Ailesel Akdeniz Ateşi

Yıl 2011, Cilt: 18 Sayı: 4, 139 - 143, 30.12.2011

Yunus Ugan , Fatih Ermiş

Öz

Ailesel Akdeniz Ateşi tekrarlayan ateş ve serozit ataklarıyla karakterize otozomal resesif geçişli otoinflamatuar bir hastalıktır. Hastalığa 16. kromozomun kısa kolunda yer alan ve MEFV olarak isimlendirilen genin neden olduğu bilinmektedir. Bugüne kadar 150'den fazla gen mutasyonu tanımlanmış olmasına rağmen hastalığın tanısı halen klinik olarak konulmaktadır. Hastalığın en önemli ve prognozu belirleyen komplikasyonu amiloidozdur. Hem amiloidoz gelişimini engelleyen hem de atak şiddeti ve sıklığını azaltan tek tedavi ajanı kolşisindir. Bu derlemede, bu tarihi hastalıkla ilgili en son bilgileri gözden geçirmeyi amaçladık.

Anahtar Kelimeler

Ailesel Akdeniz Ateþi, Ateþ, Kolþisin, Amiloidoz

Kaynakça

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