ÜRETRAL DARLIK TEDAVİSİ SONRASI GELİŞEN NÜKS ORANLARI İLE İNFLAMATUAR KAN BELİRTEÇLERİ ARASINDAKİ İLİŞKİ

Yıl 2023, Cilt: 30 Sayı: 4, 704 - 709, 30.12.2023

Osman Ergün

https://doi.org/10.17343/sdutfd.1383534

Öz

Amaç
Rutin kan tetkiklerinde çalışılan inflamatuar belirteç
ve bu belirteçlerin birbirleriyle oranları ile üretra darlığı
tedavisi sonrası gelişen nüks arasındaki ilişkiyi ortaya
koymak.
Gereç ve Yöntem
Çalışmaya internal üretrotomi operasyonu geçiren
142 hasta dahil edildi. Veriler retrospektif olarak tarandı.
Hastaların yaşları, eşlik eden komorbidite
durumları, kullandıkları tıbbi tedaviler, alışkanlıkları,
geçirdikleri cerrahi operasyonlar, işlem öncesi ve
sonrasında takiplerdeki üroflowmetre değerleri, darlık
lokalizasyonları ve uzunlukları, preoperatif ve post
operatif idrar ve kan tahlilleri kaydedildi.
Bulgular
İnternal üretrotomi operasyonu sonrası ilk bir yılda
nüks gelişme oranı %25,4 olarak tespit edildi. Ortalama
nüks süresi 8,9±1,9 aydı ve bu süre 1-12 ay
arasında değişmekteydi, ortanca nüks süresi ise 6 ay
olarak hesaplandı. Üretra darlığına neden olan etyolojik
faktörler incelendiğinde, iyatrojenik nedenlerin en
yaygın neden olduğu gözlemlendi. Nüks gelişen grup
ile gelişmeyen grup arasında lenfosit sayısı, platelet
sayısı, platelet-lenfosit oranı, red cell distribution width-
platelet oranı bakımından istatistiksel olarak anlamlı
farklar bulundu (p<0,05).
Sonuç
Platelet-lenfosit oranı ve red cell distribution width-platelet
oranı, internal üretrotomi sonrası olası nüksler
önceden tahmin etmek için kullanılabilir. Her iki parametrenin
de basit, ekonomik ve kolayca erişilebilir
olması, klinik kullanım açısından en büyük avantajlarıdır.

Anahtar Kelimeler

İnflamasyon, İnternal üretrotomi, Üretra darlığı, Nüks

CORRELATION BETWEEN INFLAMMATORY BLOOD MARKERS AND RECURRENCE RATES FOLLOWING URETHRAL STRICTURE TREATMENT

Öz

Objective
To investigate the relationship between inflammatory
markers routinely examined in blood tests and their
ratios with the development of recurrence after
urethral stricture treatment.
Material and Method
A total of 142 patients who underwent internal
urethrotomy were included in the study. Data were
retrospectively reviewed. Patient ages, comorbidity
status, medical treatments used, habits, previous
surgical procedures, pre- and post-procedural
İduroflowmetry
values, stricture locations and lengths,
and preoperative and postoperative urine and blood
test results were recorded.
Results
The recurrence rate within the first year after internal
urethrotomy was determined to be 25.4%. The mean
recurrence period was 8.9±1.9 months, ranging from
1 to 12 months, with a median recurrence period
of 6 months. When the etiological factors causing
urethral stricture were examined, iatrogenic causes
were observed to be the most common. There were
statistically significant differences in lymphocyte
count, platelet count, platelet-lymphocyte ratio, and
red cell distribution width-platelet ratio between
the group with recurrence and the group without
recurrence (p<0.05).
Conclusion
Platelet-lymphocyte ratio and red cell distribution
width-platelet ratio can be used to predict possible
recurrences after internal urethrotomy. The main
advantages of both parameters are their simplicity,
cost-effectiveness, and easy accessibility for clinical
use.

Anahtar Kelimeler

Inflammation, Internal urethrotomy, Recurrence, Urethral stricture

Kaynakça

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