YAYGIN BAZI NÖROLOJİK HASTALIKLARDA KOMORBİD PSİKİYATRİK BOZUKLUKLAR
Yıl 2022,
Cilt: 29 Sayı: 1, 75 - 83, 01.03.2022
Ümit Görgülü
,
Nermin Gürhan
,
Yasemin Yalçın Akman
,
Ülkü Polat
,
Kevser Altay
,
Şükrü Özen
,
Behçet Coşar
,
Giray Kolcu
Öz
Amaç
Bu çalışma, yaygın nörolojik hastalıklara eşlik eden
psikiyatrik hastalıkları belirlemek amacıyla yapılmıştır.
Gereç ve Yöntem
Çalışma retrospektif bir çalışmadır. 26.12.2016 -
26.12.2017 tarihleri arasında psikiyatri polikliniğinde
ayaktan tedavi gören nörolojik hastalık tanısı olan
1125 hastanın dosyaları incelendi.
Bulgular
Psikiyatri polikliniğinde ayaktan tedavi gören nöroloji
hastalarında en sık depresyon (%59.9) ve anksiyete
bozukluğu (%42.5) saptandı. Anksiyete bozukluğu
(%63.3) migrende daha yaygındı ve depresyon en
sık multiple sklerozda (%67.2) görüldü. Parkinson
hastalığında kognitif bozukluk (%11,9), uyku bozuklukları
(%10), Alzheimer hastalığı (%21,1) ve demans
(%12,6) daha sıktı.
Sonuç
Bu çalışma, psikiyatrik bozuklukların nörolojik hastalıklara
sık eşlik ettiğini desteklemektedir. Bu nedenle
nörolojik hastalıklarda yaşam kalitesini artırmak için
psikiyatrik değerlendirilmede gerekmektedir.
Kaynakça
- 1. Kulaksızoğlu IB. Nörolojik Hastalıkların Psikiyatrik Yansımaları.
http://www. itfnoroloji.org/ psikiyatrik/Psikiyatrik.htm. [Accessed
14 December 2020]
- 2. Taj R. Mlanzoor M. Psychiatric disorders in neurology. Pak J
Neurological Sci 2014;9(3):48-50.
- 3. Jefferies, K.; Owino, A.; Rickards, H.; Agrawal, N. Psychiatric
disorders in inpatients on a neurology ward: Estimate of prevalence
and usefulness of screening questionnaires. J. Neurol.
Neurosurg. Psychiatry 2007, 78, 414–416
- 4. Dale C. Hesdorffer. Comorbidity between neurological illness
and psychiatric disorders. CNS Spectrums. Neuropsychiatry
2016 Jun;21(3):230-2388
- 5. Jasper Nuyena,, Franc¸ois G. Schellevisa et all. Comorbidity
was associated with neurologic and psychiatric diseases: A general
practice-based controlled study. Journal of Clinical Epidemiology:
59, 2006, nr. 12, p. 1274-1284
- 6. Kim J, Kim Y, Bae JS, Lee JH, Song HK. Concomitant Psychiatric
Symptoms in Neurological Outpatients. Int J Environ Res
Public Health 2019;16(5):860.
- 7. Menculini G, Chipi E, Paoletti P. E., Gaetani L, Nigro P, Simoni
S, Mancini A. et all. Insights into the Pathophysiology of Psychiatric
Symptoms in Central Nervous System Disorders: Implications
for Early athe nd Differential Diagnosis. Int J Mol Sci.
2021 Apr 23;22(9):4440
- 8. Bridges, K.W.; Goldberg, D.P. Psychiatric illness in inpatients
with neurological disorders: Patients’ views on discussion of
emotional problems with neurologists. Br. Med. J. (Clin. Res.
Ed.) 1984, 289, 656–658.
- 9. Ho, R.C.; Fu, E.H.; Chua, A.N.; Cheak, A.A.; Mak, A. Clinical
and psychosocial factors associated with depression and
anxiety in Singaporean patients with rheumatoid arthritis. Int. J.
Rheum. Dis. 2011, 14, 37–47.
- 10. Ho, R.C.; Mak, K.K.; Chua, A.N.; Ho, C.S.; Mak, A. The effect of
severity of depressive disorder on economic burden in a university
hospital in Singapore. Expert Rev. Pharm. Outcomes Res.
2013, 13, 549–559.
- 11. First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W.
Structured Clinical Interview for DSM-IV Axis I Disorders (SCID
I).1997, New York: Biometric Research Department.
- 12. Özkürkçügil, A., Aydemir, Ö., Yıldız, M., Esen Danacı, A., &
Köroglu. DSM-IV Eksen I Bozuklukları İçin Yapılandırılmıs ̧ Klinik
Görüs ̧Menin Türkçe'ye Uyarlanması ve Güvenilirlik Çalısması.
İlaç ve Tedavi dergisi 1999;12(4): 233–236.
- 13. First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. The
struc-tured clinical interview for DSM–III–R personality disorders
(SCID–II).Part I: Description.Journal of Personality disorders,
1995;9(2), 83–91
- 14. CosKunol, H., BaĞgdiken,I., Sorias, S., & Saygılı, R. SCID-II
(Türkçeversiyonu) görüşmesinin kişilik bozukluklarındaki güvenirligi.
TürkPsikoloji Dergisi 1994; 9(32): 26–29
- 15. Carson A, Ringbauer B, MacKenzie L.et al Neurological disease,
emotional disorder, and disability: they are related: a study
of 300 consecutive new referrals to a neurology outpatient department.
J Neurol Neurosurg Psychiatry 200068202–206.
- 16. Qing-Fei Zhao, Lan Tan, Hui-Fu et all. WangThe prevalence of
neuropsychiatric symptoms in Alzheimer's disease: Systematic
review and meta-analysis. Journal of Affective Disorders, 2016,
190: 264-271
- 17. Justine Orr, Charles N Bernstein, Lesley A. Graff et all. Factors
associated with perceived need for mental health care in
multiple sclerosis. Multiple Sclerosis and Related Disorders 25
(2018): 179–185
- 18. Peres M, Mercante J, Tobo PR, Kamei H, Bigal ME. Anxiety
and depression symptoms and migraine: a symptom-based approach
research. J Headache Pain 2017; 18(1): 37.
- 19. Hartoonian N, Terrill AL, Beier ML, et al. Predictors of anxiety in
multiple sclerosis. Rehabil Psychol 2015; 60(1): 91–98. https://
doi.org/10.1037/rep0000019.
- 20. Clary HMM, Snively BM, Hamberger MJ. Anxiety is common
and independently associated with clinical features of epilepsy.
Epilepsy Behav 2018;85:64–71. https://doi.org/ 10.1016/ j.ye-
beh.2018.05.024.
- 21. Sönmez İ, Mut S, Bozkurt A. Psychiatric Symptoms and Disorders
in Multiple Sclerosis: Review. Turkiye Klinikleri J Neur.
2016;11(2):46-54. doi: 10.5336/neuro.2016-51118.
- 22. Hanna M, Strober LB. Anxiety and depression in Multiple Sclerosis
(MS): Antecedents, consequences, and differential impact
on well-being and quality of life. Mult. Scler. Relat. Disord
2020;44:102261. Advance online publication. https://doi.org/
10.1016/ j.msard.2020.10226.
- 23. Lubomski M, Davis RL, Sue CM. Depression in Parkinson's
disease: perspectives from an Australian cohort. J Affect
Disord 2020;277:1038-1044. https://doi.org/ 10.1016/ j.
jad.2020.09.032.
- 24. Pekel NB, Yıldız D, Sığırlı D, Güneş A, Seferoğlu M. The Evaluation
of Depression, Anxiety Disorder and Sleep Quality in
Parkinson Disease Patients. Uludağ Üniv Tıp Fak Derg. 2017;
43(3):91-96.
- 25. Topbaş E, Eroğlu MZ, Zabun S, Güneş T, Çalışkan M. Electroconvulsive
Therapy in a Depressive Patient with Comorbid Parkinson
Disease. Cukurova Medical Journal 2014; 39(1):185-
188. https://doi.org/10.17826/cutf.26007.
- 26. Dindo LN, Recober A, Haddad R, Calarge CA. Comorbidity of
migraine, major depressive disorder, and generalized anxiety
disorder in adolescents and young adults. Int J Behav Med
2017; 24(4):528-534. doi: 10.1007/s12529-016-9620-5.
- 27. Yavuz BG, Aydinlar EI, Dikmen PP, Incesu C. Association
between somatic amplification, anxiety, depression, stress and
migraine. J Headache Pain 2013;14 (1):53.doi: 10.1186/1129-
2377-14-53.
- 28. Hung CI, Liu CY, Yang CH, Wang SJ. Migraine with active headache
was associated with other painful physical symptoms at
two-year follow-up among patients with major depressive disorder.
Plos One 2019; 14(4): e0216108. https://doi.org/ 10.1371/
journal.pone.0216108
- 29. Sah SK, Rai N, Sah MK, et al. Comorbid depression and its
associated factors in patients with epilepsy treated with single
and multiple drug therapy: A cross-sectional study from Himalayan
country. Epilepsy Behav 2020; 112:107455. https://doi.
org/10.1016/ j.yebeh.2020.107455
- 30. Kim SJ, Lee SA, Ryu HU, et al. Factors associated with obsessive-
compulsive symptoms in people with epilepsy. Epilepsy
Behav 2020; 102:106723. https://doi.org/10.1016/ j.yebeh.
2019.106723
- 31. Foroughipour M, Behdani F, Hebrani P, et al. Frequency of obsessive-
compulsive disorder in patients with multiple sclerosis:
A cross-sectional study. J Res Med Sci 2012;17(3), 248–253.
- 32. Lo Monaco MR, Di Stasio E, Zuccalà G, et al. Prevalence of Obsessive-
Compulsive Symptoms in Elderly Parkinson Disease
Patients: A Case-Control Study. Am J Geriatr Psychiatry 2020;
28(2): 167–175. https:// doi.org/ 10.1016/j.jagp.2019.08.022
- 33. Maia AF, Pinto AS, Barbosa ER, Menezes PR, Miguel EC.
Obsessive-compulsive symptoms, obsessive-compulsive
disorder, and related disorders in Parkinson's disease. J
Neuropsychiatry Clin Neurosci 2003; 15(3): 371–374. https://
doi.org/10.1176/jnp.15.3.371
- 34. Goulart AC, Santos IS, Brunoni AR, et al. Migraine headaches
and mood/anxiety disorders in the ELSA Brazil. Headache
2014;54(8):1310–1319. https://doi.org/10.1111/head.12397.
- 35. Amato MP, Prestipino E, Bellinvia A, et al. (2019). Cognitive
impairment in multiple sclerosis: An exploratory analysis
of environmental and lifestyle risk factors. Plos One, 14(10),
e0222929. https://doi.org/10.1371/journal.pone.0222929
- 36. Weil RS, Hsu JK, Darby RR, et al. Neuroimaging in Parkinson’s
disease dementia: connecting the dots. Brain Commun
2019;1(1):fcz006. doi: 10.1093/ braincomms/fcz006.
- 37. Benbir G, Karadeniz G. Parkinson Hastalığında Uyku Bozuklukları.
Parkinson Hastalığı ve Hareket Bozuklukları Dergisi
2011;14(2):59-72.
- 38. Lai YY, Hsieh KC, Nguyen D, Peever J, Siegel JM. Neurotoxic
lesions at the ventral mesopontine junction change sleep time
and muscle activity during sleep: an animal model of motor
disorders in sleep. Neuroscience 2008; 154(2):431-443. doi:
10.1016/ j. neuroscience. 2008.03.085.
- 39. Melka D, Tafesse A, Bower JH, Assefa D. Prevalence of sleep
disorders in Parkinson's disease patients in two neurology referral
hospitals in Ethiopia. BMC Neurology 2019; 19(1):205.
https://doi.org/10.1186/s12883-019-1431-2.
- 40. Sahebzadeh N, Baf MMF, Homam SM. Sleep Quality and Cognitive
Impairment in Patients with Parkinson’s disease in Iran.
Turk J Neurol 2016;22:121-6. doi:10.4274/tnd.84755.
- 41. Dharmadhikari AS, Sinha VK. Psychiatric Comorbidity in Children
with Epilepsy: A Cross-sectional 5 Years Rural Prevalence
Study. J Neurosci Rural Pract 2017; 8(2); 179–184. https://doi.
org/10.4103/jnrp.jnrp_487_16.
- 42. Chen Z, Lusicic A, O'Brien TJ, et al. Psychotic disorders induced
by antiepileptic drugs in people with epilepsy. Brain
2016;139(:2668–2678. https://doi.org/10.1093/brain/aww196.
- 43. Holmes GL. Cognitive impairment in epilepsy: the role of
network abnormalities. Epileptic Disord 2015;17(2):101–16. https://
doi.org/10.1684/epd.2015.0739.
- 44. Clancy MJ, Clarke MC, Connor DJ, Cannon, M, Cotter DR.
The prevalence of psychosis in epilepsy; a systematic review
and meta-analysis. BMC Psychiatry 2014; 14:75. https:// doi.
org/10.1186/1471-244X-14-75.
- 45. Pinckaers F, Boon ME, Majoie M. Risk factors predisposing to
psychotic symptoms during levetiracetam therapy: A retrospective
study. Epilepsy behav 2019;100(Pt A):106344. https://doi.
org/10.1016/j.yebeh.2019.05.039.
- 46. MacDonald KE, Cozza K L, Vythilingam M. Epilepsy-Related
Psychosis: A Case Report and Brief Review of Literature. Psychosomatics
2020; 61(4):400–404. https://doi.org/10.1016/
j.psym.2019.11.004.
- 47. Dravet C.Troubles comportementaux des épileptiques [The
behavioral disorders in epilepsy]. Revue neurologique 2002;
158(5 Pt 2): 4S33–4S38.
- 48. Salpekar J. Mood Disorders in Epilepsy Focus. Am Psychiatr
Publ 2016; 14(4): 465–72. doi: 10.1176/appi.focus.20160017
- 49. Alyanak B., Psychogenic Seizure, Trauma in the Developmental
Process. Arch Neuropsychiatry 2013; 50: 291-294. doi:
10.4274/npa.y6990.
- 50. Ahmadvand A, Sepehrmanesh Z, Ghoreishi FS, Afshinmajd S.
Prevalence of psychiatric disorders in the general population of
Kashan, Iran. Arch. Iran. Med 2012;15(4): 205–209.
- 51. McKenzie JA, Spielman LJ, Pointer CB, et al. Neuroinflammation
as a Common Mechanism Associated with the Modifiable
Risk Factors for Alzheimer's and Parkinson's Diseases.
Curr. Aging Sci 2017;10(3):158–176. https://doi.org/10.2174/
1874609810666 17031511 3244.
- 52. Sen A, Capelli V, Husain M. Cognition and dementia in older
patients with epilepsy. Brain 2018;141(6):1592–1608. https://
doi.org/10.1093/brain/awy022.
- 53. Subota A, Pham T, Jetté N, et al. The association between dementia
and epilepsy: A systematic review and meta-analysis. Epilepsia
2017; 58(6):962–972. https://doi.org/10.1111/ epi.13744.
- 54. Kim GH, Kim JY, Byeon JH, et al. Attention deficit hyperactivity
disorder in epileptic children. J Korean Med Sci 2012;27(10):
1229–1232. https://doi.org/10.3346/jkms .2012.27.10.1229
- 55. Wang X, Lv Y, Zhang W, Meng H. Cognitive Impairment and
Personality Traits in Epilepsy: Characterization and Risk Factor
Analysis. J Nerv Ment Dis 2018; 206(10): 794–799. https:// doi.
org/10.1097/NMD.0000000000000880.
- 56. Ayta S, Korkmaz B. Cognitive Dysfunctions in Epileptic Syndromes
Epilepsi 2014;20(Ek 1):37-45 doi: 10.5505/epilepsi.
2014.70894
- 57. Ashjazadeh N, Sahraeian A, Sabzgolin I, Asadi-Pooya AA.
Attention-deficit hyperactivity disorder in adults with epilepsy.
Epilepsy Behav 2019; 101(Pt A), 106543. https://doi.org/
10.1016/j.yebeh.2019.106543.
COMORBID PSYCHIATRIC DISORDERS IN SOME COMMON NEUROLOGICAL DISEASES
Yıl 2022,
Cilt: 29 Sayı: 1, 75 - 83, 01.03.2022
Ümit Görgülü
,
Nermin Gürhan
,
Yasemin Yalçın Akman
,
Ülkü Polat
,
Kevser Altay
,
Şükrü Özen
,
Behçet Coşar
,
Giray Kolcu
Öz
Objective
This study was conducted to determine psychiatric
diseases accompanying common neurological
diseases.
Material and Methods
The study is a retrospective study. The files of 1125
patients diagnosed with neurologic disease who were
treated as an outpatient in the psychiatry outpatient
clinic between 26.12.2016 - 26.12.2017 were
examined.
Results
The most commonly depression 59.9% and anxiety
disorder 42.5% were diagnosed in neurology patients
receiving outpatient treatment in the psychiatry
outpatient clinic. This anxiety was more common
in migraine (63.3 %) and depression was most
commonly seen in multiple sclerosis (67.2%). The
cognitive impairment (11.9%), sleep disorders (10%),
Alzheimer's disease (21.1%) and dementia (12.6%)
were more common in Parkinson disease.
Conclusion
This study supports that psychiatric disorders
frequently accompany neurological diseases.
Therefore, psychiatric evaluation is required in order
to increase the quality of life in neurological diseases.
Kaynakça
- 1. Kulaksızoğlu IB. Nörolojik Hastalıkların Psikiyatrik Yansımaları.
http://www. itfnoroloji.org/ psikiyatrik/Psikiyatrik.htm. [Accessed
14 December 2020]
- 2. Taj R. Mlanzoor M. Psychiatric disorders in neurology. Pak J
Neurological Sci 2014;9(3):48-50.
- 3. Jefferies, K.; Owino, A.; Rickards, H.; Agrawal, N. Psychiatric
disorders in inpatients on a neurology ward: Estimate of prevalence
and usefulness of screening questionnaires. J. Neurol.
Neurosurg. Psychiatry 2007, 78, 414–416
- 4. Dale C. Hesdorffer. Comorbidity between neurological illness
and psychiatric disorders. CNS Spectrums. Neuropsychiatry
2016 Jun;21(3):230-2388
- 5. Jasper Nuyena,, Franc¸ois G. Schellevisa et all. Comorbidity
was associated with neurologic and psychiatric diseases: A general
practice-based controlled study. Journal of Clinical Epidemiology:
59, 2006, nr. 12, p. 1274-1284
- 6. Kim J, Kim Y, Bae JS, Lee JH, Song HK. Concomitant Psychiatric
Symptoms in Neurological Outpatients. Int J Environ Res
Public Health 2019;16(5):860.
- 7. Menculini G, Chipi E, Paoletti P. E., Gaetani L, Nigro P, Simoni
S, Mancini A. et all. Insights into the Pathophysiology of Psychiatric
Symptoms in Central Nervous System Disorders: Implications
for Early athe nd Differential Diagnosis. Int J Mol Sci.
2021 Apr 23;22(9):4440
- 8. Bridges, K.W.; Goldberg, D.P. Psychiatric illness in inpatients
with neurological disorders: Patients’ views on discussion of
emotional problems with neurologists. Br. Med. J. (Clin. Res.
Ed.) 1984, 289, 656–658.
- 9. Ho, R.C.; Fu, E.H.; Chua, A.N.; Cheak, A.A.; Mak, A. Clinical
and psychosocial factors associated with depression and
anxiety in Singaporean patients with rheumatoid arthritis. Int. J.
Rheum. Dis. 2011, 14, 37–47.
- 10. Ho, R.C.; Mak, K.K.; Chua, A.N.; Ho, C.S.; Mak, A. The effect of
severity of depressive disorder on economic burden in a university
hospital in Singapore. Expert Rev. Pharm. Outcomes Res.
2013, 13, 549–559.
- 11. First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W.
Structured Clinical Interview for DSM-IV Axis I Disorders (SCID
I).1997, New York: Biometric Research Department.
- 12. Özkürkçügil, A., Aydemir, Ö., Yıldız, M., Esen Danacı, A., &
Köroglu. DSM-IV Eksen I Bozuklukları İçin Yapılandırılmıs ̧ Klinik
Görüs ̧Menin Türkçe'ye Uyarlanması ve Güvenilirlik Çalısması.
İlaç ve Tedavi dergisi 1999;12(4): 233–236.
- 13. First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. The
struc-tured clinical interview for DSM–III–R personality disorders
(SCID–II).Part I: Description.Journal of Personality disorders,
1995;9(2), 83–91
- 14. CosKunol, H., BaĞgdiken,I., Sorias, S., & Saygılı, R. SCID-II
(Türkçeversiyonu) görüşmesinin kişilik bozukluklarındaki güvenirligi.
TürkPsikoloji Dergisi 1994; 9(32): 26–29
- 15. Carson A, Ringbauer B, MacKenzie L.et al Neurological disease,
emotional disorder, and disability: they are related: a study
of 300 consecutive new referrals to a neurology outpatient department.
J Neurol Neurosurg Psychiatry 200068202–206.
- 16. Qing-Fei Zhao, Lan Tan, Hui-Fu et all. WangThe prevalence of
neuropsychiatric symptoms in Alzheimer's disease: Systematic
review and meta-analysis. Journal of Affective Disorders, 2016,
190: 264-271
- 17. Justine Orr, Charles N Bernstein, Lesley A. Graff et all. Factors
associated with perceived need for mental health care in
multiple sclerosis. Multiple Sclerosis and Related Disorders 25
(2018): 179–185
- 18. Peres M, Mercante J, Tobo PR, Kamei H, Bigal ME. Anxiety
and depression symptoms and migraine: a symptom-based approach
research. J Headache Pain 2017; 18(1): 37.
- 19. Hartoonian N, Terrill AL, Beier ML, et al. Predictors of anxiety in
multiple sclerosis. Rehabil Psychol 2015; 60(1): 91–98. https://
doi.org/10.1037/rep0000019.
- 20. Clary HMM, Snively BM, Hamberger MJ. Anxiety is common
and independently associated with clinical features of epilepsy.
Epilepsy Behav 2018;85:64–71. https://doi.org/ 10.1016/ j.ye-
beh.2018.05.024.
- 21. Sönmez İ, Mut S, Bozkurt A. Psychiatric Symptoms and Disorders
in Multiple Sclerosis: Review. Turkiye Klinikleri J Neur.
2016;11(2):46-54. doi: 10.5336/neuro.2016-51118.
- 22. Hanna M, Strober LB. Anxiety and depression in Multiple Sclerosis
(MS): Antecedents, consequences, and differential impact
on well-being and quality of life. Mult. Scler. Relat. Disord
2020;44:102261. Advance online publication. https://doi.org/
10.1016/ j.msard.2020.10226.
- 23. Lubomski M, Davis RL, Sue CM. Depression in Parkinson's
disease: perspectives from an Australian cohort. J Affect
Disord 2020;277:1038-1044. https://doi.org/ 10.1016/ j.
jad.2020.09.032.
- 24. Pekel NB, Yıldız D, Sığırlı D, Güneş A, Seferoğlu M. The Evaluation
of Depression, Anxiety Disorder and Sleep Quality in
Parkinson Disease Patients. Uludağ Üniv Tıp Fak Derg. 2017;
43(3):91-96.
- 25. Topbaş E, Eroğlu MZ, Zabun S, Güneş T, Çalışkan M. Electroconvulsive
Therapy in a Depressive Patient with Comorbid Parkinson
Disease. Cukurova Medical Journal 2014; 39(1):185-
188. https://doi.org/10.17826/cutf.26007.
- 26. Dindo LN, Recober A, Haddad R, Calarge CA. Comorbidity of
migraine, major depressive disorder, and generalized anxiety
disorder in adolescents and young adults. Int J Behav Med
2017; 24(4):528-534. doi: 10.1007/s12529-016-9620-5.
- 27. Yavuz BG, Aydinlar EI, Dikmen PP, Incesu C. Association
between somatic amplification, anxiety, depression, stress and
migraine. J Headache Pain 2013;14 (1):53.doi: 10.1186/1129-
2377-14-53.
- 28. Hung CI, Liu CY, Yang CH, Wang SJ. Migraine with active headache
was associated with other painful physical symptoms at
two-year follow-up among patients with major depressive disorder.
Plos One 2019; 14(4): e0216108. https://doi.org/ 10.1371/
journal.pone.0216108
- 29. Sah SK, Rai N, Sah MK, et al. Comorbid depression and its
associated factors in patients with epilepsy treated with single
and multiple drug therapy: A cross-sectional study from Himalayan
country. Epilepsy Behav 2020; 112:107455. https://doi.
org/10.1016/ j.yebeh.2020.107455
- 30. Kim SJ, Lee SA, Ryu HU, et al. Factors associated with obsessive-
compulsive symptoms in people with epilepsy. Epilepsy
Behav 2020; 102:106723. https://doi.org/10.1016/ j.yebeh.
2019.106723
- 31. Foroughipour M, Behdani F, Hebrani P, et al. Frequency of obsessive-
compulsive disorder in patients with multiple sclerosis:
A cross-sectional study. J Res Med Sci 2012;17(3), 248–253.
- 32. Lo Monaco MR, Di Stasio E, Zuccalà G, et al. Prevalence of Obsessive-
Compulsive Symptoms in Elderly Parkinson Disease
Patients: A Case-Control Study. Am J Geriatr Psychiatry 2020;
28(2): 167–175. https:// doi.org/ 10.1016/j.jagp.2019.08.022
- 33. Maia AF, Pinto AS, Barbosa ER, Menezes PR, Miguel EC.
Obsessive-compulsive symptoms, obsessive-compulsive
disorder, and related disorders in Parkinson's disease. J
Neuropsychiatry Clin Neurosci 2003; 15(3): 371–374. https://
doi.org/10.1176/jnp.15.3.371
- 34. Goulart AC, Santos IS, Brunoni AR, et al. Migraine headaches
and mood/anxiety disorders in the ELSA Brazil. Headache
2014;54(8):1310–1319. https://doi.org/10.1111/head.12397.
- 35. Amato MP, Prestipino E, Bellinvia A, et al. (2019). Cognitive
impairment in multiple sclerosis: An exploratory analysis
of environmental and lifestyle risk factors. Plos One, 14(10),
e0222929. https://doi.org/10.1371/journal.pone.0222929
- 36. Weil RS, Hsu JK, Darby RR, et al. Neuroimaging in Parkinson’s
disease dementia: connecting the dots. Brain Commun
2019;1(1):fcz006. doi: 10.1093/ braincomms/fcz006.
- 37. Benbir G, Karadeniz G. Parkinson Hastalığında Uyku Bozuklukları.
Parkinson Hastalığı ve Hareket Bozuklukları Dergisi
2011;14(2):59-72.
- 38. Lai YY, Hsieh KC, Nguyen D, Peever J, Siegel JM. Neurotoxic
lesions at the ventral mesopontine junction change sleep time
and muscle activity during sleep: an animal model of motor
disorders in sleep. Neuroscience 2008; 154(2):431-443. doi:
10.1016/ j. neuroscience. 2008.03.085.
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