Long Term Effects of Mild Severity COVID-19 on Left Ventricular Functions

Yıl 2022, Cilt: 12 Sayı: 3, 422 - 429, 29.09.2022

Osman Bektaş , Ahmet Karagöz , Feyza Nur Topçu Yenerçağ , Seçkin Dereli , Celali Kurt , Yasemin Kaya

https://doi.org/10.31832/smj.1092699

Öz

Objective: We aimed to evaluate long term effects of COVID-19 disease on left ventricular function using speckle tracking echocardiography.
Methods: In our study, 96 non-hospitalized patients who were diagnosed with COVID-19 disease in our center between 15 August 2020 and 01 September 2020 and 96 age and gender matched control subjects were included.
Results:The mean follow up duration was 137 ± 7 days. White blood cell, neutrophile and lymphocyte were significantly lower and C-reactive protein (CRP) and neutrophil to lymphocyte ratio (NLR) were significantly higher in the COVID-19 group. (6.6 ± 2.8 vs. 24.4 ± 21.8, p <0.001 and 4.1 ± 2.5 vs. 7.1 ± 4, p <0.001, respectively). Global longutinal strain (LV-GLS) and global circumferential strain (LV-GCS) were significantly lower in the COVID-19 group. (-20.1 ± 3.1 vs -15.9 ± 2, p <0.001 and -29.3 ± 2.1 vs -26.3 ± 2.1, p <0.001, respectively). LV-GLS and LV-GCS were found to be negatively correlated with CRP (rs = -0.515, p <0.001 and rs = 0.-466, p <0.001, respectively) and NLR (rs = -0.494, p <0.001 and rs = -434, p <0.001, respectively).
Conclusion: Deteriorating effects of COVID-19 disease on both LV-GCS and LV-GLS can be seen even in the long term. These detrimental effects seem to be associated with CRP levels and NLR measured in the course of active infection.

Anahtar Kelimeler

Covid 19, Left ventricular dysfunction, echocardiography

Destekleyen Kurum

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Proje Numarası

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Teşekkür

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Hafif Şiddette COVID-19'un Sol Ventrikül Fonksiyonları Üzerindeki Uzun Dönem Etkileri

Öz

Amaç: COVID-19 hastalığının, sol ventrikül fonksiyonu üzerindeki uzun dönem etkilerini speckle tracking ekokardiyografi kullanarak, değerlendirmeyi amaçladık.
Yöntemler: Çalışmamıza 15 Ağustos 2020 - 01 Eylül 2020 tarihleri arasında merkezimizde COVID-19 hastalığı tanısı konan ve hastaneye yatmayan 96 hasta ile yaş ve cinsiyet olarak uyumlu, 96 kontrol olgusu dahil edildi.
Bulgular: Ortalama takip süresi 137 ± 7 gündü. Beyaz kan hücresi, nötrofil ve lenfosit, COVID-19 grubunda önemli ölçüde daha düşüktü ve C-reaktif protein (CRP) ve nötrofil lenfosit oranı (NLR) önemli ölçüde daha yüksekti. (sırasıyla 6,6 ± 2,8 - 24,4 ± 21,8, p <0,001 ve 4,1 ± 2,5 - 7,1 ± 4, p <0,001). Global longutinal strain (LV-GLS) ve global circumferential strain (LV-GCS), COVID-19 grubunda önemli ölçüde daha düşüktü. (-20,1 ± 3,1 vs -15,9 ± 2, p <0,001 ve -29,3 ± 2,1 vs -26.3 ± 2,1, p <0,001). LV-GLS ve LV-GCS'nin CRP (sırasıyla rs = -0.515, p <0.001 ve rs = 0.-466, p <0.001) ve NLR (rs = -0.494, p <0.001 ve rs = -434, p <0,001, sırasıyla).
Sonuç: COVID-19 hastalığının hem LV-GCS hem de LV-GLS üzerindeki olumsuz etkileri uzun süre devam etmektedir. Bu olumsuz etkiler, aktif enfeksiyon sırasında ölçülen CRP seviyeleri ve NLR ile ilişkili görünmektedir.

Anahtar Kelimeler

Covid 19,, Sol ventrikül disfonksiyonu, Ekokardiyografi

Proje Numarası

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Kaynakça

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