Yeni rutenyum-azol komplekslerinin sentezi ve antioksidan özellikleri

Yıl 2017, Cilt: 21 Sayı: 6, 1121 - 1126, 01.12.2017

Neslihan Şahin , Serap Şahin Bölükbaşı

https://doi.org/10.16984/saufenbilder.338219

Cited By: 1

Öz

Bu çalışmada,
iki yeni dikloro-(1-alkilimidazolin)-(p-simen)rutenyum(II),
3 ve dikloro-(1-alkilbenzimidazol)-(p-simen)rutenyum(II), 4 kompleksi sentezlendi ve yapıları spektroskopik
tekniklerle karakterize edildi. Bu yeni metal komplekslerin in vitro antioksidan aktiviteleri; 2,2-difenil-1-pikrilhidrazil
(DPPH), hidroksil (^•OH) ve süperoksit  (O₂^-.) radikallerini inhibe etme özellikleri ile araştırıldı. Ayrıca
her bir metal kompleksinin toplam antioksidan aktivitesi de saptandı. 3
Numaralı kompleksin DPPH, hidroksil ve süperoksit radikallerini süpürme aktivitelerinin
ve toplam antioksidan aktivitesinin 4 numaralı kompleksten daha etkili olduğu bulundu.

Anahtar Kelimeler

İmidazolin; Benzimidazol; Rutenyum; DPPH; Hidroksil radikali; Süperoksit radikali; Antioksidan Aktivite

Synthesis of novel ruthenium-azole complexes and antioxidant properties

Öz

In this study, two novel dichloro-(1-alkylimidazoline)-(p-cymene)ruthenium(II), 3 and dichloro-(1-alkylbenzimidazole)-(p-cymene)ruthenium(II), 4 complexes have been synthesized and characterized
by spectroscopic
techniques. In vitro antioxidant
activities of new metal complexes have been investigated by inhibition properties
of 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl (^•OH) and superoxide (O₂^-.) radicals.
Additionally, total antioxidant activity of each metal
complexes was also determined. It was found that total antioxidant activity and
DPPH, hydroxyl and superoxide radicals scavenging
activities of compound 3 are more
efficient than compound 4.

 

 

Anahtar Kelimeler

Imidazoline; Benzimidazole; Ruthenium; DPPH; Hydroxyl Radical; Superoxide Radical; Antioxidant Activity

Kaynakça

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