THE POSSIBLE ROLE OF MIR-1910-3P, MIR-4649-3P, MIR-4296, AND MIR-210 IN THE PATHOGENESIS OF ATOPIC DERMATITIS: MAY MIR-4296 PLAY CRUCIAL ROLES IN THE DEVELOPMENT OF ATOPIC DERMATITIS?

Year 2022, Volume: 29 Issue: 3, 494 - 503, 30.09.2022

Havva Hilal Ayvaz , Kuyaş Hekimler Öztürk , Emrah Atay , İjlal Erturan , Selma Korkmaz , Mehmet Yıldırım

https://doi.org/10.17343/sdutfd.1164324

Cited By: 1

Abstract

Objective
Atopic dermatitis (AD) is a chronic inflammatory skin
disease with unexplained points in its pathogenesis.
Altered expressions of microRNAs (miRNA, miR) in
plasma can serve as markers that distinguish diseased
individuals from healthy controls AD. In the present
study, plasma expression levels of miR-1910-3p, miR-
4649-3p, miR-4296 and miR-210 were investigated in
AD.
Material and Method
Forty patients with AD and forty healthy control subjects
were included in the present study. Quantitative realtime
PCR was used to measure miRNAs.
Results
The mean plasma miR-4296 level was higher in the
patient group (p < 0.001). There was a significant
negative correlation between SCORAD scores and
miR-210 levels (r:-0.340, p=0.032). miR-210 levels
decreased with increasing disease severity. In logistic
regression analyses, an increase in plasma miR-4296
levels was found to be statistically significant (OR
=5.464, p<0.001). Moreover, although not significant
in other analyzes, a decrease in the miR-1910-3p was
shown statistically significant.
Conclusion
MiRNAs are crucial in the pathogenesis of AD.
Increased miR-4296 seems to be significantly better
at discriminating AD patients from healthy individuals.

Keywords

Atopic dermatitis, miR-4296, miR-1910-3p, miR-210, SCORAD

ATOPİK DERMATİT PATOGENEZİNDE MİR-1910-3P, MİR-4649-3P, MİR-4296 VE MİR-210'UN OLASI ROLÜ: MİR-4296 ATOPİK DERMATİT GELİŞİMİNDE ÖNEMLİ ROL OYNAYABİLİR Mİ?

Abstract

Amaç
Atopik dermatit (AD), patogenezinde açıklanamayan
noktaları olan kronik inflamatuar bir deri hastalığıdır.
Plazmadaki mikroRNA'ların (miRNA, miR) değişmiş
ekspresyonları, hastalıklı bireyleri sağlıklı kontrollerden
ayıran belirteçler olarak hizmet edebilir. Bu çalışmada,
AD’li hastalarda miR-1910-3p, miR-4649-3p,
miR-4296 ve miR-210'un plazma ekspresyon düzeyleri
araştırıldı.
Gereç ve Yöntem
Bu prospektif çalışmaya 40 AD'li hasta ve 40 sağlıklı
kontrol alındı. MiRNA'ları ölçmek için real-time PCR
kullanıldı.
Bulgular
Ortalama plazma miR-4296 düzeyi hasta grupta daha
yüksek bulundu (p < 0.001). SCORAD skorları ile
miR-210 seviyeleri arasında anlamlı bir negatif korelasyon
saptandı (r:-0.340, p=0.032). miR-210 seviyeleri
hastalık şiddeti arttıkça azalmaktaydı. Lojistik regresyon
analizinde plazma miR-4296 seviyelerinde bir
artış istatistiksel olarak anlamlı bulundu (OR =5.464,
p<0.001). Diğer analizlerde anlamlı bir farklılık bulunmasa
da miR-1910-3p seviyelerinde bir azalma da istatistiksel
olarak anlamlıydı.
Sonuç
MiRNA'lar AD patogenezinde önemli rol oynamaktadırlar.
Artan miR-4296 ekspresyon seviyeleri, AD hastalarını
sağlıklı kişilerden ayırt etmede önemli ölçüde
daha iyi görünmektedir.

Keywords

Atopik dermatit, miR-4296, miR-1910-3p, miR-210, SCORAD

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