Ovaryan endometrozis ve D vitamini düzeyi arasındaki ilişki

Yıl 2022, Cilt: 9 Sayı: 3, 265 - 271, 01.09.2022

Ozlem Gursoy , Ceren Yıldız Eren , Hulusi Göktuğ Gürer

https://doi.org/10.52880/sagakaderg.1104058

Öz

OVARYAN ENDOMETROZİSDE D VİTAMİNİ DÜZEYLERİ
ÖZET
Giriş ve Amaç: D vitamininin endometriozis patogenezindeki potansiyel rolü araştırmacılar tarafından üzerinde çalışılan bir konudur. Bu çalışma, endometriozisin çeşitli özellikleri ile D vitamini düzeyleri arasındaki ilişkiyi araştırmak amacıyla yapılmıştır.
Gereç Yöntemler: Katılımcıların sosyodemografik özellikleri olarak yaş, parite ve sigara içme değişkenleri incelendi. Çalışmamızda incelenen diğer değişkenler evre, anti-Müllerian hormon ve D vitamini düzeyleri, endometriozisin, sağda veya solda, görüldüğü taraf, endometriozisin yaygınlığı ve infertilite durumudur. Tanımlayıcı istatistiksel yöntemler, korelasyon analizi, regresyon analizi, bağımsız örnekler t testi ve tek yönlü varyans analizi kullanılmıştır.
Bulgular: Korelasyon analizine göre kandaki D vitamini düzeyi ile evre arasında istatistiksel olarak anlamlı, orta düzeyde bir ilişki vardır. Regresyon modeline göre kandaki D vitamininin evre üzerinde olumsuz ve anlamlı bir etkisi vardır. Bu bulgulara göre D vitamini seviyesindeki düşüşün hastanın evre durumunu yükselteceği söylenebilir.
Sonuç: Araştırmanın birincil konusu olan D vitamini ile endometriozis arasındaki ilişki üç farklı istatistiksel yöntemle araştırıldı.

Anahtar Kelimeler

Endometriozis, D Vitamini, Anti-Müllerian Hormon, Parite, Sigara, İnfertilite.

Destekleyen Kurum

yok

Proje Numarası

yok

The relationship between ovarian endometrosis and vitamin D level

Öz

ABSTRACT
Introduction & Aim: The potential role of vitamin D in the pathogenesis of endometriosis is a subject that has been studied by researchers. This study was carried out to investigate the correlation between various features of endometriosis and vitamin D levels.
Material Methods: Age, parity and smoking variables of the participants were examined as socio-demographic characteristics. Other variables examined in our study are stage, anti-Müllerian hormone and vitamin D levels, the side where endometriosis is seen, either right or left, the extent of endometriosis and infertility status. Descriptive statistical methods, correlation analysis, regression analysis, independent samples t-test and one-way analysis of variance were used.
Results: According to the correlation analysis, there is a statistically significant, moderate relationship between the level of vitamin D in the blood and the stage. According to the regression model, vitamin D in the blood has a negative and significant effect on the stage. According to these findings, it can be said that the decrease in vitamin D level will increase the stage status of the patient.
Conclusions: The correlation between vitamin D and endometriosis, which is the primary subject of the research, was investigated with three different statistical methods.

Anahtar Kelimeler

Endometriosis, Vitamin D, Anti-Mullerian Hormone, Parity, Smoking, Infertility.

Proje Numarası

yok

Kaynakça

• 1. Chapron C, Marcellin L, Borghese B, Santulli P. (2019) Rethinking mechanisms, diagnosis and management of endometriosis. Nat Rev Endocrinol, 15(11):666–82.
• 2. Czyzyk A, Podfigurna A, Szeliga A, Meczekalski B. (2017) Update on endometriosis pathogenesis. Minerva Ginecol, 69(5):447–61.
• 3. Sizar O, Khare S, Goyal A, Bansal P, Givler A. (2022).Vitamin D Deficiency. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing.
• 4. Kalaitzopoulos DR, Lempesis IG, Athanasaki F, Schizas D, Samartzis EP, Kolibianakis EM, et al. (2020) Association between vitamin D and endometriosis: a systematic review. Hormones (Athens), 19(2):109–21.
• 5. Han SJ, O’Malley BW. (2014) The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis. Hum Reprod Update, 20(4):467–84.
• 6. Harris HR, Chavarro JE, Malspeis S, Willett WC, Missmer SA. (2013) Dairy-food, calcium, magnesium, and vitamin D intake and endometriosis: a prospective cohort study. Am J Epidemiol, 177(5):420–30.
• 7. Giampaolino P, Della Corte L, Foreste V, Bifulco G. (2019) Is there a Relationship Between Vitamin D and Endometriosis? An Overview of the Literature. Curr Pharm Des, 25(22):2421–7.
• 8. Chauhan K, Shahrokhi M HM. (2021) Vitamin D. StatPearls. Treasure Island (FL): StatPearls Publishing.
• 9. La Marca A, Spada E, Grisendi V, Argento C, Papaleo E, Milani S, et al. (2012) Normal serum anti-Müllerian hormone levels in the general female population and the relationship with reproductive history. Eur J Obstet Gynecol Reprod Biol,163(2):180–4.
• 10. American Society for Reproductive Medicine. (1996) Revised American Society for Reproductive Medicine classification of endometriosis:. Fertil Steril,67(5):817–21.
• 11. Esinler I, Bozdag G, Arikan I, Demir B, Yarali H. (2012) Endometrioma ≤3 cm in Diameter per se Does Not Affect Ovarian Reserve in Intracytoplasmic Sperm Injection Cycles. Gynecol Obstet Invest,74(4):261–4.
• 12. La Marca A, Spada E, Grisendi V, Argento C, Papaleo E, Milani S, et al. (2015) Maternal age and risk of labor and delivery complications. Matern Child Health J,19(6):1202–11.
• 13. Ciavattini A, Serri M, Delli Carpini G, Morini S, Clemente N. (2017) Ovarian endometriosis and vitamin D serum levels. Gynecol Endocrinol, 33(2):164–7.
• 14. Derakhshan M, Derakhshan M, Hedayat P, Shiasi M, Sadeghi E. (2018) Vitamin D deficiency may be a modifiable risk factor in women with endometriosis. Crescent J Med Biol Sci, 5(4):292–6.
• 15. Qiu Y, Yuan S, Wang H. (2020) Vitamin D status in endometriosis: a systematic review and meta-analysis. Arch Gynecol Obstet,302(1):141–52.
• 16. Tanni SE, Patino CM, Ferreira JC. (2020) Correlation vs. regression in association studies TT - Correlação vs. regressão em estudos de associação. J Bras Pneumol,46(1):e20200030.
• 17. Garavaglia E, Sala C, Taccagni G, Traglia M, Barbieri C, Ferrari S, et al. (2017) Fertility Preservation in Endometriosis Patients: Anti-Müllerian Hormone Is a Reliable Marker of the Ovarian Follicle Density. Front Surg,25; 4:40.
• 18. Al-Fozan H, Tulandi T. (2003) Left lateral predisposition of endometriosis and endometrioma. Obstet Gynecol,101(1):164–6.