ISPARTA BURDUR YÖRESİNDEKİ KOLON KANSERİ HASTALARININ DEMOGRAFİK VE KLİNİK ÖZELLİKLERİ

Yıl 2022, Cilt: 29 Sayı: 3, 386 - 389, 30.09.2022

Erkan Kayıkçıoğlu

https://doi.org/10.17343/sdutfd.1104209

Öz

Amaç
Süleyman Demirel Üniversitesi Tıbbi Onkoloji Polikliniğinde
takipli kolon kanseri hastalarının demografik
ve klinikopatolojik özelliklerini belirlemek.
Gereç ve Yöntem
2010-2021 yılları arasında Süleyman Demirel Üniversitesi
Tıp Fakültesi Tıbbi Onkoloji kliniğine başvuran
582 kolon kanseri tanısı almış olan hastanın poliklinik
arşiv dosyaları incelendi; yaş, cinsiyet, tümör yerleşim
yeri, hastaların ailevi kanser öyküsü, tanı anındaki patolojik
TNM evresi kayıt altına alındı.
Bulgular
Medyan yaş 63,5 ölçüldü. 582 hastanın 375’i (64,4%)
erkek, 207’si (35,6) kadındı. Hastaların 34’ünde
(%5,8) ailede kolon kanseri öyküsü mevcuttu.147
(%25,3) hastada tümör sağ kolondan, 168 (% 28,9)
sol kolondan, 265’inde (%45,5) ise rektumdan kaynaklanmaktaydı.
Tanı anında 35’inde(%6) T evresi T1,
61’inde (%10,5) T2, 418’inde (%71,8) T3 ve 67’sinde
(%11,5) T4 idi. Hastaların patolojik N evresi 246’sında
(%42,3) N0, 168’inde (%28,9) N1, 168’inde (%28,9)
N2 idi. TNM derecesine göre evrelendirildiğinde 82
(%14,1) hasta Evre 1, 153 (%26,3) hasta Evre 2, 242
(%41,6) hasta Evre 3, 105 (%18) hasta Evre 4 ‘de
tanı almıştır. Hastaların 106’sında (%18,2) tanı anında
metastaz saptandı.
Sonuç
Isparta Burdur yöresinden Süleyman Demirel Üniversitesi
Tıp Fakültesi Tıbbi Onkoloji Polikliniğine başvuran
hastaların çoğu ileri evrede tanı alan hastalardır.
Kolon kanseri taramaları hakkında bölge halkının bilinçlendirilmesi,
kolon kanseri farkındalığının arttırılması
hayati önem taşımaktadır.

Anahtar Kelimeler

Kolon Kanseri, Tarama, Isparta, Burdur

DEMOGRAPHIC AND CLINICAL CHARACTERISTICS OF PATIENTS WITH COLON CANCER IN ISPARTA-BURDUR REGION

Öz

Objective
To define the demographic and clinicopathological
characteristics of colon cancer patients followed up
at Suleyman Demirel University, Medical Oncology
Outpatient Clinic.
Material and Method
Outpatient archive files of 582 patients who applied
to Suleyman Demirel University Faculty of Medicine,
Medical Oncology Clinic and received a diagnosis of
colon cancer between 2010-2021 were examined and
patients’ age, gender, tumor location, family history
of cancer, and pathological TNM stage at the time of
diagnosis were recorded.
Results
Median age was 63.5 years. Of the 582 patients, 375
(64.4%) were male and 207 (35.6%) were female.
Thirty-four (5.8%) of the patients had family history
of colon cancer. The origin of the tumor was the right
colon in 147 (25.3%) patients, the left colon in 168
(28.9%), and the rectum in 265 (45.5%). At the time
of diagnosis, T stage was T1 in 35 (6%) patients,
T2 in 61 (10.5%), T3 in 418 (71.8%), and T4 in 67
(11.5%). Pathological N stage was N0 in 246 (42.3%)
patients, N1 in 168 (28.9%), and N2 in 168 (28.9%).
When staging was made according to TNM grades,
82 (14.1%) patients were diagnosed with Stage 1
disease, 153 (26.3%) with Stage 2 disease, 242
(41.6%) with Stage 3, and 105 (18%) patients were
diagnosed with Stage 4 disease. Metastasis was
detected at the time of diagnosis in 106 (18.2%) of
the patients.
Conclusion
Most of the patients who apply to Suleyman Demirel
University Faculty of Medicine, Medical Oncology
Outpatient Clinic from the Isparta-Burdur region are
patients diagnosed at an advanced stage. It is of
vital importance to raise awareness of colon cancer
screenings and increase awareness of colon cancer
in the community of this region.

Anahtar Kelimeler

Colon Cancer, Screening, Burdur, Isparta

Kaynakça

• 1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-49.
• 2. Benson AB, Venook AP, Al-Hawary MM, Cederquist L, Chen YJ, Ciombor KK, et al. NCCN Guidelines Insights: Colon Cancer, Version 2.2018. J Natl Compr Canc Netw. 2018;16(4):359- 69.
• 3. Moreno CC, Mittal PK, Sullivan PS, Rutherford R, Staley CA, Cardona K, et al. Colorectal cancer initial diagnosis: screening colonoscopy, diagnostic colonoscopy, or emergent surgery, and tumor stage and size at initial presentation. Clinical colorectal cancer. 2016;15(1):67-73.
• 4. Arnold D, Lueza B, Douillard JY, Peeters M, Lenz HJ, Venook A, et al. Prognostic and predictive value of primary tumour side in patients with RAS wild-type metastatic colorectal cancer treated with chemotherapy and EGFR directed antibodies in six randomized trials. Ann Oncol. 2017;28(8):1713-29.
• 5. Stoffel EM, Murphy CC. Epidemiology and Mechanisms of the Increasing Incidence of Colon and Rectal Cancers in Young Adults. Gastroenterology. 2020;158(2):341-53.
• 6. Petrelli F, Tomasello G, Borgonovo K, Ghidini M, Turati L, Dallera P, et al. Prognostic Survival Associated With Left-Sided vs Right-Sided Colon Cancer: A Systematic Review and Meta-analysis. JAMA Oncol. 2017;3(2):211-9.
• 7. Sinicrope FA, Mahoney MR, Yoon HH, Smyrk TC, Thibodeau SN, Goldberg RM, et al. Analysis of Molecular Markers by Anatomic Tumor Site in Stage III Colon Carcinomas from Adjuvant Chemotherapy Trial NCCTG N0147 (Alliance). Clin Cancer Res. 2015;21(23):5294-304.
• 8. Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17(6):1471-4.
• 9. Davidson KW, Barry MJ, Mangione CM, Cabana M, Caughey AB, Davis EM, et al. Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement. Jama. 2021;325(19):1965-77.
• 10. Hamilton W, Round A, Sharp D, Peters TJ. Clinical features of colorectal cancer before diagnosis: a population-based case- control study. Br J Cancer. 2005;93(4):399-405.