PARAOXONASE AND ARYLESTERASE ACTIVITIES IN ADULTS WITH VITAMIN D DEFICIENCY

Yıl 2021, Cilt: 11 Sayı: 3, 571 - 575, 22.09.2021

Filiz Alkan Baylan , Metin Kılınç , Yeliz Doboğlu , Hatice Sağer

https://doi.org/10.31832/smj.913255

Öz

Objective: The aim of this study was to evaluate paraoxonase (PON-1) and arylesterase (ARE) enzyme activity and to evaluate the relationship between vitamin D level and serum lipids and Lipoprotein a (Lp (a)) in adults with vitamin D deficiency.
Materials and Methods: 43 patients with vitamin D deficiency and 37 healthy individuals with similar demographic characteristics were included in the study. A 25 (OH) D below 20 ng / mL was considered a vitamin D deficiency. PON-1, ARE enzyme activities, Lp (a) and serum I,ipid levels were compared between the groups.
Results: PON activity in patients with vitamin D deficiency was found to be lower than healthy control group. ARE activity and Lp (a) were similar between the groups. A positive correlation was observed between vitamin D and PON.
Conclusion: The vitamin D deficient group had lower PON-1 activity. It was thought that the increase in oxidative stress caused by vitamin D deficiency may be caused by the increase in LDL levels and the decrease in HDL levels together with the decrease in PON-1 activity.

Anahtar Kelimeler

Vitamin D, Paroxonase, Arylesterase, Lipoprotein a

D Vitamini Eksikliği Olan Yetişkinlerde Paraoksonaz ve Arilesteraz Aktiviteleri

Öz

Amaç: Bu çalışmanın amacı, D vitamini eksikliği olan erişkinlerde Paroksonaz (PON) ve Arilesteraz (ARE) enzim aktivitelerini araştırmak, D vitamini eksikliğinin oksidatif stres ve kardiyovasküler hastalıklar için risk belirteci olan PON-1, ARE ve Lp (a) üzerindeki etkilerini değerlendirmektir.
Gereç ve Yöntemler: Çalışmaya D vitamini eksikliği olan 43 hasta ve benzer demografik özelliklere sahip olan 37 sağlıklı birey dahil edildi. 25 (OH) D'nin 20 ng/mL' nin altında olması D vitamini eksikliği olarak kabul edildi. Gruplar arasında PON-1, ARE enzim aktiviteleri, Lp (a) ve serum lipid düzeyleri karşılaştırıldı.
Bulgular: D vitamini eksikliği olan hastalarda PON aktivitesi sağlıklı kontrol grubuna göre düşük bulundu. Gruplar arasında ARE aktivitesi ve Lp (a) benzer düzeylerdeydi. D vitamini ile PON arasında pozitif yönde bir ilişki gözlemlendi.
Sonuç: D vitamini eksikliği olan grup daha düşük PON-1 aktivitesine sahipti. D vitamini eksikliğinin neden olduğu oksidatif stres artışına, LDL düzeylerindeki artış ve HDL düzeyindeki azalma ile birlikte PON-1 aktivitesinin düşüklüğünün neden olabileceği düşünüldü.

Anahtar Kelimeler

D vitamini, Paroksonaz, Arilesteraz, Lipoprotein a

Kaynakça

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