
• Venskutonis P.R., Dvaranauskaite A., Labokas J. (2007): Radical scavenging activity and composition of raspberry (Rubus idaeus) leaves from different locations in Lithuania, Fitoterapia, 78(2): 162-165.
• Vigo E., Cepeda A., Gualillo O., Perez‐Fernandez R. (2005): In‐vitro anti‐inflammatory activity of Pinus sylvestris and Plantago lanceolata extracts: effect on inducible NOS, COX‐1, COX‐2 and their products in J774A. 1 murine macrophages, Journal of pharmacy and pharmacology, 57(3): 383-391.
• Wesołowska A., Nikiforuk A., Michalska K., Kisiel W., Chojnacka-Wójcik E. (2006): Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice, Journal of ethnopharmacology, 107(2): 254-258.
• Yapıcı İ. Ü., Hoşgören H., Saya Ö. (2009): Kurtalan (Siirt) İlçesinin Etnobotanik Özellikleri, Dicle Üniversitesi Ziya Gökalp Eğitim Fakültesi Dergisi, 12: 191- 196
• Yastı A.Ç., Özok G., Yorgancı K., Şenel E. (2012): T.C. Sağlık Bakanlığı Yanık Yaralanmaları ve Tedavi Algoritması, Türk Plastik Rekonstrüktif ve Estetik Cerrai Derneği: http://www.tpcd.org.tr/ Yanik.270.0.html (03.03. 2015).
• Yazıcıoğlu A., Tuzlacı E. (1996): Folk Medicinal Plants of Trabzon (Turkey), Fitoterapia, 67(4): 307- 318
• Yeşil Y. (2007): Kürecik (Akçadağ/Malatya) Bucağında Etnobotanik Bir Araştırma, Yüksek Lisans Tezi, İstanbul Üniversitesi Sağlık Bilimleri Enstitüsü, İstanbul.
• Yeşilada E. ve ark. (1995): Traditional Medicine in Turkey V. Folk Medicine in The Inner Taurus Mountains, Journal of Ethnopharmacology, 46: 133- 152
• Yeşilada E. ve ark. (1999): Traditional Medicine in Turkey IX: Folk Medicine in North-West Anatolia, Journal of Ethnopharmacology, 64: 195-210
• Yetkin H., Başak P.Y. (2006): Dermatolojide bitkisel tedavi, Türkderm, 40(2): 40-45.
• Yılmaz B.S. ve ark. (2006): Analgesic and hepatotoxic effects of Ononis spinosa L., Phytotherapy Research, 20(6): 500-503.
• Zare P. ve ark. (2012): Efficacy of chloroform, ethanol and water extracts of medicinal plants, Malva sylvestris and Malva neglecta on some bacterial and fungal contaminants of wound infections, J Med Plant Res, 6(29): 4550-4552.
• Zhao C.C. ve ark. (2006): A new anthraquinone from Galium verum L., Natural product research, 20(11): 981-984.