Investigation of Gamma Irradiated Carvedilol Drug by EPR Technique at 295 Kelvin

Year 2018, Volume: 13 Issue: 2, 83 - 89, 30.11.2018

Yunus Emre Osmanoğlu

https://doi.org/10.29233/sdufeffd.453762

Abstract

This study aims to investigate free radicals produced after gamma irradiation of
carvedilol, the drug used in the treatment of cardiovascular, at 295 Kelvin. While unirradiated
powder samples of carvedilol do not exhibit any EPR signal, irradiated samples exhibited a
sharp and clear EPR signal. After the irradiation of the samples with gamma rays, EPR signal
intensities were increased significantly based on the irradiation dose. Mathematical functions
and correlation coefficients were calculated determining the relation between the increasing
radiation doses on the signal intensities of the sample. The results were found to be in good
agreement with the existing literature data.

Keywords

Electron paramagnetic resonance, Free radicals, Gamma irradiation

Gama ile Işınlanmış Karvedilol İlacının EPR Tekniği ile 295 Kelvinde İncelenmesi

Abstract

Bu çalışmada kardiovasküler tedavisinde kullanılan karvedilol ilacının gama ile
ışınlanmasının ardından yapısında oluşan serbest radikaller 295 Kelvin sıcaklıkta incelendi.
Işınlanmamış toz halindeki karvedilol örneğinde herhangi bir EPR sinyali gözlenmezken,
ışınlanmış örneklerin belirgin sinyaller sergiledikleri gözlendi. Işınlanmış örneklerde, ışınlama
dozuna bağlı olarak EPR sinyallerinin belirgin artışı gerçekleşti. Örneğin artan radyasyon
dozuna bağlı sinyal şiddetindeki artışı tanımlayan matematiksel denklemler ve korelasyon
katsayıları hesaplandı. Sonuçların mevcut literatür verileri ile uyum içinde olduğu tespit edildi.

Keywords

Elektron paramanyetik rezonans, Serbest radikal, Gama ışınlama

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