Prognostic Evaluation of Systemic Immune Inflammation Index in Sudden Idiopathic Sensorineural Hearing Loss

Year 2020, Volume: 27 Issue: 4, 455 - 461, 25.12.2020

Yusuf Çağdaş Kumbul , Hasan Yasan , Mustafa Tüz , Erdoğan Okur , Mehmet Emre Sivrice , Bekir Büyükçelik

https://doi.org/10.17343/sdutfd.742573

Cited By: 3

Abstract

Objective: This study aimed to investigate the prognostic value of systemic immune inflammation index (SII) in sudden idiopathic sensorineural hearing loss (SISNHL).
Methods: Eighty-nine patients diagnosed with SISNHL were included in this study. SII was calculated from the complete blood count when the patients were hospitalised. The patients were treated in accordance with our routine SISNHL protocol. Hearing recovery was evaluated in accordance with Siegel’s criteria, and two main groups were created (complete and incomplete recovery groups). The control group consisted of patients who were admitted to our clinic for hearing examination. SIIs were statistically analysed amongst these three groups (control, complete recovery and incomplete recovery groups).
Results: The mean SII of the three groups significantly differed (p= 0.002). The control group significantly differed from the two other groups (complete recovery group: p= 0.023, incomplete recovery group: p= 0.048). The complete recovery group did not significantly differ from the incomplete recovery group (p= 0.950).
Conclusion: SII had no prognostic value in patients diagnosed with SISNHL. However, SIIs were significantly higher in the patient groups diagnosed with SISNHL than those in the control group. This finding supports the predictive value of SII in SISNHL. Studies with more participants are needed to demonstrate the predictive value of SII in SISNHL.

Keywords

Sudden Hearing Loss, Biomarkers, Prognosis, Aetiology, Inflammation

Supporting Institution

Yok.

Project Number

Yok.

Thanks

The authors wishes to thank Dr. Hanım Kumbul for her help with the statistical analysis.

Ani İdiyopatik Sensorinöral İşitme Kaybında Sistemik İmmün İnflamasyon İndeksinin Değerlendirilmesi

Abstract

Amaç: Bu çalışma, ani idiyopatik sensorinöral işitme kaybında (AİSNİK) sistemik immün inflamasyon indeksinin (SII) prognostik ve prediktif değerini araştırmayı hedeflemiştir.
Gereç ve Yöntem: AİSNİK tanısı almış 86 hasta çalışmaya dahil edildi. Hastalar hastaneye yatırıldığında tam kan sayımından SII hesaplandı. Hastalar rutin AİSNİK protokolümüze göre tedavi edildi. İşitmenin iyileşmesi Siegel kriterlerine göre değerlendirildi ve iki ana grup oluşturuldu (tam ve tam olmayan iyileşme grupları). Kontrol grubu işitme muayenesi için kliniğimize başvuran hastalardan oluşmaktaydı. Üç grup arasında SII'lar istatistiksel olarak analiz edildi (kontrol, tam iyileşme ve tam olmayan iyileşme grupları).
Bulgular: Üç grubun SII ortalamaları anlamlı olarak farklıydı (p = 0.002). Kontrol grubu diğer iki gruptan anlamlı olarak farklıydı (tam iyileşme grubu: p = 0.023, tam olmayan iyileşme grubu: p = 0.048). Tam iyileşme grubu ile tam olmayan iyileşme grubu arasında anlamlı fark yoktu (p = 0.950).
Sonuç: AİSNİK tanısı alan hastalarda SII'ın prognostik değeri yoktu. Bununla birlikte, SII'lar AİSNİK tanısı alan hasta gruplarında kontrol grubuna göre anlamlı olarak daha yüksekti. Bu bulgu AİSNİK'de SII'ın prediktif değerini desteklemektedir. AİSNİK'de SII'ın prediktif değerini göstermek için daha fazla katılımcının olduğu çalışmalara ihtiyaç vardır.

Keywords

Ani İşitme Kaybı, Biyomarkerlar, Prognoz, Etiyoloji, İnflamasyon

Project Number

Yok.

References

• 1. Schreiber BE, Agrup C, Haskard DO, Luxon LM. Sudden sensorineural hearing loss. Lancet 2010;375:1203–11. doi:10.1016/s0140-6736(09)62071-7.
• 2. Byl FM. Sudden hearing loss: eight years’ experience and suggested prognostic table. Laryngoscope 1984;94:647–61.
• 3. O’Malley MR, Haynes DS. Sudden hearing loss. Otolaryngol Clin North Am 2008;41(3):633-49. doi: 10.1016/j.otc.2008.01.009.
• 4. Hiramatsu M, Teranishi M, Uchida Y, Nishio N, Suzuki H, Kato K, et al. Polymorphisms in genes involved in inflammatory pathways in patients with sudden sensorineural hearing loss. J Neurogenet 2012; 26(3-4):387-96. doi: 10.3109/01677063.2011.652266.
• 5. M. Hoffman, A. Blum, R. Baruch, E. Kaplan, M. Benjamin. Leukocytes and coronary heart disease. Atherosclerosis 2004;172(1):1-6. doi: 10.1016/s0021-9150(03)00164-3.
• 6. Chen, L., Zhang, G., Zhang, Z., Wang, Y., Hu, L., Wu, J. Neutrophil-to-lymphocyte ratio predicts diagnosis and prognosis of idiopathic sudden sensorineural hearing loss: a systematic review and meta-analysis. Medicine 2018; 97(38):e12492. doi: 10.1097/MD.0000000000012492.
• 7. Hu B, Yang XR, Xu Y, Sun YF, Sun C, Guo W, et al. Systemic immuneinflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014; 20(23):6212-22. doi: 10.1158/1078-0432.CCR-14-0442.
• 8. Geng Y, Shao Y, Zhu D, Zheng X, Zhou Q, Zhou W, et al. Systemic Immune-Inflammation Index Predicts Prognosis of Patients with Esophageal Squamous Cell Carcinoma: A Propensity Score-matched Analysis. Sci Rep 2016;6:39482. doi: 10.1038/srep39482.
• 9. Jiang W, Chen Y, Huang J, Xi D, Chen J, Shao Y, et al. Systemic immune-inflammation index predicts the clinical outcome in patients with nasopharyngeal carcinoma: a propensity score-matched analysis. Oncotarget 2017; 8(39):66075-86. doi: 10.18632/oncotarget.19796.
• 10. Eltohami YI, Kao HK, Lao WW, Huang Y, Abdelrahman M, Liao CT, et al. The Prediction Value of the Systemic Inflammation Score for Oral Cavity Squamous Cell Carcinoma. Otolaryngol Head Neck Surg 2018; 158(6):1042-50. doi: 10.1177/0194599817751678.
• 11. L. Siegel. The treatment of idiopathic sudden sensorineural hearing loss. Otolaryngol Clin North Am 1975; 8(2):467-73.
• 12. Pecorari G, Riva G, Naqe N, Bruno G, Nardo M, Albera R. Long-term Audiometric Outcomes in Unilateral Sudden Sensorineural Hearing Loss without Recurrence. J Int Adv Otol 2019; 15(1):56-61. doi: 10.5152/iao.2019.6670.
• 13. Huafeng Y, Hongqin W, Wenna Z, Yuan L, Peng X. Clinical characteristics and prognosis of elderly patients with idiopathic sudden sensorineural hearing loss. Acta Otolaryngol 2019; 139(10):866-9. doi: 10.1080/00016489.2019.1641218.
• 14. Zhang Y, Jiang Q, Wu X, Xie S, Feng Y, Sun H. The Influence of Metabolic Syndrome on the Prognosis of Idiopathic Sudden Sensorineural Hearing Loss. Otol Neurotol 2019;40(8):994-7. doi: 10.1097/MAO.0000000000002352.
• 15. Chen C, Wang M, Wang H, Xiong W, Dai Q, Wang B, et al. Impact of hyperlipidemia as a coexisting factor on the prognosis of idiopathic sudden sensorineural hearing loss: A propensity score matching analysis.Clin Otolaryngol 2020; 45(1):2-11. doi: 10.1111/coa.13421.
• 16. Toroslu T, Erdoğan H, Çağlar Ö, Güçlü O, Dereköy FS. Comparison of Different Treatment Methods for Idiopathic Sudden Sensorineural Hearing Loss. Turk Arch Otorhinolaryngol 2018;56(4):226-32. doi: 10.5152/tao.2017.2337.
• 17. Chung JH, Cho SH, Jeong JH, Park CW, Lee SH. Multivariate analysis of prognostic factors for idiopathic sudden sensorineural hearing loss in children. Laryngoscope 2015;125(9):2209-15. doi: 10.1002/lary.25196.
• 18. Fest J, Ruiter R, Mulder M, Groot Koerkamp B, Ikram MA, Stricker BH, et al. The systemic immune-inflammation index is associated with an increased risk of incident cancer-A population-based cohort study. Int J Cancer 2020;146(3):692-8. doi: 10.1002/ijc.32303.
• 19. Meng X, Chang Q, Liu Y, Chen L, Wei G, Yang J, et al. Determinant roles of gender and age on SII, PLR, NLR, LMR and MLR and their reference intervals defining in Henan, China: A posteriori and big‐data‐based. J Clin Lab Anal 2018;32(2). doi: 10.1002/jcla.22228.
• 20. Deveci I, Surmeli M, Onder S, Karabulut B, Deveci HS, Oysu C. Correlation of Histopathological Findings in Laryngeal Squamous Cell Carcinoma with Inflammatory Biomarkers. ENT Updates 2019;9(1), 44-52. doi: 10.32448/entupdates.541148.
• 21. Fang H, Zhang H, Wang Z, Zhou Z, Li Y, Lu L. Systemic immune‐inflammation index acts as a novel diagnostic biomarker for postmenopausal osteoporosis and could predict the risk of osteoporotic fracture. J Clin Lab Anal 2020;34(1):e23016. doi: 10.1002/jcla.23016.
• 22. Zuo H, Xie X, Peng J, Wang L, Zhu R. Predictive Value of Novel Inflammation-Based Biomarkers for Pulmonary Hypertension in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Anal Cell Pathol (Amst). 2019:5189165. doi: 10.1155/2019/5189165.
• 23. Qiao XF, Li X, Wang GP, Bai YH, Zheng W, Li TL. Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients with Sudden Sensorineural Hearing Loss. Med Princ Pract 2019;28(1):23-7. doi: 10.1159/000494556.
• 24. Seo YJ, Jeong JH, Choi JY, Moon IS. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss. Dis Markers 2014:702807. doi: 10.1155/2014/702807.
• 25. Gary T, Pichler M, Belaj K, Hafner F, Gerger A, Froehlich H, et al. Platelet-to-lymphocyte ratio: a novel marker for critical limb ischemia in peripheral arterial occlusive disease patients. PLoS One 2013; 8(7):e67688. doi: 10.1371/journal.pone.0067688.
• 26. Moodley D, Mody GM, Chuturgoon AA. Initiation but no execution-modulation of peripheral blood lymphocyte apoptosis in rheumatoid arthritis-a potential role for heat shock protein 70. J Inflamm (Lond) 2011; 8(1):30. doi: 10.1186/1476-9255-8-30.
• 27. Demir F, Karadeniz C, Özdemir R, Yozgat Y, Çelegen K, Karaaslan U, et al. Usefulness of Neutrophil to Lymphocyte Ratio in Prediction of Coronary Artery Lesions in Patients with Kawasaki Disease Balkan Med J 2015;32(4):371-6. doi: 10.5152/balkanmedj.2015.151108.
• 28. Özler GS. Increased neutrophil-lymphocyte ratio in patients with idiopathic sudden sensorineural hearing loss. J Craniofac Surg 2014;25(3):e260-3. doi: 10.1097/SCS.0000000000000565.
• 29. Koçak HE, Elbistanlı MS, Acıpayam H, Alakras WME, Kıral MN, Kayhan FT. Are neutrophil/ lymphocyte and platelet/lymphocyte ratios related with formation of sudden hearing loss and its prognosis? Eur Ann Otorhinolaryngol Head Neck Dis 2017;134(6):383-6. doi: 10.1016/j.anorl.2016.06.005.
• 30. Ulu S, Ulu MS, Bucak A, Ahsen A, Yucedag F, Aycicek A. Neutrophil-to-lymphocyte ratio as a new, quick, and reliable indicator for predicting diagnosis and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol 2013;34(8):1400-4. doi: 10.1097/MAO.0b013e31829b57df.