Stabil Koroner Arter Rahatsızlığı Olan Hastalarda Erken Repolarizasyon Patern Varlığı ile Koroner Arter Hastalığının Ciddiyeti Arasındaki İlişki

Yıl 2019, Cilt: 9 Sayı: 1, 113 - 119, 20.03.2019

Serhat Karaman , Kayıhan Karaman , Abuzer Coşkun

https://doi.org/10.31832/smj.524970

Öz

Amaç: Erken repolarizasyon paterni (ERP) iyi huylu bir
varyant olarak kabul edilmesine rağmen, son zamanlarda yapılan çalışmalarda
hayatı tehdit eden aritmilerle ilişkili olduğu gösterilmiştir. Hayatı tehdit
eden aritmi ve koroner arter hastalığının (KAH) şiddeti arasında güçlü bir
ilişki olduğunu gösteren farklı çalışmalar vardır. Bu çalışmada ERP'li
hastalarda Gensini skoru (GS) değerlerinin ERP'siz hastalara göre daha yüksek
olup olmadığını belirlemeyi amaçladık.

Gereç
ve Yöntemler: Çalışmaya ERP'li toplam 110 hasta
ve 90 kontrol grubu alındı. Her hasta için GS hesaplandı. p< 0.05 anlamlı
kabul edildi.

Bulgular: GS, ERP’li hastalarda kontrol grubuna göre
anlamlı derecede yüksekti (19.5±20.2 ve 2.15±4.1; p <0.001). GS ile yaş
arasında anlamlı ilişki vardı (r= 0.507, p< 0.001). GS, çok değişkenli
lojistik regresyon analizinde bağımsız bir ERP belirleyicisidir (OR= 0.655,% 95
CI= 0.557-0.769, p <0.001). Ek olarak, yaş ve düşük yoğunluklu lipoprotein
kolesterolü, lineer regresyon analizinde GS ile ilişkili bağımsız öngörücülerdi
(OR= 0.370,%95 CI= 0.085-0.655, p= 0.011 ve OR= -0.094,%95 CI= (-0.176 -0.013),
sırasıyla p= 0.024).

Sonuçlar: KAH'nın ciddiyetindeki artış, ERP'nin ortaya
çıkmasına yol açan bir mekanizma olarak gösterilebilir.

Anahtar Kelimeler

Erken repolarizasyon patern; Gensini skoru; Stabil Koroner Arter Hastalığı

The Relationship Between the Presence of Early Repolarization Pattern and the Severity of Coronary Artery Disease in Patients with Stable Coronary Artery Disease

Öz

Objective:
Although early repolarization pattern (ERP) has been recognized as a benign
variant, in recent studies have shown that it is associated with
life-threatening arrhythmias. There are different studies demonstrated that
there is a strong relationship between life-threatening arrhythmias and the
severity of coronary artery disease (CAD). In this study, we aimed to determine
whether Gensini score (GS) values were higher in patients with ERP compared to
patients without ERP.

Materials
and Methods: Totally 110 patients with ERP and 90 control subjects were
enrolled to the study. GS was calculated for each patient. p values < 0.05
were considered significant.

Results:
GS was significantly higher in the ERP patients compared with the control group
(19.5±20.2 vs 2.15±4.1; p<0.001). There was significant correlation between
GS and age (r=0.507, p<0.001). GS was an independent predictor of ERP in
multivariate logistic regression analysis (OR=0.655, 95% CI=0.557-0.769,
p<0.001). In addition to, age and low-density lipoprotein cholesterol were
independent predictors associated with GS in linear regression analysis
(OR=0.370, 95% CI=0.085-0.655, p=0.011 and OR= -0.094, 95% CI= (-0.176-0.013),
p=0.024, respectively).

Conclusions:
An increase in the severity of CAD may be shown as a mechanism that leads to
the emergence of ERP.

Anahtar Kelimeler

Early repolarization pattern; Gensini score; Stable Coronary Artery Disease

Kaynakça

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