Nöroinflamasyonun Epileptogenezdeki Rolü ve Antiepileptojenik Tedavide Nöroinflamasyona Yönelik Hedefler

Yıl 2018, Cilt: 9 Sayı: 2, 130 - 135, 01.08.2018

Erkan Aksöz

https://doi.org/10.22312/sdusbed.421087

Öz

Özet

Deneysel epilepsi
modellerinde ve epilepsi hastalarında yapılan klinik çalışmalar sonucunda,
nöroinflamasyonun epilepsi patofizyolojisinde etkin bir rolü olduğuna dair
önemli kanıtlar elde edilmiştir. 
Özellikle, nöroinflamasyonla ilişkili yolaklar ve mediyatörlerin
epileptogenez sürecindeki etkisi yoğun araştırma konusu olmuş,
antiepileptojenik tedavilerin ve epileptojenik biyobelirteçlerin geliştirilebilmesi
için bu süreçlerin aydınlatılması önem kazanmıştır. Bu çalışmalar sonucunda
birçok patofizyolojik süreç incelenmiş ve antiepileptojenik tedavi hedefleri
tanımlanmıştır. Bu derlemede epileptogenez sürecinde nöroinflamasyon ile
ilişkili başlıca mekanizmalar ele alınmış, antiepileptojenik tedavi
geliştirilmesi  odaklı olarak potansiyel
hedefler gözden geçirilmiştir.

Abstract

Research in experimental epilepsy
models and clinical investigations on epilepsy patients have provided important
evidence that neuroinflammation has an effective role in epilepsy
pathophysiology. Particularly, the effects of neuroinflammation-related
pathways and mediators in the epileptogenesis process have been the subject of
intensive research, and the elucidation of these processes has become important
for the development of antiepileptogenic therapies and epileptogenic
biomarkers. As a result of these studies, many pathophysiological processes
have been determined and antiepileptogenic therapeutic targets have been
defined. In this review, the main mechanisms involved in neuroinflammation in
the epileptogenesis process are addressed and potential targets are reviewed
focusing on developing antiepileptogenic therapy.

Anahtar Kelimeler

Nöroinflamasyon, Epileptogenez, Epilepsi, Antiepileptojenik

Kaynakça

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