Plateletten Zengin Plazmanın Nazal Mukozada Yara İyileşmesine Etkisi

Year 2019, Volume: 26 Issue: 4, 408 - 411, 01.12.2019

Bilal Sarataş Mustafa Tüz , Mehmet Emre Sivrice , Hasan Yasan , Kemal Kürşat Bozkurt

https://doi.org/10.17343/sdutfd.482157

Cited By: 1

Abstract

Özet

Amaç: PRP nin nazal mukozada yara iyileşmesi üzerine olan etkilerini incelemek

Gereç ve yöntem: Çalışmamızda ağırlıkları 2.8-3.5 kg (ortalama 3.2 kg) ağırlığında 32 adet erkek Yeni Zelanda beyaz tavşanı kullanıldı. Sağ nazal kavitelerine girilerek interdental fırça yardımı ile (brushing technique) septum, konka ve lateral nazal duvarlarında mukozal hasar oluşturuldu. Hayvanlar birinci hafta ve üçüncü hafta olmak üzere iki gruba ve bu iki grup da kontrol ve PRP olmak üzere iki alt gruba ayrıldı.

Bulgular: Histopatolojik skorlama sonuçlarına göre birinci hafta grubunda inflamasyonun şiddeti parametresi açısından istatistiksel olarak anlamlı fark saptandı (p=0,009).Diğer parametreler açısından birinci hafta ve üçüncü hafta gruplarında istatistiksel olarak anlamlı fark saptanmadı.

Sonuçlar: Sonuçlarımız PRP nin yara iyileşmesinin erken aşamalarında inflamasyonu azalttığını göstermektedir. PRP nin nazal mukozal yara iyileşmesi üzerindeki etkilerinin anlaşılabilmesi için ileri çalışmalara ihtiyaç olduğu düşünülmektedir.

 

Keywords

plateletten zengin plazma, nazal mukoza, inflamasyon

Effects of Platelet-Rich Plasma (PRP) on Wound Healing in Nasal Mucosa

Abstract

Abstract

Objective: Study
the effects of  platelet-rich plasma (PRP) on wound healing
in nasal  mucosa.

Materials and
Methods: Thirty two adult New Zealand white rabbit of
male sex were used for this study each weighing between 2800 and 3500
grams.Mucosal damage was created by interdental brush (brushing technique). The
animals were randomly distributed into two groups as first week group and third
week group. This two groups were subdivided into two subgroups as control and
PRP.

Results:
According to the histopathologic scoring results, in first week group
statistically significant difference was observed in term of inflammation
severity between PRP and control subgroups (p =0.009). No
statistically significant difference was observed between the other groups in
terms of mucosal edema severity, loss of cilia degree between ciliary
cells,fibrosis severity, goblet cell hyperplasia, inflammation severity, congestion
and squamous metaplasia.

Conclusion: Our results show that PRP reduces inflammation in early stages of
wound healing. We believe further more studies are needed to understand the effects
of PRP on nasal  mucosal  wound healing.

Keywords

platelet-rich plasma, nasal mucosa, inflamation

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