Diyetle K Vitamini Alımı Bilişsel Performansı Etkiler mi?

Yıl 2020, Cilt: 10 Sayı: 1, 162 - 170, 16.03.2020

Aysegul Ugural , Aylin Ayaz

https://doi.org/10.31832/smj.583473

Öz

K
vitamini yağda çözünen bir vitamin olup doğada filokinon (K1) ve menakinon (K2)
formlarında bulunmaktadır. Menadion (K3) formu ise sentetik analog olarak kullanılmaktadır.
K vitamini, metabolizmada K vitaminine bağımlı proteinlerin karboksilasyonundan
sorumludur. Genellikle kan koagülasyonü üzerine rolü olduğu bilinen K
vitamininin günümüzde kardiyovasküler hastalıklar, osteoporoz, vasküler
kalsifikasyon, kanser, diyabet ve glisemik kontrol ile de ilişkisi olduğu
gösterilmiştir. Son yıllarda ise beyinde miyelinizasyonun yoğun olduğu
bölgelerde Menakinon-4 (MK-4) formunda bulunduğu saptanmış ve bilişsel
performans ile bazı nörodejeneratif hastalıkların patogenezinde rol alabileceği
belirtilmiştir. Bu etkisini Gas-6 ve protein S gibi proteinler aracılığıyla
veya nöronları oksidatif stres hasarına karşı koruyarak gösterdiği
düşünülmektedir. Atriyal fibrilasyon (AF) hastalarının sıklıkla kullandığı
antikoagülanların ve K vitamini antagonisti olmayan antikoagülanların bilişsel
performans ve demans üzerine etkisi ise tartışmalıdır. Bu derleme makalede K
vitamini ve antikoagülanların bilişsel performans üzerine etkileri ele
alınmıştır.    

Anahtar Kelimeler

K vitamini, bilişsel performans, Alzheimer, antikoagülanlar

Kaynakça

• 1. Lamson DW, Plaza SM. The anticancer effects of vitamin K. Altern Med Rev 2003;8(3):303-318.
• 2. Schwalfenberg GK. Vitamins K1 and K2: the emerging group of vitamins required for human health. J Nutr Metab 2017;Article ID 6254836. http://doi.org/10.1155/2017/6254836.
• 3. Iwamoto J. Vitamin K2 therapy for postmenopausal osteoporosis. Nutrients 2014;6:1971-1980.
• 4. Siltari A, Vapaatalo H. Vascular calcification, vitamin K and warfarin therapy-possible or plausible connection?. Basic Clin Pharmacol Toxicol 2018;122(1):19-24.
• 5. Shea MK, Kritchevsky SB, Hsu FC, Nevitt M, Booth SL, Kwoh K, et al. The association between vitamin K status and knee osteoarthritis features in older adults: the health, aging and body composition study. Osteoarthritis Cartilage 2015;23(3):370-378.
• 6. Dahlberg S, Ede J, Schött U. Vitamin K and cancer. Scand J Clin Lab Invest 2017;77(8):555-567.
• 7. van Ballegooijen AJ, Beulens JW. The role of vitamin K status in cardiovascular health: evidence from observational and clinical studies. Curr Nutr Rep 2017;6:197-205.
• 8. Suna G, Ayaz A. K vitamininin kardiyovasküler sağlık üzerine etkisi: güncel yaklaşımlar. Bes Diy Derg 2017;45(1):61-69.
• 9. Alisi L, Cao R, De Angelis C, Cafolla A, Caramia F, Cartocci G, et al. The relationships between vitamin K and cognition: a review of current evidence. Front Neurol 2019;10:239. doi: 10.3389/fneur.2019.00239.
• 10. DiNicolantonio JJ, Bhutani J, O’Keefe JH. The health benefits of vitamin K. Open Heart 2015;2(1):e000300.
• 11. Alam P, Chaturvedi SK, Siddiqi MK, Rajpoot RK, Ajmal MR, Zaman M, et al. Vitamin k3 inhibits protein aggregation: implication in the treatment of amyloid diseases. Sci Rep 2016;6:26759.
• 12. El Asmar MS, Naoum JJ, Arbid EJ. Vitamin K dependent proteins and the role of vitamin K2 in the modulation of vascular calcification: a review. Oman Med 2014;29(3):172-177.
• 13. Shiraki M, Tsugawa N, Okano T. Recent advances in vitamin K-dependent Gla-containing proteins and vitamin K nutrition. Osteoporos Sarcopenia 2015;1(1):22-38.
• 14. Fenech M. Vitamins associated with brain aging, mild cognitive impairment, and Alzheimer Disease: biomarkers, epidemiological and experimental evidence, plausible mechanisms, and knowledge gaps. Adv Nutr 2017;8(6):958-970.
• 15. Yavlal F, Güngör HA. Demansta klinik bulgular. Nucl Med Semin 2016;3:134-138.
• 16. Ferland G. Vitamin K and the nervous system: an overview of its action. Adv Nutr 2012;3(2):204-212.
• 17. Carrie I, Portoukalian J, Vicaretti R, Rochford J, Potvin S, Ferland G. Menaquinone-4 concentration is correlated with sphingolipid concentrations in rat brain. J Nutr 2004;134(1):167-172.
• 18. Carrie I, Belanger E, Portoukalian J, Rochford J, Ferland G. Lifelong low-phylloquinone intake is associated with cognitive impairments in old rats. J Nutr 2011;141(8):1495-1501.
• 19. Denisova NA, Booth SL. Vitamin K and sphingolipid metabolism: evidence to date. Nutr Rev 2005;63(4):111-121.
• 20. Ferland G. Vitamin K and brain function. Semin Thromb Hemost 2013;39(8):849-855.
• 21. Li J, Lin JC, Wang H, Peterson JW, Furie BC, Furie B, et al. Novel role of vitamin K in preventing oxidative injury to developing oligodendrocytes and neurons. J Neurosci 2003;23(13):5816-5826.
• 22. Moriya M, Nakatsuji Y, Okuno T, Hamasaki T, Sawada M, Sakoda S. Vitamin K2 ameliorates experimental autoimmune encephalomyelitis in Lewis rats. J Neuroimmunol 2005;170(1-2):11-20.
• 23. Ohsaki Y, Shirakawa H, Miura A, Giriwono PE, Sato S, Ohashi A, et al. Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor κB through the repression of IKKα/β phosphorylation. J Nutr Biochem 2010;21(11):1120-1126.
• 24. Shafit-Zagardo B, Gruber RC, DuBois J. The role of TAM family receptors and ligands in the nervous system: from development to pathobiology. Pharmacol Ther 2018;188:97-117.
• 25. Grommes C, Lee CYD, Wilkinson BL, Jiang Q, Koenigsknecht-Talboo JL, Varnum B, et al. Regulation of microglial phagocytosis and inflammatory gene expression by Gas6 acting on the Axl/Mer family of tyrosine kinases. J Neuroimmune Pharmacol 2008;3(2):130-140.
• 26. Zhu Y, Wang W, Xian N, Wu B. Inhibition of TYRO3/Akt signaling participates in hypoxic injury in hippocampal neurons. Neural Regen Res 2016;11(5):752-757.27. Alzheimer’s Association. 2019 Alzheimer’s disease facts and figures. Alzheimer’s Dement 2019;15(3):321-387.
• 28. Presse N, Belleville S, Gaudreau P, Greenwood CE, Kergoat MJ, Morais JA, et al. Vitamin K status and cognitive function in healthy older adults. Neurobiol Aging 2013;34(12):2777-2783.
• 29. Soutif-Veillon A, Ferland G, Rolland Y, Presse N, Boucher K, Feart C, et al. Increased dietary vitamin K intake is associated with less severe subjective memory complaint among older adults. Maturitas 2016;93:131-136.
• 30. Chouet J, Ferland G, Feart C, Rolland Y, Presse N, Boucher K, et al. Dietary vitamin K intake is associated with cognition and behaviour among geriatric patients: the CLIP study. Nutrients 2015;7:6739-6750.
• 31. Presse N, Shatenstein B, Kergoat MJ, Ferland G. Validation of a semi-quantitative food frequency questionnare measuring dietary vitamin K intake in elderly people. J Am Diet Assoc 2009;109(7):1251-1255.
• 32. Kiely A, Ferland G, Ouliass B, O’Toole PW, Purtill H, O’Connor EM. Vitamin K status and inflammation are associated with cognition in older Irish adults. Nutr Neurosci 2018;19:1-9 (Epub ahead of print), doi: 10.1080/1028415X.2018.1536411.
• 33. Presse N, Shatenstein B, Kergoat MJ, Ferland G. Low vitamin K intakes in community-dwelling elders at an early stage of Alzheimer’s Disease. J Am Diet Assoc 2008;108(12):2095-2099.
• 34. van Den Heuvel EGHM, van Schoor NM, Vermeer C, Zwijsen RML, den Heijer M, Comijs HC. Vitamin K status is not associated with cognitive decline in middle aged adults. J Nutr Health Aging 2015;19(9):908-912.
• 35. Annweiler C, Ferland G, Barberger-Gateau P, Brangier A, Rolland Y, Beauchet O. Vitamin K antagonists and cognitive impairment: results from a cross-sectional pilot study among geriatric patients. J Gerontol A Biol Sci Med Sci 2015;70(1):97-101.
• 36. Nakagawa K, Hirota Y, Sawada N, Yuge N, Watanabe M, Uchino Y, et al. Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme. Nature 2010;468(7320):117-121.
• 37. Tamadon-Nejad S, Ouliass B, Rochford J, Ferland G. Vitamin K deficiency induced by warfarin is associated with cognitive and behavioral perturbations, and alterations in brain sphingolipids in rats. Front Aging Neurosci 2018;10:213. doi: 10.3389/fnagi.2018.00213.
• 38. Ferland G, Feart C, Presse N, Lorrain S, Bazin F, Helmer C, et al. Vitamin K antagonists and cognitive function in older adults: the three-city cohort study. J Gerontol A Biol Sci Med Sci 2016;71(10):1356-1362.
• 39. Brangier A, Ferland G, Rolland Y, Gautier J, Feart C, Annweiler C. Vitamin K antagonists and cognitive decline in older adults: a 24-month follow-up. Nutrients 2018;10:666. doi:10.3390/nu10060666.
• 40. Brangier A, Celle S, Roche F, Beauchet O, Ferland G, Annweiler C. Use of vitamin K antagonists and brain morphological changes in older adults: an exposed/unexposed Voxel-Based Morphometric study. Dement Geriatr Cogn Disord 2018;45:18-26.
• 41. Shen L, Zhang CZ, Gu ZC, Lin HW, Liu XY, Liu XY, et al. Risk of cognitive impairment with non-vitamin K antagonist oral anticoagulants in atrial fibrillation. Protocol for a systemic review of randomized controlled trials and real world studies. Medicine (Baltimore) 2018;97(34):e12072.
• 42. Jacobs V, Graves KG, Bunch TJ. Anticoagulant use in atrial fibrillation and risk of dementia: review of contemporary knowledge. Expert Rev Cardiovasc Ther 2017;15(12):897-903.
• 43. Friberg L, Rosenqvist M. Less dementia with oral anticoagulation in atrial fibrillation. Eur Heart J 2018;39(6):453-460.
• 44. Zhang C, Gu Z-C, Shen L, Pan M_M, Yan Y-D, Pu J, et al. Non-vitamin K antagonist oral anticoagulants and cognitive impairment in atrial fibrillation: insights from the meta-analysis of over 90,000 patients of randomized controlled trials and real-world studies. Front Aging Neurosci 2018;10:258. doi: 10.3389/fnagi.2018.00258.
• 45. Søgaard M, Skøjth F, Jensen M, Kjældgaard JN, Lip GYH, Larsen TB, et al. Nonvitamin K antagonists oral anticoagulants versus warfarin in atrial fibrillation patients and risk of dementia: a nationwide propensity-weighted cohort study. J Am Heart Assoc 2019;8:e011358. doi: 10. 1161/JAHA.118.011358.