Old complication, new marker: the relationship between the systemic immune-inflammation index and post-pericardiotomy syndrome.

Yıl 2023, Cilt: 6 Sayı: 1, 16 - 22, 28.03.2023

Sercan Çayırlı , Berk Mutlu , Ömer Faruk Rahman , Sevil Gülaştı , Selim Durmaz , Hasan Güngör

https://doi.org/10.56150/tjhsl.1210567

Öz

Background: Post-pericardiotomy syndrome (PPS) is a common complication after cardiovascular surgery. Post-operative hospitalizations are prolonged due to PPS and mortality is increased due to pericardial effusion leading to cardiac tamponade. Studies have shown that inflammation plays a role in etiology.
Objectives: The systemic immune-inflammation index (SII) is a new non-invasive marker that has been shown to be effective in predicting inflammatory diseases. In our study, we aimed to investigate the association between the development of PPS and SII in patients undergoing open-heart surgery
Methods: Patients who underwent elective open-heart surgery at our institution between 2017 and 2022 were retrospectively studied. Patients who developed PPS and patients who did not develop PPS were included as two different groups in the study. We investigated whether there was a significant difference between the two groups in terms of SII.
Results: A total of 228 patients were enrolled in the study, 132 in the patient group and 96 in the control group. The mean age was 63.48 years in the patient group and 65.09 years in the control group and no statistically significant difference was found (p 0.34). There were also no significant differences between the two groups in terms of gender (p 0.47), hypertension (p 0.22), hyperlipidemia (p 0.66), coronary artery disease (p 0.76), diabetes (p 0.023), smoking (p 0.35), and chronic obstructive pulmonary disease (p 0.49). The median value for SII was 568.91 (530.17) in the patient group and 634.79 (613.23) in the control group, and no significant difference was found between the groups (p 0.208). Statistically significant differences were found in hemoglobin (p 0.03), hematocrit (p 0.02), and glucose (p 0.018) values between both groups.
Conclusion: The SII is not a useful parameter for predicting post-pericardiotomy syndrome. Comprehensive studies with larger patient populations including subgroup analyzes are needed in this regard.

Anahtar Kelimeler

post pericardiotomi syndrome, inflammation, bypass

Proje Numarası

yok

Kaynakça

• 1) İmazio M, Brucato A, Ferrazzi P, et al. Colchicine For Prevention Of Postpericardiotomy Syndrome And Postoperative Atrial Fibrillation. The COPPS-2 Randomized Clinical Trial. J Am Med Assoc. 2014; 312(10):1016-3.
• 2) Imazio M. The Post-Pericardiotomy Syndrome. Curr Opin Pulm Med. 2012;18:366–4.
• 3) Fu H, Zheng J, Cai J, Zeng K, Yao J, Chen L. et al. Systemic İmmune-İnflammation İndex (SII) İs Useful To Predict Survival Outcomes İn Patients After Liver Transplantation For Hepatocellular Carcinoma Within Hangzhou Criteria. Cellphysiol Biochem 2018;47:293-01.
• 4) Hu B, Yang XR, Xu Y, Sun YF, Sun C, Guo W, et al. Systemic İmmune-İnflammation İndex Predicts Prognosis Of Patients After Curative Resection For Hepatocellular Carcinoma. Clin Cancer Res. 2014;20:6212-22.
• 5) Agus, Hicaz Z.K, Arslan S, Yildirim Ç, Erturk C, Kalkan M., Kalkan A. Yildiz, M. Systemic İmmune-İnflammation İndex Predicts Mortality İn İnfective Endocarditis. Journal Of The Saudi Heart Association. 2020;32:57-64.
• 6) Candemir M, Kiziltunç E, Nurkoç S, Şahinarslan A. Relationship Between Systemic Immune-Inflammation Index (SII) And The Severity Of Stable Coronary Artery Disease. Angiology. 2021;72:575-1.
• 7) Imazio M, Hoit BD. Post-Cardiac İnjury Syndromes: An Emerging Cause Of Pericardial Diseases. Int J Cardiol. 2013;168: 648-2
• 8) Lehto J, Kiviniemi TO, Gunn J, et al. Occurrence of postpericardiotomy syndrome admissions: A population-based registry study. Ann Med. 2016;48(1-2): 28–33.
• 9) Gubbels Bupp MR. Sex, the aging immune system, and chronic disease. Cell Immunol. 2015;294(2): 102–110.
• 10) Lehto J, Kiviniemi T, Gunn J, et al. Occurrence of postpericardiotomy syndrome: association with operation type and postoperative mortality after openheart operations. J Am Heart Assoc. 2018;7(22): e010269.
• 11) Selcuk M, Cınar T., Saylık F, Dogan S., Selcuk İ., Orhan A.H. Predictive Value Of Systemic Immune Inflammation Index For Postoperative Atrial Fibrillation İn Patients Undergoing Isolated Coronary Artery Bypass Grafting. Medeni Med J 2021;36:318-4.
• 12) Gaofan S, Ying Z., Xiao R., Tingting Z., Gong B. Systemic İmmune İnflammation İndex As A Promising Predictor Of Mortality İn Patients With Acute Coronary Syndrome: A Real-World Study. Journal Of International Medical Research. 2021;49(5) 1–9.
• 13) Hu Zd, Sun Y, Guo J, Huang Yl, Qın Bd, Gao Q, Qın Q, Deng Am, Zhong Rq. Red Blood Cell Distribution Width And Neutrophil/Lymphocyte Ratio Are Positively Correlated With Disease Activity İn Primary Sjogren's Syndrome. Clin Biochem 2014; 47: 287-90.
• 14) Fu H, Qın B, Hu Z, Ma N, Yang M, Weı T, Tang Q, Huang Y, Huang F, Lıang Y, Yang Z, Zhong R. Neutrophil- And Platelet-To-Lymphocyte Ratios Are Correlated With Disease Activity İn Rheumatoid Arthritis. Clin Lab 2015; 61: 269-73
• 15) Rıfatoglu En, En B.B, Ekız O, Dogramacı Ac. Neutrophil To Lymphocyte Ratio İn Behçet’s Disease As A Marker Of Disease Activity. Acta Dermatoven APA 2014; 23: 65-7.
• 16) Ertürk M., Surgit Ö., Yalcın A.A., Uzun F., Akgül Ö., Gürdoğan M., et al. Nötrofil/Lenfosit oranı ile yavaş koroner akım arasındaki ilişkinin incelenmesi. Diclemedj. 2013; 40 (4): 537-2
• 17) Sevuk U., Bılgıc A., Altındag R., Baysal E., Yaylak B., Adıyaman M.S. et al. Value Of The Neutrophil-To-Lymphocyte Ratio İn Predicting Post-Pericardiotomy Syndrome After Cardiac Surgery. European Review For Medical And Pharmacological Sciences. 2016; 20: 906-11.
• 18) Turkmen K, Erdur FM, Ozcicek F, Et Al: Platelet-To-Lymphocyte Ratio Better Predicts İnflammation Than Neutrophil-To-Lymphocyte Ratio İn End-Stage Renal Disease Patients. Hemodial Int 2013;17:391–6.
• 19) Gungor H, Babu A.S, Zencir C., Akpek M., Selvi M., Erkan M.H. et al. Association Of Preoperative Platelet-To-Lymphocyte Ratio With Atrial Fibrillation After Coronary Artery Bypass Graft Surgery. Med Princ Pract 2017;26:164–8.
• 20) Atak B., Aktas G., Duman T.T., Erkus E., Kocak M.Z., Savli H. Diabetes Control Could Through Platelet-To-Lymphocyte Ratio İn Hemograms. Rev Assoc Med Bras 2019; 65(1):38-2.
• 21) Lehto J, Gunn J, Karjalainen P, et al. Incidence And Risk Factors Of Postpericardiotomy Syndrome Requiring Medical Attention: The Finland Postpericardiotomy Syndrome Study. J Thorac Cardiovasc Surg. 2015;149(5):1324–9.
• 22) Oktay AA, Akturk HK, Esenboga K, Javed F, et al. Pathophysiology And Prevention Of Heart Disease İn Diabetes Mellitus. Curr Probl Cardiol. 2018;43(3): 68–110