Doğumsal Hipotiroidi ile Ebeveyn Yaşı İlişkisi

Yıl 2019, , 451 - 455, 23.12.2019

Hale Tuhan

https://doi.org/10.12956/tchd.572367

Öz

Amaç: Çalışmamızda, tiroid disgenezisi ile ebeveyn yaşı arasındaki ilişkiyi değerlendirmeyi amaçladık.

Gereç ve Yöntemler: Kliniğimizde yaşları 0-17.9 arasında değişen, tiroid disgenezisi tanısı ile takip edilen 105 hastanın

verileri incelendi. Hastaların ve ebeveynlerinin yaşı, cinsiyeti, anne-baba arasındaki akrabalık durumu, ailede doğumsal

hipotiroidi öyküsü, klinik ve laboratuvar bulguları kaydedildi. Hasta gruplarındaki doğum tarihleri dikkate alınarak ve doğum

tarihleri eşleştirilerek her bir hastaya altı sağlıklı çocuk olacak şekilde kontrol grubu oluşturuldu.

Bulgular: Çalışmaya 105 tiroid disgenezisi tanılı olgu (56 kız, %53.3) ve 630 kontrol dahil edildi. Elli olguda (%47.6)

hipoplazi, 26 olguda (%24.8) ektopi, 20 olguda (%19.0) aplazi, 9 olguda (%8.6) hemiagenezi saptandı. Tiroid disgenezili

olguların anne yaşları ortalaması 27.87 ± 5.36 yıldı, kontrol grubuna göre daha yüksek saptandı (p<0,05). Anne yaş

grupları yüzdeleri karşılaştırıldığında 28-31 yaş grubunda ve 32 ve üzeri yaş grubunda tiroid disgenezili bebek sahibi

olma riski yüksek saptandı (p<0.05).

Sonuç: Çalışmamız, tiroid disgenezisi tanılı olgularda anne yaşının sağlıklı kontrollere göre daha ileri olduğunu göstermiştir

Anahtar Kelimeler

Doğumsal hipotiroidi, Tiroid disgenezisi

The Relation Between Congenital Hypothyroidism and Parental Age

Öz

Objective: In this study, we aimed to evaluate the relationship between thyroid dysgenesis and parental age.

Material and Methods: A total of 105 patients with thyroid dysgenesis who were between 0-17.9 years of age

were studied. The age of the patients and their parents, gender, parental consanguinity, family history of congenital

hypothyroidism, clinical and laboratory findings were recorded. Control group consist of six healthy children for each

patient, considering their birth dates.

Results: A total of 105 patients (56 females, 53.3%) with thyroid dysgenesis and 630 controls were included in the

study. Hypoplasia was detected in 50 cases (46.6%), ectopia in 26 cases (24.8%), aplasia in 20 cases (19.0%) and

hemiagenesis in 9 cases (8.6%). The mean maternal age of the patients with thyroid dysgenesis was 27.87±5.36 years,

which is significantly higher than the control group (p<0.05). There was an increased risk of having a baby with thyroid

dysgenesis in the 28-31 years and > 32 years age groups (p<0.05).

Conclusion: Our study showed that maternal age was higher in the patients with thyroid dysgenesis than in the control

group.

Anahtar Kelimeler

Congenital hypothyroidism, Thyroid dysgenesis

Kaynakça

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