Nonalkolik yağlı karaciğer hastalığı olan bireylerde Tp-e intervali ve Tp-e/qt oranı

Yıl 2019, Cilt: 10 Sayı: 3, 358 - 363, 30.09.2019

Bahar Tekin Tak , Serkan Çay Mahmut Yüksel Firdevs Ayşenur Ekizler , Meral Akdoğan Ayhan Habibe Kafes , Çağrı Yayla , Ertuğrul Kayaçetin

https://doi.org/10.18663/tjcl.555313

Öz

Giriş:
Elektrokardiyografide (EKG) ventriküler repolarizasyon Tp-e
intervali ve kalp hızına göre düzeltilmiş QT (QTc) aralığı
kullanılarak değerlendirilir. Uzamış Tp-e/QTc oranı aritmiler ve
kardiyak mortalite riskinde artışla ilişkilidir. NASH
(nonalkolik steatohepatit)’
in ventriküler repolarizasyon üzerine etkileriyle ilgili az sayıda
çalışma olduğu için, NASH
hastalarında Tp-e
interval ölçümlerini ve Tp-e/QT oranını değerlendirmeyi
amaçladık.

Gereç
ve Yöntemler:
Çalışmamıza toplam
97 NASH
hastası ile 77 kişilik kontrol grubu dahil edildi. Tp-e intervali,
Tp-e/QT ve Tp-e/QTc oranları 12-lead elektrokardiyogram ile
ölçüldü.

Bulgular:
Kalp hızı her iki grupta da benzerdi (74.8
± 10.1 vs.
75.7
± 11.7;
p=0.598). QT interval (396.0
± 34.2 vs.
384.6
± 30.7;
p=0.023) ve QTc interval (403.6
± 34.8 vs.
399.9
± 36.3;
p=0.027), Tp-e interval (100.4
± 13.6 vs.
91.4
± 13.4;
p<0.001) , Tp-e/QT oranı (0.25
± 0.03 vs.
0.23
± 0.03;
p=0.003) ve Tp-e/QTc oranı (0.23
± 0.03 vs.
0.21
± 0.03;
p=0.002), gruplararası anlamlı olarak farklı saptandı. Tp-e
interval (r= 0.328, p<0.001) ve Tp-e/QTc oranı ile hepatik
steatoz derecesi (r=
0.237, p=0.002) arasında anlamlı bir ilişki mevcuttu.

Sonuç:
NASH

hastalarında Tp-e
interval, QT
interval, QTc interval,
Tp-e/QT ve Tp-e/QTc
oranları uzamıştı.
NASH
‘in artmış Tp-e/QT oranı için bağımsız bir faktör olduğu
bulundu. Bu çalışma NASH
hastalarında Tp-e
intervali ve Tp-e/QT parametrelerinin araştırıldığı ilk
çalışmadır.

Anahtar Kelimeler

Tp-e intervali, Tp-e/QTc oranı, ventirküler repolarizasyon, NASH

Tp-e interval and Tp-e/qt ratio in patients with non alcoholic fatty liver disease

Öz

Aim:   Ventricular repolarization is assessed using
the Tp-e interval and QT interval corrected by the heart rate (QTc) via an
electrocardiogram (ECG). Prolonged Tp-e/QTc is related with an increased risk
of arrhythmias and cardiac mortality. As there have been few reports regarding
the effects of NAFLD on ventricular repolarization, we aimed
to appraise the assessment of Tp-e
interval and Tp-e/QT ratio in patients with NAFLD.

 

Material
and Methods: Totally 97 patients with NAFLD and 77 control subjects were enrolled in our study. Tp-e interval, Tp-e/QT and Tp-e/QTc
ratios were measured from the 12-lead electrocardiogram.

 

Results:
Heart rate was similar between groups (74.8 ± 10.1 vs. 75.7 ± 11.7; p=0.598). QT interval
(396.0 ± 34.2 vs.
384.6 ± 30.7;
p=0.023) and QTc interval  (403.6 ± 34.8 vs. 399.9 ± 36.3; p=0.027), Tp-e
interval (100.4 ± 13.6 vs.
91.4 ± 13.4;
p<0.001) , Tp-e/QT ratio (0.25
± 0.03 vs.
0.23 ± 0.03;
p=0.003) and Tp-e/QTc ratio (0.23
± 0.03 vs.
0.21 ± 0.03;
p=0.002) were significantly different between groups. There was significant
correlation between Tp-e interval  (r=
0.328, p<0.001) and Tp-e/QTc ratio and hepatic steatosis grade (r= 0.237,
p=0.002).

Conclusion:
Tp-e interval, QT
interval, QTc interval, Tp-e/QT and Tp-e/QTc ratios were prolonged in patients
with NAFLD.
NAFLD
is found an independent factor for increased Tp-e/QT ratio. This is the first study that investigated the Tp-e
interval  and Tp-e/QT parameters in patients with NAFLD.

Anahtar Kelimeler

NAFLD, Tp-e interval, Tp-e/QTc ratio, ventricular repolarization

Kaynakça

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