The predictive value of triglyceride to HDL ratio in determining coronary artery disease and plaque morphology

Yıl 2019, Cilt: 10 Sayı: 4, 467 - 473, 31.12.2019

Elif Hande Özcan Çetin , Mehmet Serkan Cetin , Hasan Can Könte Nezaket Merve Yaman Bahar Tekın Tak , Firdevs Aysenur Ekizler , Özcan Özeke , Serkan Topaloglu Dursun Aras

https://doi.org/10.18663/tjcl.551119

Cited By: 2

Öz

Aim: As
a new atherogenic index, the association of triglyceride to HDL ratio (TG /
HDL)with insulin resistance and its significance in risk and prognostic
evaluation of cardiovascular diseases have been shown in several studies. TG /
HDL ratio may be useful in predicting the presence of coronary artery disease
in the population with lowcardiovascular disease risk. In this study, we aimed
to evaluate the efficacy of TG / HDL ratio in predicting the presence of CAD
and its relationship with plaque morphology, increased coronary calcium score and
the degree of stenosisin patients who underwent computed tomographic coronary
angiography (CTCA).

Material and Methods:
This retrospective cross-sectional study included 161 consecutive patients with
low cardiovascular disease risk who were referred to CTCA between 2014-2018.

Results:CAD
was detected in 90 patients (55.9%). The TG / HDL ratio was higher in patients
with CAD (2.9 (1.7-4.7) vs. 2.6 (1.6-4.1), p = 0.05). In logistic regression
analysis, with age, in each one unit increase in TG / HDL ratio was found to
associated with 28.7% increase in probabilty of CAD. TG / HDL ratio was not
found to be statistically significant in predicting the presence of soft
plaques and severe stenosis.

Conclusıon:With advancing age,TG / HDL ratiowas found to be an effective
cardiometabolic marker as a more effective parameter than the metabolic
syndrome in predicting the presence of CAD. By providing a quantitative
assessment with this readily available ratio of dyslipidemia, a more accurate
risk assessment can be achieved and thus more individualized treatment can be
provided.

Anahtar Kelimeler

Triglyceride to HDL ratio; Coronary Artery Disease; Coronary Calcium Score; Computed tomographic coronary angiography

Trigliserit/HDL oranının, koroner arter hastalığı varlığını ve plak morfolojisini öngördürmedeki yeri

Öz

Amaç:
Yeni bir aterojenik indeks olarak, trigliserid HDL oranının (TG/HDL), insülin
rezistansı ile ilişkisi ve kardiyovasküler hastalıklarda risk ve prognostik
değerlendirmedeki önemi çeşitli çalışmalarda gösterilmiştir. TG/HDL oranı,
düşük kardiyovasküler hastalık riskine sahip populasyonda koroner arter hastalığı
varlığını öngördürmede faydalı olabilir. Bu çalışmamızda TG/HDL oranının
bilgisayarlı tomografik koroner anjiyografi (BTKA) planlanan hastalarda KAH
varlığını öngördürmedeki etkinliği ve bu oranın plak morfolojisi, artmış
koroner kalsiyum skoru ve stenoz derecesi ile ilişkisini değerlendirmeyi
amaçladık.

Gereç ve Yöntemler:
Bu retrospektif kesitsel çalışmaya düşük kardiyovasküler riski olup, 2014-2018
tarihleri arasında BTKA’ya refere edilen ardışık 161 hasta dahil edildi.

Bulgular: 90
hastada (%55.9) KAH saptandı. TG/HDL oranı KAH olan hastalarda yüksekti (2.9
(1.7-4.7)’e karşı 2.6 (1.6-4.1), p=0.05). Lojistik regresyon analizinde, yaş
ile birlikte, TG/HDL oranında her bir birim artış,KAH ihtimalinde%28.7 artış
ile ilişkili saptandı. Yumuşak plak varlığını ve ciddi darlığı öngördürmede
TG/HDL oranı istatistiksel olarak anlamlı bir parametre olarak saptanmadı.

Sonuç: İlerleyen yaşın yanında, TG/HDL oranı KAH varlığını öngördürmede
metabolik sendrom varlığından daha etkin bir parametre olarak saptanmış ve
etkin bir kardiyometabolik belirteç olduğu gösterilmiştir. Bu kolaylıkla elde
edilebilen dislipidemi oranı ile niceliksel değerlendirme sağlanarak daha doğru
risk değerlendirilmesi ve böylelikle daha bireyselleştirilmiş tedavi
sağlanabilir.

Anahtar Kelimeler

Trigliserid HDL oranı; Koroner Arter Hastalığı; Koroner Kalsiyum Skoru; Bilgisayarlı Tomografik Koroner Anjiyografi

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