Resveratrol ve Etkileri Üzerine Bir Gözden Geçirme

Kemal Ergin; Aslı Yaylalı

doi:10.17343/sdutfd.94607

-

Year 2013, Volume: 20 Issue: 3, 115 - 120, 30.09.2013

Kemal Ergin , Aslı Yaylalı

Abstract

A review about resveratrol and its effectsResveratrol is a natural polyphenolic compound that found in grape, red wine, peanut, grape leaf, carob andblue berry. The first studies with resveratrol was started at 1976 by the scientists Langcake and Pryce atgrape leaves. It is known that resveratrol, that have highligted antioxidant properties and its related celldeath. Despite the French society consume foods rich of fat and cholesterol, the rate of cardiovascular diseasein French society is rather low. It is thought that this protective effect occur through intake of resveratrolin red wine and this event is called French paradox. Moreover, it is found that resveratrol inhibited thecellular events associated with carsinogenesis. The studies of the effects of physiological and pathologicalconditions and the possible protective effects of diseases through resveratrol stil continues. In this paper,resveratrols some effects in the body and some protective effect on the tissues has been taken

Keywords

Resveratrol, diabetes mellitus, antioxidant, carsinogenesis, apoptosis

References

www.sigmaaldrich.com/catalog/ 21.12.2009
Signorelli P, Ghidoni R. Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. J Nutritional Biochem 2005; 16(8):449-466
Soleas GJ, Diamandis EP, Goldberg DM. Wine as a biological fluid: history, production, and role in disease prevention. J Clin Lab Anal. 1997;11(5):287-313.
Pervaiz S, Resveratrol: from grapevines to mammalian biology. FASEB J. 2003; 17(14):1975-85.
http://web.med.harvard.edu/sites/RELEASES/html/11_1Sinclair.html
Hung LM, Chen JK, Huang SS, Lee RS, Su MJ. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovasc Res. 2000 Aug 18;47(3):549-55.
Fremont L, Belguendouz L, Delpal S. Antioxidant activity of resveratrol and alcoholfree wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci. 1999;64 (26): 2511-21.
Bertelli AA, Giovannini L, Giannessi D, Migliori M, Bernini W, Fregoni M, BertelliA. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React. 1995;17(1):1-3.
German JB, Walzem RL. The health benefits of wine. Annu Rev Nutr, 2000; 20:561-93.
Falchetti R, Fuggetta MP, Lanzilli G, Tricarico M, Ravagnan G. Effects of resveratrol on human immune cell function. Life Sci. 2001, 21;70 (1):81-96
Walle T., Hsieh, F., Delegge, M.H., Oatis, J.E. Jr., Walle, UK. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos, 2004,32(12):1377-1382.
Goldberg, D.M., Yan, J., Soleas, G.J., Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin Biochem., 2003, 36(1):79-87.
Meng, X., Maliakal, P., Lu, H., Lee, M.J., Yang, C.S., Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice. J Agric Food Chem., 2004, 52(4):935-942.
Bertelli AA, Giovannini L, Stradi R, Bertelli A, Tillement JP. Plasma, urine and tissue levels of trans- and cis-resveratrol (3,4',5-trihydroxystilbene) after short-term or prolonged administration of red wine to rats. Int J Tissue React. 1996;18(2-3): 67-71.
Aumont V, Krisa S, Battaglia E, Netter P, Richard T, Merillon JM, Magdalou J, Sabolovic N. Regioselective and stereospecific glucuronidation of trans- and cis- resveratrol in human. Arch Biochem Biophys. 2001 Sep 15;393(2):281-9.
Moynihan KA, , Plueger MM, Bernal-Mizrachi E, Ford E, Cras-Méneur C, Permutt MA, Imai S. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. 2005 Aug;2(2):105-17.
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Kim JK, Fillmore JJ, Sunshine MJ, Albrecht B, Higashimori T, Kim DW, Liu ZX, Soos TJ, Cline
W, O'Brien WR, Littman DR, Shulman GI, PKCtheta knockout mice are protected from fat-induced insulin resistance, J. Clin. Invest. 2004, 114: 823827.
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Chan, W.H. Effect of resveratrol on high glucose- induced stress in human leukemia K562 cells, J. Cell. Biochem. 2005, 94: 12671279.
Frankel EN, Waterhouse AL, Kinsella JE. Inhibition of human LDL oxidation by resveratrol. The Lancet, 1993, 341 (8852):1103-1104.
Wang Q, Xu J, Rottinghaus GE, Simonyi A, Lubahn D, Sun GY, Sun AY. Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Res. 2002, 27; 958(2): 439-47.
Giovannini L, Migliori M, Longoni BM, Das DK, Bertelli AA, Panichi V, Filippi C, Bertelli A, Resveratrol, a polyphenol found in wine, reduces ischemia reperfusion injury in rat kidneys, J. Cardiovasc. Pharmacol 2001; 37:262270.
Naderali EK, Doyle PJ, Williams G. Resveratrol induces vasorelaxation of mesenteric and uterine arteries from female guinea-pigs. Clin. Sci. (Lond.) 2000; 98(5):537- 43.
Ray PS, Maulik G, Cordis GA, Bertelli AA, Bertelli A, Das DK. The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury, Free Radic. Biol. Med 1999 (27):160 169.
Hung LM, Chen JK, Huang SS, Lee RS, Su MJ. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovasc Res. 2000, 18;47(3):549-55.
Huang SS, Tsai MC, Chih CL, Hung LM, Tsai SK. Resveratrol reduction of infarct size in Long-Evans rats subjected to focal cerebral ischemia. Life Sci. 2001, 20;69(9):1057-65.
Olas B, Wachowicz B, Szewczuk J, Saluk-Juszczak J, Kaca W. The effect of resveratrol on the platelet secretory process induced by endotoxin and thrombin. Microbios. 2001;105(410):7-13.
Burkitt MJ, Duncan J. Effects of trans-resveratrol on copper-dependent hydroxylradical formation and DNA damage: evidence for hydroxyl-radical scavenging and a novel, glu-tathione-sparing mechanism of action. Arch Biochem Biophys. 2000, 15;381(2):253-63.
Murcia MA, Martinez-Tome M. Antioxidant activity of resveratrol compared with common food additives. J Food Prot. 2001;64(3):379-84.
Kopp P. Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the French paradox? Eur J Endocrinol, 1998; 138: 619620.
Pace-Asciak CR, Hahn S, Diamandis EP, Soleas G, Goldberg DM. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: Implications for protection against coronary heart disease. Clin. Chim. Acta 1995; 235:207- 219.
Bertelli AA, Das DK. Grapes, wines, resveratrol, and heart health. J Cardiovasc Pharmacol. 2009 Dec;54(6):468-76.
Das DK, Maulik N. Resveratrol in cardioprotection. A therapeutic promise of alternative medicine. Mol Interv. 2006;6:36-47.
Das S, Das DK. Anti-inflammatory responses of resveratrol. Inflamm Allergy Drug Targets. 2007;6:168- 173.
Mukherjee S, Das DK. Resveratrol, a polyphenolic antioxidant, present in grape skin, is dose dependent in providing health benefit. Dose Response 2010;8(4):478-500
Chander V, Tirkey N, Chopra K. Resveratrol, a polyphenolic phytoalexin protects against cyclosporine- induced nephrotoxicity through nitric oxide dependent mechanism. Toxicology, 2005 210:5564
Morales AI, Buitrago JM, Santiago JM, Fernandez- Tagarro M, Lopez-Novoa JM, Perez-Barriocanal F. Protective effect of transresveratrol on gentamicin- induced nephrotoxicity. Antioxid Redox Signal, 2002; 4:893898
Nihei T, Miura Y, Yagasaki K. Inhibitory effect of resveratrol on proteinuria, hypoalbuminemia and hyperlipidemia in nephritic rats. Life Science, 2001; 68: 28452852.
Stiaccini G, Mannari C, Bertelli AAE, Giovannini L. Resveratrol-poor Red Wines Modulate SIRT1 in Human Renal Cells. Plant Foods Hum Nutr (2012) 67:289293.
Wu L, Zhang Y, Ma X, Zhang N, Qin G. The effect of resveratrol on FoxO1 expression in kidneys of diabetic nephropathy rats. Mol Biol Rep (2012) 39:90859093
Chun YJ, Kim MY, Geungerich FP. Resveratrol Is a Selective Human Cytochrome P450 1A1 Inhibitor Biochem. Biophys. Res. Commun 1999; 262:20-24.
Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HHS, Farnsworth NR, Kinghorn AD, Metha RG, Moon RC, Pezzuto JM. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes Science 1997; 275:218- 220.
Igura K, Ohta T, Kuroda Y, Kaji K. Resveratrol and quercetin inhibit angiogenesis in vitro. Cancer Lett. 2001, 28;171(1):11-6.
Lanzilli G, Fuggetta MP, Tricarico M, Cottarelli A, Serafino A, Falchetti R, Ravagnan G, Turriziani M, Adamo R, Franzese O, Bonmassar E. Resveratrol down-regulates the growth and telomerase activity of breast cancer cells in vitro. Int J Oncol. 2006;28(3):641- 8.
Schneider Y, Vincent F, Duranton B, Badolo L, Gosse F, Bergmann C, Seiler N, Raul F. Antiproliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells. Cancer Lett 2000;159:85-91.
Mitchell SH, Zhu W, Young CY. Resveratrol inhibits the expression and function of the androgen
receptor in LNCaP prostate cancer cells. Cancer Res 1999; 59:5892-5.
Damianaki A, Bakogeorgou E, Kampa M, Notas G, Hatzoglou A, Panagiotou S, Gemetzi C,
Kouroumalis E, Martin PM, Castanas E. Potent inhibitory action of red wine polyphenols on
human breast cancer cells. J Cell Biochem 2000; 78:429-41
Wieder T, Prokop A, Bagci B, Essmann F, Bernicke D, Schulze-Osthoff K, Dörken B, Schmalz
HG, Daniel PT, Henze G. Piceatannol, a hydroxylated analog of the chemopreven tive agent
resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary,
leukemic lymphoblasts.Leukemia. 2001;15(11):1735- 42.
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Resveratrol ve Etkileri Üzerine Bir Gözden Geçirme

Year 2013, Volume: 20 Issue: 3, 115 - 120, 30.09.2013

Kemal Ergin , Aslı Yaylalı

Abstract

Resveratrol üzüm, kırmızı şarap, yer fıstığı, asma yaprağı, keçi kulağı ve yabanmersininde bulunan doğal polifenolik bir bileşiktir. Resveratrolle ilgili ilk çalışmalar 1976'da Langcake ve Pryce adlı araştırmacılar tarafından asma yaprağında başlamıştır. Antioksidan özellikleri ön plana çıkan resveratrolun lipid peroksidasyonunu ve buna bağlı hücre ölümünü önlediği bilinmektedir. Fransız toplumu yağ ve kolesterol bakımından zengin gıdalar tüketmesine rağmen kalp ve damar hastalıkları oranı Fransız toplumunda oldukça düşüktür. Bu koruyucu etkinin kırmızı şaraptaki resveratrol alımı sayesinde oluştuğu düşünülmekte ve bu durum, "Fransız Paradoksu" olarak adlandırılmaktadır. Bununla birlikte resveratrolün karsinogenezis ile ilişkili hücresel olayları inhibe ettiği bulunmuştur. Resveratrolün fizyolojik ve patolojik durumlardaki etkileri ve hastalıklardaki olası koruyucu etkileri konusunda çalışmalar halen sürmektedir. Bu yazıda resveratrolün vücuttaki etkilerinden ve dokular üzerindeki koruyucu etkilerinden bazıları ele alınmıştır.

Keywords

Resveratrol, diyabetes mellitus, antioksidan, karsinogenezis, apoptozis

References

www.sigmaaldrich.com/catalog/ 21.12.2009
Signorelli P, Ghidoni R. Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. J Nutritional Biochem 2005; 16(8):449-466
Soleas GJ, Diamandis EP, Goldberg DM. Wine as a biological fluid: history, production, and role in disease prevention. J Clin Lab Anal. 1997;11(5):287-313.
Pervaiz S, Resveratrol: from grapevines to mammalian biology. FASEB J. 2003; 17(14):1975-85.
http://web.med.harvard.edu/sites/RELEASES/html/11_1Sinclair.html
Hung LM, Chen JK, Huang SS, Lee RS, Su MJ. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovasc Res. 2000 Aug 18;47(3):549-55.
Fremont L, Belguendouz L, Delpal S. Antioxidant activity of resveratrol and alcoholfree wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci. 1999;64 (26): 2511-21.
Bertelli AA, Giovannini L, Giannessi D, Migliori M, Bernini W, Fregoni M, BertelliA. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React. 1995;17(1):1-3.
German JB, Walzem RL. The health benefits of wine. Annu Rev Nutr, 2000; 20:561-93.
Falchetti R, Fuggetta MP, Lanzilli G, Tricarico M, Ravagnan G. Effects of resveratrol on human immune cell function. Life Sci. 2001, 21;70 (1):81-96
Walle T., Hsieh, F., Delegge, M.H., Oatis, J.E. Jr., Walle, UK. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos, 2004,32(12):1377-1382.
Goldberg, D.M., Yan, J., Soleas, G.J., Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin Biochem., 2003, 36(1):79-87.
Meng, X., Maliakal, P., Lu, H., Lee, M.J., Yang, C.S., Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice. J Agric Food Chem., 2004, 52(4):935-942.
Bertelli AA, Giovannini L, Stradi R, Bertelli A, Tillement JP. Plasma, urine and tissue levels of trans- and cis-resveratrol (3,4',5-trihydroxystilbene) after short-term or prolonged administration of red wine to rats. Int J Tissue React. 1996;18(2-3): 67-71.
Aumont V, Krisa S, Battaglia E, Netter P, Richard T, Merillon JM, Magdalou J, Sabolovic N. Regioselective and stereospecific glucuronidation of trans- and cis- resveratrol in human. Arch Biochem Biophys. 2001 Sep 15;393(2):281-9.
Moynihan KA, , Plueger MM, Bernal-Mizrachi E, Ford E, Cras-Méneur C, Permutt MA, Imai S. Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice. 2005 Aug;2(2):105-17.
Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, et al. Small molecule activators of SIRT 1 as therapeutics for the treatment of type 2 diabetes. Nature 2007; 450: 712-6
Kumar V, Abbas AK, Fausto N, Mitchell RN, Robbins Temel Patoloji, 8.baský, Saunders Elseviers, syf. 28, 2007.
Tevfik N, Ragýp B, Ufuk K. Diyabetik Sýçanlarda insülinle kombine edilmiþ A, E, ve C vitamini tedavisinin antioksidan enzimler üzerine etkileri. Türk Klinik Biyokimya Derg 2004; 2(3): 113-119
Cai, D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE. Local and systemic insulin resistance resulting from hepatic activation of IKK- beta and NF-kappaB, Nat. Med., 2005, 11:183190.
Kim JK, Fillmore JJ, Sunshine MJ, Albrecht B, Higashimori T, Kim DW, Liu ZX, Soos TJ, Cline
W, O'Brien WR, Littman DR, Shulman GI, PKCtheta knockout mice are protected from fat-induced insulin resistance, J. Clin. Invest. 2004, 114: 823827.
Seda Y.A., Menevþe Sevda, Alp Ebru, Helvacýoðlu Fatma The effects of resveratrol on COX-1 and COX- 2 mRNA and protein levels in diabetic rat kidneys Mol. Biol. Rep. 10. 1007/s 11033-009-9737-6 ////2009
Chan, W.H. Effect of resveratrol on high glucose- induced stress in human leukemia K562 cells, J. Cell. Biochem. 2005, 94: 12671279.
Frankel EN, Waterhouse AL, Kinsella JE. Inhibition of human LDL oxidation by resveratrol. The Lancet, 1993, 341 (8852):1103-1104.
Wang Q, Xu J, Rottinghaus GE, Simonyi A, Lubahn D, Sun GY, Sun AY. Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Res. 2002, 27; 958(2): 439-47.
Giovannini L, Migliori M, Longoni BM, Das DK, Bertelli AA, Panichi V, Filippi C, Bertelli A, Resveratrol, a polyphenol found in wine, reduces ischemia reperfusion injury in rat kidneys, J. Cardiovasc. Pharmacol 2001; 37:262270.
Naderali EK, Doyle PJ, Williams G. Resveratrol induces vasorelaxation of mesenteric and uterine arteries from female guinea-pigs. Clin. Sci. (Lond.) 2000; 98(5):537- 43.
Ray PS, Maulik G, Cordis GA, Bertelli AA, Bertelli A, Das DK. The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury, Free Radic. Biol. Med 1999 (27):160 169.
Hung LM, Chen JK, Huang SS, Lee RS, Su MJ. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovasc Res. 2000, 18;47(3):549-55.
Huang SS, Tsai MC, Chih CL, Hung LM, Tsai SK. Resveratrol reduction of infarct size in Long-Evans rats subjected to focal cerebral ischemia. Life Sci. 2001, 20;69(9):1057-65.
Olas B, Wachowicz B, Szewczuk J, Saluk-Juszczak J, Kaca W. The effect of resveratrol on the platelet secretory process induced by endotoxin and thrombin. Microbios. 2001;105(410):7-13.
Burkitt MJ, Duncan J. Effects of trans-resveratrol on copper-dependent hydroxylradical formation and DNA damage: evidence for hydroxyl-radical scavenging and a novel, glu-tathione-sparing mechanism of action. Arch Biochem Biophys. 2000, 15;381(2):253-63.
Murcia MA, Martinez-Tome M. Antioxidant activity of resveratrol compared with common food additives. J Food Prot. 2001;64(3):379-84.
Kopp P. Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the French paradox? Eur J Endocrinol, 1998; 138: 619620.
Pace-Asciak CR, Hahn S, Diamandis EP, Soleas G, Goldberg DM. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: Implications for protection against coronary heart disease. Clin. Chim. Acta 1995; 235:207- 219.
Bertelli AA, Das DK. Grapes, wines, resveratrol, and heart health. J Cardiovasc Pharmacol. 2009 Dec;54(6):468-76.
Das DK, Maulik N. Resveratrol in cardioprotection. A therapeutic promise of alternative medicine. Mol Interv. 2006;6:36-47.
Das S, Das DK. Anti-inflammatory responses of resveratrol. Inflamm Allergy Drug Targets. 2007;6:168- 173.
Mukherjee S, Das DK. Resveratrol, a polyphenolic antioxidant, present in grape skin, is dose dependent in providing health benefit. Dose Response 2010;8(4):478-500
Chander V, Tirkey N, Chopra K. Resveratrol, a polyphenolic phytoalexin protects against cyclosporine- induced nephrotoxicity through nitric oxide dependent mechanism. Toxicology, 2005 210:5564
Morales AI, Buitrago JM, Santiago JM, Fernandez- Tagarro M, Lopez-Novoa JM, Perez-Barriocanal F. Protective effect of transresveratrol on gentamicin- induced nephrotoxicity. Antioxid Redox Signal, 2002; 4:893898
Nihei T, Miura Y, Yagasaki K. Inhibitory effect of resveratrol on proteinuria, hypoalbuminemia and hyperlipidemia in nephritic rats. Life Science, 2001; 68: 28452852.
Stiaccini G, Mannari C, Bertelli AAE, Giovannini L. Resveratrol-poor Red Wines Modulate SIRT1 in Human Renal Cells. Plant Foods Hum Nutr (2012) 67:289293.
Wu L, Zhang Y, Ma X, Zhang N, Qin G. The effect of resveratrol on FoxO1 expression in kidneys of diabetic nephropathy rats. Mol Biol Rep (2012) 39:90859093
Chun YJ, Kim MY, Geungerich FP. Resveratrol Is a Selective Human Cytochrome P450 1A1 Inhibitor Biochem. Biophys. Res. Commun 1999; 262:20-24.
Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HHS, Farnsworth NR, Kinghorn AD, Metha RG, Moon RC, Pezzuto JM. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes Science 1997; 275:218- 220.
Igura K, Ohta T, Kuroda Y, Kaji K. Resveratrol and quercetin inhibit angiogenesis in vitro. Cancer Lett. 2001, 28;171(1):11-6.
Lanzilli G, Fuggetta MP, Tricarico M, Cottarelli A, Serafino A, Falchetti R, Ravagnan G, Turriziani M, Adamo R, Franzese O, Bonmassar E. Resveratrol down-regulates the growth and telomerase activity of breast cancer cells in vitro. Int J Oncol. 2006;28(3):641- 8.
Schneider Y, Vincent F, Duranton B, Badolo L, Gosse F, Bergmann C, Seiler N, Raul F. Antiproliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells. Cancer Lett 2000;159:85-91.
Mitchell SH, Zhu W, Young CY. Resveratrol inhibits the expression and function of the androgen
receptor in LNCaP prostate cancer cells. Cancer Res 1999; 59:5892-5.
Damianaki A, Bakogeorgou E, Kampa M, Notas G, Hatzoglou A, Panagiotou S, Gemetzi C,
Kouroumalis E, Martin PM, Castanas E. Potent inhibitory action of red wine polyphenols on
human breast cancer cells. J Cell Biochem 2000; 78:429-41
Wieder T, Prokop A, Bagci B, Essmann F, Bernicke D, Schulze-Osthoff K, Dörken B, Schmalz
HG, Daniel PT, Henze G. Piceatannol, a hydroxylated analog of the chemopreven tive agent
resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary,
leukemic lymphoblasts.Leukemia. 2001;15(11):1735- 42.
Gautam SC, Xu YX, Dumaguin M, Janakiraman N, Chapman RA. Resveratrol selectively inhibits leukemia cells: a prospective agent for ex viso bone marrow purging. Bone Marrow Transplant 2000; 25:639-45
Dorrie J, Gerauer H, Wachter Y, Zunino SJ, Resveratrol induces apoptosis by depolarizing
mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res 2001;61:4731-9
Kang JH, Park YH, Choi SW, Yang EK, Lee WJ. Resveratrol derivatives potently induce apoptosis in human promyelocytic leukemia cells. Exp Mol Med. 2003 Dec 31;35(6):467-74.
Jiang H ,Zhang,L.,Kuo,J.,Kuo,K.,Gautam,S.C.,Groc,L. Resveratrol induced apoptotic death in
human U251 glioma cells. Mol.Cancer Ther. 2005, 4(4):554-61.
Surh YJ, Hurh YJ, Kang JY, Lee E, Kong G, Lee SJ. Resveratrol, an antioxidant present in red
wine, induces apoptosis in human promyelocytic leukemia (HL-60) cells. Cancer Lett. 1999, 1;140(1-2):1-10
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Details

Primary Language	Turkish
Journal Section	Reviews
Authors	Kemal Ergin Aslı Yaylalı This is me
Publication Date	September 30, 2013
Submission Date	July 20, 2011
Published in Issue	Year 2013 Volume: 20 Issue: 3

Cite

Vancouver	Ergin K, Yaylalı A. Resveratrol ve Etkileri Üzerine Bir Gözden Geçirme. Med J SDU. 2013;20(3):115-20.

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Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi/Medical Journal of Süleyman Demirel University is licensed under Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International.